Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Megan L. Shipton"'
Autor:
María Ángeles Márquez-Moñino, Raquel Ortega-García, Hayley Whitfield, Andrew M. Riley, Lourdes Infantes, Shane W. Garrett, Megan L. Shipton, Charles A. Brearley, Barry V. L. Potter, Beatriz González
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract d-myo-inositol 1,4,5-trisphosphate (InsP3) is a fundamental second messenger in cellular Ca2+ mobilization. InsP3 3-kinase, a highly specific enzyme binding InsP3 in just one mode, phosphorylates InsP3 specifically at its secondary 3-hydroxy
Externí odkaz:
https://doaj.org/article/2e9f8695a0ad4929bc5af1359e3b8bdc
Autor:
Ji Qi, Weiwei Cheng, Zhe Gao, Yuanyuan Chen, Megan L. Shipton, David Furkert, Alfred C. Chin, Andrew M. Riley, Dorothea Fiedler, Barry V.L. Potter, Chenglai Fu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 161, Iss , Pp 114449- (2023)
The antifungal drug itraconazole has been repurposed to anti-angiogenic agent, but the mechanisms of action have been elusive. Here we report that itraconazole disrupts focal adhesion dynamics and cytoskeletal remodeling, which requires 5-diphosphoin
Externí odkaz:
https://doaj.org/article/aaf32d0eb0ef450baf10f427f23f6b17
Autor:
Megan L. Shipton, Fathima A. Jamion, Simon Wheeler, Andrew M. Riley, Felix Plasser, Barry V. L. Potter, Stephen J. Butler
Inositol pyrophosphates are important biomolecules associated with apoptosis, cell growth and kinase regulation, yet their exact biological roles are still emerging and probes do not exist for their selective detection. We report the first molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d893ea3969db0d29dd799bca647bc8bb
https://ora.ox.ac.uk/objects/uuid:ae15b87e-8207-4f06-aa58-69fd69316d1a
https://ora.ox.ac.uk/objects/uuid:ae15b87e-8207-4f06-aa58-69fd69316d1a
Autor:
Elsa Franco-Echevarría, Julia Sanz-Aparicio, Beatriz González, María Ángeles Márquez-Moñino, Barry V. L. Potter, Andrew M. Riley, Megan L. Shipton, Raquel Ortega-García
Publikováno v:
Science Advances
Digital.CSIC. Repositorio Institucional del CSIC
instname
'Science Advances ', vol: 7, pages: eabf6744-1-eabf6744-16 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
'Science Advances ', vol: 7, pages: eabf6744-1-eabf6744-16 (2021)
16 pags., 4 figs., 1 tab.
The yeast diadenosine and diphosphoinositol polyphosphate phosphohydrolase DDP1 is a Nudix enzyme with pyrophosphatase activity on diphosphoinositides, dinucleotides, and polyphosphates. These substrates bind to diverse
The yeast diadenosine and diphosphoinositol polyphosphate phosphohydrolase DDP1 is a Nudix enzyme with pyrophosphatase activity on diphosphoinositides, dinucleotides, and polyphosphates. These substrates bind to diverse
Autor:
Andrew M. Riley, Megan L. Shipton, Charles A. Brearley, Colin W. Taylor, Barry V. L. Potter, Ana M. Rossi
Publikováno v:
Journal of Medicinal Chemistry
Chiral sugar derivatives are potential cyclitol surrogates of the Ca2+-mobilizing intracellular messenger d-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]. Six novel polyphosphorylated analogues derived from both d- and l-glucose were synthesized. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b86de8579e66044c43db0bd2da75a48
https://ueaeprints.uea.ac.uk/id/eprint/74760/
https://ueaeprints.uea.ac.uk/id/eprint/74760/