Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Megan M Dacek"'
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Chimeric antigen receptor (CAR) – and T-cell receptor (TCR) – modified T-cells are rapidly emerging as a viable treatment option for cancer patients. While initial clinical trials for these CAR T cells showed response rates of over 90% in some ca
Externí odkaz:
https://doaj.org/article/312ffd5202004fc391742e1e46e4a7d2
Autor:
Martin G. Klatt, Tao Dao, Zhiyuan Yang, Jianying Liu, Sung Soo Mun, Megan M. Dacek, Hanzhi Luo, Thomas J. Gardner, Christopher Bourne, Leila Peraro, Zita E. H. Aretz, Tanya Korontsvit, Michael Lau, Michael G. Kharas, Cheng Liu, David A. Scheinberg
Publikováno v:
Blood. 140:861-874
Target identification for chimeric antigen receptor (CAR) T-cell therapies remains challenging due to the limited repertoire of tumor-specific surface proteins. Intracellular proteins presented in the context of cell surface HLA provide a wide pool o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3643e8df51cc323d81b1f4cba7e8ed
https://doi.org/10.1182/blood.2021012882
https://doi.org/10.1182/blood.2021012882
Autor:
David A. Scheinberg, Tatyana Korontsvit, Aaron Y. Chang, Sung Soo Mun, Elliott J. Brea, Megan M. Dacek, Tao Dao, Christopher Bourne, Martin G. Klatt, Claire Y. Oh
Supplemental Figures and Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41417dae319a4ff322ea94c0b4e688ea
https://doi.org/10.1158/2326-6066.22542430
https://doi.org/10.1158/2326-6066.22542430
Autor:
Jason S. Lewis, Michael J. Evans, Ian L. Fox, Jonathan D. Caen, Thomas R. Dilling, Megan M. Dacek, Kelly E. Henry
Supplementary Data file with additional experimental and figures. SUPPLEMENTAL FIGURE 1: Radiolabeling of [89Zr]Zr-transferrin as shown by instant thin layer chromatography. Radiochemical yield ranged from 60-70% and all radiochemical purity was >99%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535ab87705c4fa629a931cb7739139f9
https://doi.org/10.1158/1078-0432.22476051.v1
https://doi.org/10.1158/1078-0432.22476051.v1
Autor:
Megan M Dacek, Keifer Kurtz, Patrick Wallisch, Stephanie A Pierre, Shireen Shiraz Khayat, Christopher M Bourne, Thomas J Gardner, Kristen C Vogt, Nica Aquino, Anas Younes, David A Scheinberg
Publikováno v:
Blood.
Chimeric antigen receptor (CAR) T cell therapy has shown success in the treatment of hematopoietic malignancies; however, relapse remains a significant issue. To overcome this, we engineered "Orexi" CAR T cells to locally secrete a high affinity CD47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db9515d957c8f35be4739ce7247c9d0e
https://doi.org/10.1182/blood.2022016101
https://doi.org/10.1182/blood.2022016101
Autor:
Megan M. Dacek, Sung Soo Mun, Martin G. Klatt, Tao Dao, Elliott J. Brea, Tatyana Korontsvit, Aaron Y Chang, Christopher M. Bourne, Claire Y. Oh, David A. Scheinberg
Publikováno v:
Cancer Immunol Res
T-cell immunotherapies are often thwarted by the limited presentation of tumor-specific antigens abetted by the downregulation of human leukocyte antigen (HLA). We showed that drugs inhibiting ALK and RET produced dose-related increases in cell-surfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0105f3b403ccb296db243d8656f41a
https://doi.org/10.1158/2326-6066.cir-19-0056
https://doi.org/10.1158/2326-6066.cir-19-0056
Autor:
Thomas J. Gardner, J. Peter Lee, Christopher M. Bourne, Dinali Wijewarnasuriya, Nihar Kinarivala, Keifer G. Kurtz, Broderick C. Corless, Megan M. Dacek, Aaron Y. Chang, George Mo, Kha M. Nguyen, Renier J. Brentjens, Derek S. Tan, David A. Scheinberg
Publikováno v:
Nat Chem Biol
Chimeric Antigen Receptor (CAR)-T cells represent a major breakthrough in cancer therapy, wherein a patient’s own T cells are engineered to recognize a tumor antigen, resulting in activation of a local cytotoxic immune response. However, CAR-T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fffdaf19be59b3d07f97fbb8d3caee33
https://europepmc.org/articles/PMC9152922/
https://europepmc.org/articles/PMC9152922/
Autor:
Michael R. McDevitt, Sarah M. Cheal, Brian H. Santich, Blesida Punzalan, Darren R. Veach, Simone Krebs, Guangbin Yang, Sebastien Monette, Thomas Z. Kubik, Lukas M. Carter, Steven M. Larson, Megan M. Dacek, Daniela Burnes Vargas, Nai-Kong V. Cheung, Ouathek Ouerfelli, David A. Scheinberg, Adam Kesner
Publikováno v:
Bioconjug Chem
Pretargeted imaging and radioimmunotherapy approaches are designed to have superior targeting properties over directly targeted antibodies but impose more complex pharmacology, which hinders efforts to optimize the ligands prior to human applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e68f95bb3d92d08ff564ad00865b4d
https://pubmed.ncbi.nlm.nih.gov/33819023
https://pubmed.ncbi.nlm.nih.gov/33819023
Autor:
Tanya Korontsvit, Michael G. Kharas, Martin G. Klatt, Megan M. Dacek, David A. Scheinberg, Hanzhi Luo, Zita E.H. Aretz, Christopher M. Bourne, Tao Dao, Thomas J. Gardner, Cheng Liu, Leila Peraro, Zhiyuan Yang, Sung Soo Mun, Jianying Liu
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:S447-S448
Context Target identification for CAR-T cell therapies, especially shared targets among different malignancies, remains challenging due to the limited repertoire of tumor-specific surface proteins. Intracellular proteins presented in the context of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e69b8f2f6959f30378658aa700f9378
https://doi.org/10.1016/s2152-2650(21)01994-7
https://doi.org/10.1016/s2152-2650(21)01994-7
Autor:
Christopher M. Bourne, Leila Peraro, David A. Scheinberg, Megan M. Dacek, Kristen C Vogt, Thomas J. Gardner, Pedro C. Silberman, Manish Malviya, Mildred J Unti, Keifer Kurtz, Renier Brentjens
Publikováno v:
Cancers, Vol 12, Iss 2175, p 2175 (2020)
Cancers
Cancers
The recent emergence of engineered cellular therapies, such as Chimeric antigen receptor (CAR) CAR T and T cell receptor (TCR) engineered T cells, has shown great promise in the treatment of various cancers. These agents aggregate and expand exponent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0de704287f077ce67dc35611460c5f9
https://www.mdpi.com/2072-6694/12/8/2175
https://www.mdpi.com/2072-6694/12/8/2175