Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Megan Lo"'
Autor:
Hayarpi Torosyan, Michael D. Paul, Antoine Forget, Megan Lo, Devan Diwanji, Krzysztof Pawłowski, Nevan J. Krogan, Natalia Jura, Kliment A. Verba
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract PEAK pseudokinases are molecular scaffolds which dimerize to regulate cell migration, morphology, and proliferation, as well as cancer progression. The mechanistic role dimerization plays in PEAK scaffolding remains unclear, as there are no
Externí odkaz:
https://doaj.org/article/85045834d2964cfea366be106c88604c
Autor:
Megan Lo, Amnon Sharir, Michael D. Paul, Hayarpi Torosyan, Christopher Agnew, Amy Li, Cynthia Neben, Pauline Marangoni, Libin Xu, David R. Raleigh, Natalia Jura, Ophir D. Klein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Although lipids are known to affect Hedgehog (Hh) signalling, the underlying mechanisms remain unclear. Here, the authors show that Canopy4 regulates membrane sterol lipid levels, with knockout mouse embryos exhibiting digit number changes and other
Externí odkaz:
https://doaj.org/article/b8f457610c994aaaac3b168715601a9d
Publikováno v:
Cells, Vol 11, Iss 9, p 1580 (2022)
The proteasome is a large protein complex responsible for proteolysis in cells. Though the proteasome is widely conserved in all eukaryotes, vertebrates additionally possess tissue-specific proteasomes, termed immunoproteasomes and thymoproteasomes.
Externí odkaz:
https://doaj.org/article/cd96bab9bd0f40c6b3bbd3796444eef7
Autor:
Sogol S Javadi, Kushagra Mathur, Susanna Concha-Garcia, Hursch Patel, Kelly E Perry, Megan Lo, Jeff Taylor, Andy Kaytes, Susan Little, Sara Gianella, Davey Smith, Karine Dubé
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0250882 (2021)
As end-of-life (EOL) HIV cure-related research expands, understanding perspectives of participants' next-of-kin (NOK) is critical to maintaining ethical study conduct. We conducted two small focus groups and two one-on-one interviews using focus grou
Externí odkaz:
https://doaj.org/article/66aac9ec4042441dbe5d673305723409
Autor:
Karine Dubé, Kelly E. Perry, Kushagra Mathur, Megan Lo, Sogol S. Javadi, Hursch Patel, Susanna Concha-Garcia, Jeff Taylor, Andy Kaytes, Lynda Dee, Danielle Campbell, John Kanazawa, David Smith, Sara Gianella, Judith D. Auerbach, Parya Saberi, John A. Sauceda
Publikováno v:
Journal of Virus Eradication, Vol 6, Iss 4, Pp 100008- (2020)
Introduction: The question of what motivates people to participate in research is particularly salient in the HIV field. While participation in HIV research was driven by survival in the 1980’s and early 1990’s, access to novel therapies became t
Externí odkaz:
https://doaj.org/article/10c10163618e4a5ab422f4c1c56d1cd7
Autor:
Rupesh Raina, Vinod Krishnappa, Cheryl Sanchez-Kazi, Alejandro Quiroga, Katherine E. Twombley, Robert Mathias, Megan Lo, Ronith Chakraborty, Shefali Mahesh, Julia Steinke, Timothy Bunchman, Joshua Zaritsky
Publikováno v:
Frontiers in Pediatrics, Vol 7 (2019)
Background: Focal segmental glomerulosclerosis (FSGS) causes end stage renal disease (ESRD) in significant proportion of patients worldwide. Primary FSGS carries poor prognosis and management of FSGS patients, refractory to standard treatments or res
Externí odkaz:
https://doaj.org/article/3fccaae5be214df795598cb64052d3df
Autor:
Cristin D. W. Kaspar, Keia Sanderson, Seza Ozen, Priya S. Verghese, Megan Lo, Timothy E. Bunchman, Scott E. Wenderfer, Jason Kidd
Publikováno v:
International Journal of Nephrology, Vol 2018 (2018)
Objective. To assess practice pattern similarities and differences amongst pediatric rheumatologists and nephrologists in the management of pediatric Granulomatosis with Polyangiitis (GPA). Methods. A voluntary survey was distributed to the Midwest P
Externí odkaz:
https://doaj.org/article/fcca2b617ac3430bbb1482c410243c01
Effects of omega-3 supplementation on markers of autophagy, apoptosis and mitochondrial area density
Publikováno v:
Physiology. 38
In humans, disuse is known to result in muscle atrophy and metabolic dysfunction, including reduced mitochondrial content. Previous data from this cohort found that omega-3 polyunsaturated fatty acid (n-3) supplementation attenuated declines in muscl
Publikováno v:
Currents in Pharmacy Teaching and Learning. 14:425-431
Problematic smartphone use has been associated with numerous factors of mental health including depression, stress, and anxiety. Most of the research in this area has focused on the effects to the smartphone user. One relatively new phenomenon in thi
Autor:
Gabriela Arantes Wagner, Martin Hoenigl, Gary M. Vilke, Kushagra Mathur, Susan J. Little, Christopher J. Coyne, Megan Lo, Lucy E Horton, Jill Blumenthal, Thomas C S Martin
Publikováno v:
AIDS Care. 35:714-718
The objective of this study was to determine hospital costs and revenue of universal opt-out HIV ED screening. An electronic medical record (EMR)-directed, automated ED screening program was instituted at an academic medical center in San Diego, Cali