Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Megan K. Le"'
Publikováno v:
bioRxiv
Ancient DNA has revolutionized our understanding of human population history. However, its potential to examine how rapid cultural evolution to new lifestyles may have driven biological adaptation has not been met, largely due to limited sample sizes
Autor:
Gabrielle N. Gaultier, Brynn McMillan, Chad Poloni, Mandy Lo, Bing Cai, Jean J. Zheng, Hannah M. Baer, Hennady P. Shulha, Karen Simmons, Ana Citlali Márquez, Sofia R. Bartlett, Laura Cook, Megan K. Levings, Theodore Steiner, Inna Sekirov, James E. A. Zlosnik, Muhammad Morshed, Danuta M. Skowronski, Mel Krajden, Agatha N. Jassem, Manish Sadarangani
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract To evaluate immune responses to COVID-19 vaccines in adults aged 50 years and older, spike protein (S)-specific antibody concentration, avidity, and function (via angiotensin-converting enzyme 2 (ACE2) inhibition surrogate neutralization and
Externí odkaz:
https://doaj.org/article/b21ce8f9399a4f10afbf41b7b7c5bfbe
Autor:
Isaac Rosado-Sánchez, Manjurul Haque, Kevin Salim, Madeleine Speck, Vivian C.W. Fung, Dominic A. Boardman, Majid Mojibian, Giorgio Raimondi, Megan K. Levings
Publikováno v:
JCI Insight, Vol 8, Iss 19 (2023)
Tregs expressing chimeric antigen receptors (CAR-Tregs) are a promising tool to promote transplant tolerance. The relationship between CAR structure and Treg function was studied in xenogeneic, immunodeficient mice, revealing advantages of CD28-encod
Externí odkaz:
https://doaj.org/article/cf2c48e413f44ef8a6d17ff698bc1b5b
Autor:
Justin A. Spanier, Vivian Fung, Christine M. Wardell, Mohannad H. Alkhatib, Yixin Chen, Linnea A. Swanson, Alexander J. Dwyer, Matthew E. Weno, Nubia Silva, Jason S. Mitchell, Paul C. Orban, Majid Mojibian, C. Bruce Verchere, Brian T. Fife, Megan K. Levings
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Adoptive immunotherapy with Tregs is a promising approach for preventing or treating type 1 diabetes. Islet antigen–specific Tregs have more potent therapeutic effects than polyclonal cells, but their low frequency is a barrier for clinical applica
Externí odkaz:
https://doaj.org/article/07b12edb27a645e0ba884c7c896ee39b
Publikováno v:
Advanced Materials Interfaces, Vol 10, Iss 8, Pp n/a-n/a (2023)
Abstract Non‐volatile memory device structures such as ferroelectric random‐access memory and ferroelectric tunnel junctions employ switchable spontaneous polarization to hold binary states. These devices can potentially benefit from the impositi
Externí odkaz:
https://doaj.org/article/d76d51da89ed41579861b8ecfab648ef
Autor:
Sarah J. Colpitts, Matthew A. Budd, Mahdis Monajemi, Kyle T. Reid, Julia M. Murphy, Sabine Ivison, C. Bruce Verchere, Megan K. Levings, Sarah Q. Crome
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Defining the immunological landscape of human tissue is an important area of research, but challenges include the impact of tissue disaggregation on cell phenotypes and the low abundance of immune cells in many tissues. Here, we describe methods to t
Externí odkaz:
https://doaj.org/article/a3403a527ce5473e87c809b9fafea3b5
Autor:
Madeline Lauener, Shima AzadPour, Sayeh Abdossamadi, Vaishnavi Parthasarathy, Bernard Ng, Elena Ostroumov, Geoffrey D.E. Cuvelier, Megan K. Levings, Katherine N. MacDonald, Amina Kariminia, Kirk R. Schultz
Publikováno v:
Haematologica, Vol 108, Iss 3 (2022)
Chronic graft-versus-host disease (cGvHD) is a major cause of morbidity after hematopoietic stem cell transplantation (HSCT). In large patient populations, we have shown a CD56bright natural killer (NK) population to strongly associate with a lack of
Externí odkaz:
https://doaj.org/article/0805d20a5cc146f1bde30729006f4f9f
Autor:
Elaine F. Reed, Anita S. Chong, Megan K. Levings, Caley Mutrie, Terri M. Laufer, Maria Grazia Roncarolo, Megan Sykes
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The authors of this article, all women who have been deeply committed to the Federation of Clinical Immunology Societies (FOCIS), performed a retrospective analysis of gender equality practices of FOCIS to identify areas for improvement and make reco
Externí odkaz:
https://doaj.org/article/c66027c8cc2b47e899ca6620e7ae4a8a
Autor:
Laura Cook, Daniel J. Lisko, May Q. Wong, Rosa V. Garcia, Megan E. Himmel, Ernest G. Seidman, Brian Bressler, Megan K. Levings, Theodore S. Steiner
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 485-506 (2020)
Background & Aims: Bacterial flagellin is an important antigen in inflammatory bowel disease, but the role of flagellin-specific CD4+ T cells in disease pathogenesis remains unclear. Also unknown is how changes in intestinal microbiome intersect with
Externí odkaz:
https://doaj.org/article/63c7574960da43a49aefc4bb623932ef
Autor:
Allison E. Kennedy, Laura Cook, Jessica A. Breznik, Braeden Cowbrough, Jessica G. Wallace, Angela Huynh, James W. Smith, Kiho Son, Hannah Stacey, Jann Ang, Allison McGeer, Brenda L. Coleman, Maggie Larché, Mark Larché, Nathan Hambly, Parameswaran Nair, Kjetil Ask, Matthew S. Miller, Jonathan Bramson, Megan K. Levings, Ishac Nazy, Sarah Svenningsen, Manali Mukherjee, Dawn M. E. Bowdish
Publikováno v:
Viruses, Vol 13, Iss 11, p 2239 (2021)
Survivors of severe SARS-CoV-2 infections frequently suffer from a range of post-infection sequelae. Whether survivors of mild or asymptomatic infections can expect any long-term health consequences is not yet known. Herein we investigated lasting ch
Externí odkaz:
https://doaj.org/article/8f7c4fc913cd40b49c927684c3a33237