Výsledky vyhledávání - "Megan L Finch"

Akademický článek

A modified choline-deficient, ethionine-supplemented diet reduces morbidity and retains a liver progenitor cell response in mice

Autor: Adam M. Passman, Robyn P. Strauss, Sarah B. McSpadden, Megan L. Finch-Edmondson, Ken H. Woo, Luke A. Diepeveen, Roslyn London, Bernard A. Callus, George C. Yeoh

Publikováno v: Disease Models & Mechanisms, Vol 8, Iss 12, Pp 1635-1641 (2015)

The choline-deficient, ethionine-supplemented (CDE) dietary model induces chronic liver damage, and stimulates liver progenitor cell (LPC)-mediated repair. Long-term CDE administration leads to hepatocellular carcinoma in rodents and lineage-tracing

Externí odkaz: https://doaj.org/article/590a223ebd954ff28931048224c8ef47

Zobrazit plný text záznamu

Akademický článek

Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins.

Autor: Katharine J Goodall, Megan L Finch-Edmondson, Joanne van Vuuren, George C Yeoh, Ian E Gentle, James E Vince, Paul G Ekert, David L Vaux, Bernard A Callus

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0164003 (2016)

Apoptosis mediated by Bax or Bak is usually thought to be triggered by BH3-only members of the Bcl-2 protein family. BH3-only proteins can directly bind to and activate Bax or Bak, or indirectly activate them by binding to anti-apoptotic Bcl-2 family

Externí odkaz: https://doaj.org/article/10cbdea384e44e65aaebf41fbee23257

Zobrazit plný text záznamu

Akademický článek

Sub-cellular localisation studies may spuriously detect the Yes-associated protein, YAP, in nucleoli leading to potentially invalid conclusions of its function.

Autor: Megan L Finch, Adam M Passman, Robyn P Strauss, George C Yeoh, Bernard A Callus

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0114813 (2015)

The Yes-associated protein (YAP) is a potent transcriptional co-activator that functions as a nuclear effector of the Hippo signaling pathway. YAP is oncogenic and its activity is linked to its cellular abundance and nuclear localisation. Activation

Externí odkaz: https://doaj.org/article/a18ed646f0b24c7bb5871055161104fd

Zobrazit plný text záznamu

Regulation of microRNAs and their role in liver development, regeneration and disease

Autor: George C.T. Yeoh, Jens U. Marquardt, Megan L. Finch, Bernard A. Callus

Publikováno v: The International Journal of Biochemistry & Cell Biology. 54:288-303

Since their discovery more than a decade ago microRNAs have been demonstrated to have profound effects on almost every aspect of biology. Numerous studies in recent years have shown that microRNAs have important roles in development and in the etiolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576805261ce9b5cae21f577543c76d7e
https://doi.org/10.1016/j.biocel.2014.04.002

Zobrazit plný text záznamu