Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Megan L. Burger"'
Autor:
Bashar Hamza, Alex B. Miller, Lara Meier, Max Stockslager, Sheng Rong Ng, Emily M. King, Lin Lin, Kelsey L. DeGouveia, Nolawit Mulugeta, Nicholas L. Calistri, Haley Strouf, Christina Bray, Felicia Rodriguez, William A. Freed-Pastor, Christopher R. Chin, Grissel C. Jaramillo, Megan L. Burger, Robert A. Weinberg, Alex K. Shalek, Tyler Jacks, Scott R. Manalis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Current methods for acquiring dissemination kinetics of rare circulating tumor cells (CTCs) that form metastases have several limitations. Here, the authors show an approach for measuring endogenous CTC kinetics by continuously exchanging CTC-contain
Externí odkaz:
https://doaj.org/article/a01832348b58404486e05ba5132c7532
Autor:
Simon Warchol, Robert Krueger, Ajit Johnson Nirmal, Giorgio Gaglia, Jared Jessup, Cecily C. Ritch, John Hoffer, Jeremy Muhlich, Megan L. Burger, Tyler Jacks, Sandro Santagata, Peter K. Sorger, Hanspeter Pfister
Publikováno v:
IEEE Trans Vis Comput Graph
New highly-multiplexed imaging technologies have enabled the study of tissues in unprecedented detail. These methods are increasingly being applied to understand how cancer cells and immune response change during tumor development, progression, and m
Autor:
Giorgio Gaglia, Megan L. Burger, Cecily C. Ritch, Danae Rammos, Yang Dai, Grace E. Crossland, Sara Z. Tavana, Simon Warchol, Alex M. Jaeger, Santiago Naranjo, Shannon Coy, Ajit J. Nirmal, Robert Krueger, Jia-Ren Lin, Hanspeter Pfister, Peter K Sorger, Tyler Jacks, Sandro Santagata
Publikováno v:
Cancer Cell. 41:871-886.e10
Lymphocytes play a key role in immune surveillance of tumors, but our understanding of the spatial organization and physical interactions that facilitate lymphocyte anti-cancer functions is limited. Here, we used multiplexed imaging, quantitative spa
Autor:
Megan L. Burger, Giorgio Gaglia, Claire C. Ritch, Danae Rammos, Yang Dai, Grace E. Crossland, Sara Z. Tavana, Simon Warchol, Alex M. Jaeger, Santiago Naranjo, Shannon Coy, Ajit J. Nirmal, Robert Krueger, Jia-Ren Lin, Hanspeter Pfister, Peter K. Sorger, Tyler Jacks, Sandro Santagata
Publikováno v:
Cancer Research. 83:5877-5877
Cancer immunotherapies that activate cytotoxic T cell responses against tumors have been remarkably effective in some patients, but the determinants of response remain unclear. To investigate how spatial organization of T cells might influence immuno
Publikováno v:
The American Surgeon. :000313482211469
Background Wide excision (WE) to muscular fascia for invasive melanoma is common practice but excision to subcutaneous tissue may be adequate. We evaluated practice patterns regarding depth of biopsy and excision as well as risks for recurrence. Meth
Autor:
Jason M. Schenkel, Sara Z. Tavana, Michelle Hillman, Peter M. K. Westcott, Megan L. Burger, Sarah E. Blatt, Tyler Jacks, David Canner, Marta M. Holovatska, Michael Manos, Giorgio Gaglia, Izumi de los Rios Kobara, Aviv Regev, Alex M. Jaeger, Arjun Bhutkar, Sandro Santagata, William L. Hwang, F. Stephen Hodi, Cecily C. Ritch, Amanda M. Cruz, Tamina Kienka, Andrea Garmilla, Alexia L. Barandiaran, Amy Li, Grace E. Crossland
Publikováno v:
Cell
Summary CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is known about the interplay between responses and its impact on T cell function and tumor control. In mouse lung adenocarcinoma, we found that immunodo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881da5a74e035825ca947128bb7a8b0b
https://europepmc.org/articles/PMC8522630/
https://europepmc.org/articles/PMC8522630/
Autor:
William L. Hwang, Megan L. Burger, Orit Rozenblatt-Rosen, Le Cong, Michael S. Cuoco, Tyler Jacks, Jonathan Y. Kim, David Canner, George Eng, Amy Li, Sean-Luc Shanahan, Peter M. K. Westcott, Olivia Smith, Patricia Rogers, Rebecca H. Herbst, Kristen E. Pauken, Grace Gibbons, Aviv Regev, Jason M. Schenkel, Jin K. Park, Michelle Hillman, William A. Freed-Pastor
Publikováno v:
Immunity
In tumors, a subset of CD8(+) T cells expressing the transcription factor TCF-1 drives the response to immune checkpoint blockade. We examined the mechanisms that maintain these cells in an autochthonous model of lung adenocarcinoma. Longitudinal sam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4e9ed93c4fcd85dd5b84259ce61603
https://europepmc.org/articles/PMC8604155/
https://europepmc.org/articles/PMC8604155/
Publikováno v:
eLife, Vol 3 (2014)
T cell self-tolerance is thought to involve peripheral tolerance and negative selection, involving apoptosis of autoreactive thymocytes. However, evidence supporting an essential role for negative selection is limited. Loss of Bim, a Bcl-2 BH3-only p
Externí odkaz:
https://doaj.org/article/c5738485ef0b481f8047126c3e357172
Autor:
Sarah E. Blatt, Izumi de los Rios Kobara, Aviv Regev, Arjun Bhutkar, David Canner, Sandro Santagata, Sara Z. Tavana, Amy Li, Jason M. Schenkel, Tyler Jacks, Grace E. Crossland, Michelle Hillman, Tamina Kienka, Peter M. K. Westcott, Andrea Garmilla, Giorgio Gaglia, William L. Hwang, Megan L. Burger, Cecily C. Ritch, Amanda M. Cruz
Publikováno v:
SSRN Electronic Journal.
CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is known about their interplay and its impact on T cell function and tumor control. In mouse lung adenocarcinoma, we find that immunodominance is established in
Autor:
Jonathan Y. Kim, Jason M. Schenkel, Jin K. Park, Tyler Jacks, Aviv Regev, Kristen E. Pauken, Peter M. K. Westcott, George Eng, Michelle Hillman, David Canner, Orit Rozenblatt-Rosen, William A. Freed-Pastor, Amy Li, Megan L. Burger, Patricia Rogers, Rebecca H. Herbst, Olivia Smith, Le Cong, William L. Hwang, Mike Cuoco
Publikováno v:
SSRN Electronic Journal.
During chronic antigen stimulation, CD8+ T cells lose their effector potential. Because much of our understanding of anti-tumor T cell dysfunction comes from shorter-term transplantable models, it is less clear how dysfunction shifts over time in tum