Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Megan L Wojciechowicz"'
Autor:
Minji Jeon, Zhuorui Xie, John E. Evangelista, Megan L. Wojciechowicz, Daniel J. B. Clarke, Avi Ma’ayan
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-18 (2022)
Abstract The L1000 technology, a cost-effective high-throughput transcriptomics technology, has been applied to profile a collection of human cell lines for their gene expression response to > 30,000 chemical and genetic perturbations. In total, ther
Externí odkaz:
https://doaj.org/article/f89bbb4138654da9a599cd18de174665
Autor:
Daniel J. B. Clarke, Alison W. Rebman, Allison Bailey, Megan L. Wojciechowicz, Sherry L. Jenkins, John E. Evangelista, Matteo Danieletto, Jinshui Fan, Mark W. Eshoo, Michael R. Mosel, William Robinson, Nitya Ramadoss, Jason Bobe, Mark J. Soloski, John N. Aucott, Avi Ma'ayan
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Although widely prevalent, Lyme disease is still under-diagnosed and misunderstood. Here we followed 73 acute Lyme disease patients and uninfected controls over a period of a year. At each visit, RNA-sequencing was applied to profile patients' periph
Externí odkaz:
https://doaj.org/article/e92b23e3f97e46118a0d27aa2c7cacfd
Autor:
John Erol Evangelista, Daniel J B Clarke, Zhuorui Xie, Alexander Lachmann, Minji Jeon, Kerwin Chen, Kathleen M Jagodnik, Sherry L Jenkins, Maxim V Kuleshov, Megan L Wojciechowicz, Stephan C Schürer, Mario Medvedovic, Avi Ma’ayan
Publikováno v:
Nucleic Acids Research. 50:W697-W709
Millions of transcriptome samples were generated by the Library of Integrated Network-based Cellular Signatures (LINCS) program. When these data are processed into searchable signatures along with signatures extracted from Genotype-Tissue Expression
Autor:
Giacomo B Marino, Megan L Wojciechowicz, Daniel J B Clarke, Maxim V Kuleshov, Zhuorui Xie, Minji Jeon, Alexander Lachmann, Avi Ma’ayan
Publikováno v:
Database. 2023
Long non-coding ribonucleic acids (lncRNAs) account for the largest group of non-coding RNAs. However, knowledge about their function and regulation is limited. lncHUB2 is a web server database that provides known and inferred knowledge about the fun
Autor:
Zhuorui Xie, Eryk Kropiwnicki, Megan L. Wojciechowicz, Kathleen M. Jagodnik, Ingrid Shu, Allison Bailey, Daniel J. B. Clarke, Minji Jeon, John Erol Evangelista, Maxim V. Kuleshov, Alexander Lachmann, Abhijna A. Parigi, Jose M. Sanchez, Sherry L. Jenkins, Avi Ma'ayan
Publikováno v:
Curr Protoc
The Library of Integrated Network-based Cellular Signatures (LINCS) was an NIH Common Fund program that aimed to expand our knowledge about human cellular responses to chemical, genetic, and microenvironment perturbations. Responses to perturbations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f256238f0af6392ddf5435b3fd6853
https://europepmc.org/articles/PMC9326873/
https://europepmc.org/articles/PMC9326873/
Autor:
Alexander Lachmann, Kathleen M. Jagodnik, Sherry L. Jenkins, Avi Ma'ayan, Megan L. Wojciechowicz, Alexandra B Keenan, Zichen Wang
Publikováno v:
Annual Review of Biomedical Data Science. 2:69-92
Connectivity mapping resources consist of signatures representing changes in cellular state following systematic small-molecule, disease, gene, or other form of perturbations. Such resources enable the characterization of signatures from novel pertur
Autor:
Denis Torre, Kathleen M. Jagodnik, Megan L. Wojciechowicz, Alexander Lachmann, Vivian Utti, Zichen Wang, Avi Ma'ayan, Alexandra B Keenan, Ariel K Leong, Eryk Kropiwnicki
Publikováno v:
Nucleic Acids Research
Identifying the transcription factors (TFs) responsible for observed changes in gene expression is an important step in understanding gene regulatory networks. ChIP-X Enrichment Analysis 3 (ChEA3) is a transcription factor enrichment analysis tool th
Autor:
Megan L. Wojciechowicz, Alexandra B Keenan, Denis Torre, Maxim V. Kuleshov, Alexander Lachmann, Brian M. Schilder, Avi Ma'ayan
Publikováno v:
Nucleic Acids Research
W577
W571
W577
W571
The frequency by which genes are studied correlates with the prior knowledge accumulated about them. This leads to an imbalance in research attention where some genes are highly investigated while others are ignored. Geneshot is a search engine devel
Autor:
Mark W. Eshoo, Avi Ma'ayan, William H. Robinson, Jinshui Fan, Michael R. Mosel, John Erol Evangelista, Matteo Danieletto, Allison Bailey, Megan L. Wojciechowicz, Nitya S. Ramadoss, Jason Bobe, Alison W. Rebman, Mark J. Soloski, John N. Aucott, Sherry L. Jenkins, Daniel J.B. Clarke
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Although widely prevalent, Lyme disease is still under-diagnosed and misunderstood. Here we followed 73 acute Lyme disease patients and uninfected controls over a period of a year. At each visit, RNA-sequencing was applied to profile patients' periph
Autor:
Avi Ma'ayan, Megan L. Wojciechowicz, Zhengzhe Li, John Cijiang He, Lu Zhang, Kyung Lee, Jennifer Lin, Jiyi Huang, Ruijie Liu, Zichen Wang
Publikováno v:
Diabetes
Diabetic kidney disease (DKD) remains the most common cause of kidney failure, and the treatment options are insufficient. Here, we used a connectivity mapping approach to first collect 15 gene expression signatures from 11 DKD-related published inde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636e00027533271207c056ba6e18c5d7
https://doi.org/10.2337/figshare.13061864.v1
https://doi.org/10.2337/figshare.13061864.v1