Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Megan Leander"'
Publikováno v:
eLife, Vol 11 (2022)
A fundamental question in protein science is where allosteric hotspots – residues critical for allosteric signaling – are located, and what properties differentiate them. We carried out deep mutational scanning (DMS) of four homologous bacterial
Externí odkaz:
https://doaj.org/article/bb5c1278379443f2a4bf5d1f04daec34
Publikováno v:
eLife, Vol 10 (2021)
The interaction between a bacteriophage and its host is mediated by the phage's receptor binding protein (RBP). Despite its fundamental role in governing phage activity and host range, molecular rules of RBP function remain a mystery. Here, we system
Externí odkaz:
https://doaj.org/article/5883dcf2873c423a97d212c511324197
Autor:
Megan Leander, Chloe Bass, Kathryn Marchetti, Benjamin F Maynard, Juan Pedro Wulff, Sheila Ons, Ruthann Nichols
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120492 (2015)
Peptidergic signaling regulates cardiac contractility; thus, identifying molecular switches, ligand-receptor contacts, and antagonists aids in exploring the underlying mechanisms to influence health. Myosuppressin (MS), a decapeptide, diminishes card
Externí odkaz:
https://doaj.org/article/842acd85eef845db912f88074f5d4141
Autor:
Benjamin F Maynard, Chloe Bass, Chris Katanski, Kiran Thakur, Beth Manoogian, Megan Leander, Ruthann Nichols
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75502 (2013)
FMRF-NH2 peptides which contain a conserved, identical C-terminal tetrapeptide but unique N terminus modulate cardiac contractility; yet, little is known about the mechanisms involved in signaling. Here, the structure-activity relationships (SARs) of
Externí odkaz:
https://doaj.org/article/97c4c4c2ef2e46d39574e9bf87651bbc
Publikováno v:
eLife. 11
A fundamental question in protein science is where allosteric hotspots – residues critical for allosteric signaling – are located, and what properties differentiate them. We carried out deep mutational scanning (DMS) of four homologous bacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa93164610c726ce773a6b9aa2ab1f7
https://pubmed.ncbi.nlm.nih.gov/36226916
https://pubmed.ncbi.nlm.nih.gov/36226916
Autor:
Karthik Pittala, Ruthann Nichols, Benjamin Maynard, Megan Leander, Jeff Creech, Andre Monteria Rocha, Todd Heron
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1274d6cf344f6f1c7522a844699d3a3
https://doi.org/10.1096/fasebj.2022.36.s1.r2920
https://doi.org/10.1096/fasebj.2022.36.s1.r2920
Publikováno v:
Proc Natl Acad Sci U S A
Allostery is a fundamental regulatory mechanism of protein function. Despite notable advances, understanding the molecular determinants of allostery remains an elusive goal. Our current knowledge of allostery is principally shaped by a structure-cent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e57ed7367dad0bfae2241aae429984e
https://doi.org/10.1073/pnas.2002613117
https://doi.org/10.1073/pnas.2002613117
Publikováno v:
Biophysical Journal. 121:286a-287a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5d79f9e559a54ff666ac687875b1823
https://doi.org/10.1016/j.bpj.2021.11.1317
https://doi.org/10.1016/j.bpj.2021.11.1317