Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Megan L. Koleske"'
Autor:
Sook Wah Yee, Luis Ferrández-Peral, Pol Alentorn-Moron, Claudia Fontsere, Merve Ceylan, Megan L. Koleske, Niklas Handin, Virginia M. Artegoitia, Giovanni Lara, Huan-Chieh Chien, Xujia Zhou, Jacques Dainat, Arthur Zalevsky, Andrej Sali, Colin M. Brand, Finn D. Wolfreys, Jia Yang, Jason E. Gestwicki, John A. Capra, Per Artursson, John W. Newman, Tomàs Marquès-Bonet, Kathleen M. Giacomini
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract SLC22A10 is an orphan transporter with unknown substrates and function. The goal of this study is to elucidate its substrate specificity and functional characteristics. In contrast to orthologs from great apes, human SLC22A10, tagged with gr
Externí odkaz:
https://doaj.org/article/a48ee6cda4514840ac818713e505c1b2
Autor:
Chetan P. Kulkarni, Jia Yang, Megan L. Koleske, Giovanni Lara, Khondoker Alam, Andre Raw, Bhagwant Rege, Liang Zhao, Dongmei Lu, Lei Zhang, Lawrence X. Yu, Robert A. Lionberger, Kathleen M. Giacomini, Deanna L. Kroetz, Sook Wah Yee
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 647 (2024)
The presence of mutagenic and carcinogenic N-nitrosamine impurities in medicinal products poses a safety risk. While incorporating antioxidants in formulations is a potential mitigation strategy, concerns arise regarding their interference with drug
Externí odkaz:
https://doaj.org/article/db2f7b3198274994a190b6df5cb02c07
Autor:
Jake M. Bieber, Laura E. Sanman, Xiaoxiao Sun, Heinz Hammerlindl, Feng Bao, Maike A. Roth, Megan L. Koleske, Liusheng Huang, Fran Aweeka, Lani F. Wu, Steven J. Altschuler
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Bieber et al use intestinal monolayers derived from fresh murine crypts as a model system to study drug toxicity. Testing 48 oncology drugs with known gastrointestinal toxicity as a proof of concept, they discover differential responses in cells from
Externí odkaz:
https://doaj.org/article/41ed1bb6411d4d969ca1025fa3f04d80
Autor:
Mark A. Munger, Yusuf Olğar, Megan L. Koleske, Heather L. Struckman, Jessica Mandrioli, Qing Lou, Ingrid Bonila, Kibum Kim, Roberto Ramos Mondragon, Silvia G. Priori, Pompeo Volpe, Héctor H. Valdivia, Joseph Biskupiak, Cynthia A. Carnes, Rengasayee Veeraraghavan, Sándor Györke, Przemysław B. Radwański
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 11 (2020)
Background Atrial fibrillation (AF) is a comorbidity associated with heart failure and catecholaminergic polymorphic ventricular tachycardia. Despite the Ca2+‐dependent nature of both of these pathologies, AF often responds to Na+ channel blockers.
Externí odkaz:
https://doaj.org/article/c3b12da609534a84822dec8d477ebd3b
Autor:
Megan L. Koleske, Xiaomin Liang, Osatohanmwen Jessica Enogieru, Dina Buitrago, Kathleen M. Giacomini
Publikováno v:
Drug Transporters. :9-32
Autor:
Megan L. Koleske, Gregory McInnes, Julia E. H. Brown, Neil Thomas, Keino Hutchinson, Marcus Y. Chin, Antoine Koehl, Michelle R. Arkin, Avner Schlessinger, Renata C. Gallagher, Yun S. Song, Russ B. Altman, Kathleen M. Giacomini
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 46
Genetic variants in SLC22A5 , encoding the membrane carnitine transporter OCTN2, cause the rare metabolic disorder Carnitine Transporter Deficiency (CTD). CTD is potentially lethal but actionable if detected early, with confirmatory diagnosis involvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c366924c8287c0c88448575f665b98d
https://escholarship.org/uc/item/3tq3c8f5
https://escholarship.org/uc/item/3tq3c8f5
Autor:
Ling Zou, Idit Kosti, Marina Sirota, Tomiko Oskotsky, Sebastian Jakobsen, Osatohanmwen J. Enogieru, Megan L. Koleske, Sook Wah Yee, Mattias Rödin, Bianca Vora, Kathleen M. Giacomini
Publikováno v:
Clinical Pharmacology and Therapeutics
Numerous drugs are currently under accelerated clinical investigation for the treatment of coronavirus disease 2019 (COVID‐19); however, well‐established safety and efficacy data for these drugs are limited. The goal of this study was to predict
Autor:
Kathleen M. Giacomini, Sook W. Yee, Megan L. Koleske, Ling Zou, Pär Matsson, Eugene C. Chen, Deanna L. Kroetz, Miles A. Miller, Elnaz Gozalpour, Xiaoyan Chu
Publikováno v:
Clinical pharmacology and therapeutics, vol 112, iss 3
Enabled by a plethora of new technologies, research in membrane transporters has exploded in the past decade. The goal of this state-of-the-art article is to describe recent advances in research on membrane transporters that are particularly relevant
Autor:
Barbara A. Koenig, Steven E. Brenner, Russ B. Altman, Gregory McInnes, Jodi Halpern, David Magnus, Sheng Wang, Aashish N. Adhikari, Megan L. Koleske, Renata C. Gallagher, Andrew G. Sharo, Kathleen M. Giacomini, Julia E.H. Brown, Matthew Norstad
Publikováno v:
American journal of human genetics, vol 108, iss 4
American Journal of Human Genetics
American Journal of Human Genetics
Summary Genome sequencing is enabling precision medicine—tailoring treatment to the unique constellation of variants in an individual’s genome. The impact of recurrent pathogenic variants is often understood, however there is a long tail of rare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a433117908dee100cd8bb1b9a46a185
https://escholarship.org/uc/item/0498z4kt
https://escholarship.org/uc/item/0498z4kt
Autor:
Derrick Chatad, Marina Sirota, Kathleen M. Giacomini, Huy X. Ngo, Sook Wah Yee, Megan L. Koleske, Osatohanmwen J. Enogieru, Bianca Vora
Publikováno v:
The AAPS journal, vol 23, iss 2
The AAPS Journal
The AAPS Journal
A rare cause of megaloblastic anemia (MA) is thiamine-responsive megaloblastic anemia (TRMA), a genetic disorder caused by mutations in SLC19A2 (encoding THTR1), a thiamine transporter. The study objectives were to (1) functionally characterize selec