Direct Differentiation of Human Pluripotent Stem Cells into Haploid Spermatogenic Cells

Autor: Charles A. Easley, IV, Bart T. Phillips, Megan M. McGuire, Jennifer M. Barringer, Hanna Valli, Brian P. Hermann, Calvin R. Simerly, Aleksander Rajkovic, Toshio Miki, Kyle E. Orwig, Gerald P. Schatten

Publikováno v: Cell Reports, Vol 2, Iss 3, Pp 440-446 (2012)

Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have been shown to differentiate into primordial germ cells (PGCs) but not into spermatogonia, haploid spermatocytes, or spermatids. Here, we show that hESCs and hiPSCs di

Externí odkaz: https://doaj.org/article/1beb09709e354fb38909b259e22a05e0

Granulocyte colony-stimulating factor with or without stem cell factor extends time to premature ovarian insufficiency in female mice treated with alkylating chemotherapy

Autor: Tianjiao Chu, Julia Donohue, Megan M. McGuire, Kyle E. Orwig, Meena Sukhwani, Malgorzata E. Skaznik-Wikiel, Aleksandar Rajkovic, Thomas C. Krivak

Publikováno v: Fertility and sterility, vol 99, iss 7

Objective To examine gonadal protective properties of granulocyte colony-stimulating factor (G-CSF) alone or in combination with stem cell factor (SCF) in female mice treated with high-dose alkylating chemotherapy. Design Experimental laboratory anim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60471f00534c992ba6bdee1eb97e9ff0
https://pubmed.ncbi.nlm.nih.gov/23453120

Genomic analysis using high-resolution single-nucleotide polymorphism arrays reveals novel microdeletions associated with premature ovarian failure

Autor: Natalie J. Engel, Ertug Kovanci, Megan M. McGuire, Aleksandar Rajkovic, Wayne Bowden, Hyo Won Ahn

Publikováno v: Fertility and sterility. 95(5)

Objective To analyze DNA from women with premature ovarian failure (POF) for genome-wide copy-number variations (CNVs), focusing on novel autosomal microdeletions. Design Case-control genetic association study. Setting Department of Obstetrics and Gy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f010b69060b89e7042655a7341cb256a
https://pubmed.ncbi.nlm.nih.gov/21256485

Global VAX: A U.S. contribution to global COVID-19 vaccination efforts, 2021-2023.

Autor: Dahl BA; Centers for Disease Control and Prevention, United States. Electronic address: bid5@cdc.gov., Tritter B; US Agency for International Development, United States., Butryn D; Centers for Disease Control and Prevention, United States., Dahlke M; Centers for Disease Control and Prevention, United States., Browning S; Centers for Disease Control and Prevention, United States., Gelting R; Centers for Disease Control and Prevention, United States., Fleming M; Centers for Disease Control and Prevention, United States., Ortiz N; Centers for Disease Control and Prevention, United States., Labrador J; Centers for Disease Control and Prevention, United States., Novak R; Centers for Disease Control and Prevention, United States., Fitter D; Centers for Disease Control and Prevention, United States., Bell E; Centers for Disease Control and Prevention, United States., McGuire M; US Agency for International Development, United States., Rosenbaum R; US Agency for International Development, United States., Pulwer R; US Agency for International Development, United States., Wun J; US Agency for International Development, United States., McCaffrey A; US Agency for International Development, United States., Chowdhury M; US Agency for International Development, United States., Parks N; US Agency for International Development, United States., Cunningham M; US Agency for International Development, United States., Mounts A; Taskforce for Global Health, United States., Curry D; Taskforce for Global Health, United States., Richardson D; Taskforce for Global Health, United States., Grant G; Centers for Disease Control and Prevention, United States.

Publikováno v: Vaccine [Vaccine] 2024 Mar 23. Date of Electronic Publication: 2024 Mar 23.

Compositional Characterization of Different Industrial White and Red Grape Pomaces in Virginia and the Potential Valorization of the Major Components.

Autor: Jin Q; Department of Food Science and Technology, Virginia Polytechnic Institute and State University, 1230 Washington St. SW, Blacksburg, VA 24061, USA., O'Hair J; Department of Food Science and Technology, Virginia Polytechnic Institute and State University, 1230 Washington St. SW, Blacksburg, VA 24061, USA., Stewart AC; Department of Food Science and Technology, Virginia Polytechnic Institute and State University, 1230 Washington St. SW, Blacksburg, VA 24061, USA., O'Keefe SF; Department of Food Science and Technology, Virginia Polytechnic Institute and State University, 1230 Washington St. SW, Blacksburg, VA 24061, USA., Neilson AP; Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, 600 Laureate Way, Kannapolis, NC 28081, USA., Kim YT; Department of Sustainable Biomaterials, Virginia Polytechnic Institute and State University, 230 Cheatham Hall, Blacksburg, VA 24061, USA., McGuire M; White Hall Vineyards, 5282 Sugar Ridge Road, Crozet, VA 22932, USA., Lee A; Department of Food Science and Technology, Virginia Polytechnic Institute and State University, 1230 Washington St. SW, Blacksburg, VA 24061, USA., Wilder G; Department of Food Science and Technology, Virginia Polytechnic Institute and State University, 1230 Washington St. SW, Blacksburg, VA 24061, USA., Huang H; Department of Food Science and Technology, Virginia Polytechnic Institute and State University, 1230 Washington St. SW, Blacksburg, VA 24061, USA.

Publikováno v: Foods (Basel, Switzerland) [Foods] 2019 Dec 11; Vol. 8 (12). Date of Electronic Publication: 2019 Dec 11.