Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Megan L. Sampley"'
Autor:
Megan L. Sampley, Sabire Özcan
Publikováno v:
DNA and Cell Biology. 31:8-14
Glucose-stimulated insulin gene transcription is mainly regulated by a 340-bp promoter region upstream of the transcription start site by beta-cell-enriched transcription factors Pdx-1, MafA, and NeuroD1. Previous studies have shown that histone H4 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3de7a3a60cecea51f1c80627ded9a4
https://doi.org/10.1089/dna.2011.1336
https://doi.org/10.1089/dna.2011.1336
Publikováno v:
Biochemical Journal. 415:1-10
Production and secretion of insulin from the beta-cells of the pancreas is very crucial in maintaining normoglycaemia. This is achieved by tight regulation of insulin synthesis and exocytosis from the beta-cells in response to changes in blood glucos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f4f0dff01504d86cfeb8ae738d6b13
https://doi.org/10.1042/bj20081029
https://doi.org/10.1042/bj20081029
Autor:
Raghavendra G. Mirmira, Aarthi V. Maganti, Megan L. Sampley, Sabire Özcan, Patrick M. Woster, Sarah A. Tersey, Boobalan Pachaiyappan, Chad S. Hunter, Bernhard Maier, Amber L. Mosley, Roland Stein
Background: Pdx1 interacts with the methyltransferase Set7/9 to transactivate β cell genes. Results: Methylation of Pdx1 residue Lys-131 by Set7/9 augments Pdx1 activity. Conclusion: The ability of Pdx1 to regulate genes in β cells is partially dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fbaa724dfb1060efa052eee7218d5f
https://europepmc.org/articles/PMC4392279/
https://europepmc.org/articles/PMC4392279/
Autor:
Austin L. Good, Marika M. Kachman, Bokkee Eun, Matthew T. Van Winkle, Karl Pfeifer, Megan L. Sampley
Publikováno v:
Nucleic Acids Research
In eukaryotic cells, gene expression is mediated by enhancer activation of RNA polymerase at distant promoters. Recently, distinctions between enhancers and promoters have been blurred by the discovery that enhancers are associated with RNA polymeras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc7173af1834ca5e997c9d221be08c4
https://pubmed.ncbi.nlm.nih.gov/23842673
https://pubmed.ncbi.nlm.nih.gov/23842673
Publikováno v:
Nucleic Acids Research
Developmentally regulated transcription often depends on physical interactions between distal enhancers and their cognate promoters. Recent genomic analyses suggest that promoter-promoter interactions might play a similarly critical role in organizin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d324c584e3249edcd6a1fd0d4b22b60
https://pubmed.ncbi.nlm.nih.gov/23221643
https://pubmed.ncbi.nlm.nih.gov/23221643
Publikováno v:
Topics in Current Genetics ISBN: 9783540209171
Glucose, the most preferred carbon source, also functions as a signaling molecule by stimulating the expression of metabolic genes in eukaryotes. In the yeast S. cerevisiae, transcription of metabolic genes such as those encoding glucose transporters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3258ed5d5fc87648023be22286394da0
https://doi.org/10.1007/978-3-540-39898-1_11
https://doi.org/10.1007/978-3-540-39898-1_11