Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Megan K. Elder"'
Autor:
Mauricio M. Oliveira, Muhaned Mohamed, Megan K. Elder, Keylin Banegas-Morales, Maggie Mamcarz, Emily H. Lu, Ela A.N. Golhan, Nishika Navrange, Snehajyoti Chatterjee, Ted Abel, Eric Klann
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113670- (2024)
Summary: Neuronal protein synthesis is required for long-lasting plasticity and long-term memory consolidation. Dephosphorylation of eukaryotic initiation factor 2α is one of the key translational control events that is required to increase de novo
Externí odkaz:
https://doaj.org/article/ec977505ce0440bead73395783f6d0fd
Autor:
Megan K. Elder, Hediye Erdjument-Bromage, Mauricio M. Oliveira, Maggie Mamcarz, Thomas A. Neubert, Eric Klann
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Elder et al. investigated the de novo proteome in isolated hippocampal slices of young APP/PS1 Alzheimer’s model mice and revealed that large-scale changes in protein synthesis precede symptom onset. These results suggest that broad dysregulation o
Externí odkaz:
https://doaj.org/article/ba83267e1a204a7482de629bf9b21435
Autor:
Rhys W. Livingstone, Megan K. Elder, Anurag Singh, Courteney M. Westlake, Warren P. Tate, Wickliffe C. Abraham, Joanna M. Williams
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Regulation of AMPA receptor expression by neuronal activity and neuromodulators is critical to the expression of both long-term potentiation (LTP) and memory. In particular, Ca2+-permeable AMPARs (CP-AMPAR) play a unique role in these processes due t
Externí odkaz:
https://doaj.org/article/9290877e3a9240328cd488775be4af9a
Autor:
Rhys W. Livingstone, Megan K. Elder, Maya C. Barrett, Courteney M. Westlake, Katie Peppercorn, Warren P. Tate, Wickliffe C. Abraham, Joanna M. Williams
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Secreted amyloid precursor protein-α (sAPPα) is a neuroprotective and memory-enhancing molecule, however, the mechanisms through which sAPPα promotes these effects are not well understood. Recently, we have shown that sAPPα enhances cell-surface
Externí odkaz:
https://doaj.org/article/d8621d86ccc64b138cfd845ca9e51ebf
Autor:
Mauricio M. Oliveira, Megan K. Elder, Thomas A. Neubert, Hediye Erdjument-Bromage, Eric Klann, Maggie Mamcarz
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology
Communications Biology
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder associated with memory loss, but the AD-associated neuropathological changes begin years before memory impairments. Investigation of the early molecular abnormalities in AD might
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90b34d239a88efb594b79bd905a57e1
https://doaj.org/article/ba83267e1a204a7482de629bf9b21435
https://doaj.org/article/ba83267e1a204a7482de629bf9b21435
Autor:
Megan K. Elder, Aline Loehfelm, Alexander Tups, Peter P. Jones, Joanna M. Williams, Alisa Boucsein
Publikováno v:
The FASEB Journal. 34:4635-4652
The importance of fatty acids (FAs) for healthy brain development and function has become more evident in the past decades. However, most studies focus on the hypothalamus as an important FA-sensing brain region involved in energy homeostasis. Less w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629f906be82bbb203eb032d0c518a62c
https://doi.org/10.1096/fj.201902517r
https://doi.org/10.1096/fj.201902517r
Autor:
Eric Klann, Maggie Mamcarz, Megan K. Elder, Thomas A. Neubert, Hediye Erdjument-Bromage, Mauricio M. Oliveira
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder, but neuropathological changes in AD begin years before memory impairment. Investigation of the early molecular abnormalities in AD might offer innovative opportunities to target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c34bb63148fb41e9699ed4a5ed13462
https://doi.org/10.1101/2020.08.21.260786
https://doi.org/10.1101/2020.08.21.260786
Autor:
Joanna M. Williams, Warren P. Tate, Rhys Warren Livingstone, Megan K. Elder, Katie Peppercorn, Maya Colleen Barrett, Courteney Margaret Westlake, Wickliffe C. Abraham
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
Secreted amyloid precursor protein-α (sAPPα) is a neuroprotective and memory-enhancing molecule, however, the mechanisms through which sAPPα promotes these effects are not well understood. Recently, we have shown that sAPPα enhances cell-surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5600d1f3cad48bd89a5b77ffae62eee
https://www.frontiersin.org/article/10.3389/fnmol.2019.00198/full
https://www.frontiersin.org/article/10.3389/fnmol.2019.00198/full
Autor:
Stefan Liebau, Sara K. Young-Baird, Thomas E. Dever, Megan K. Elder, Eric Klann, Maíra Bertolessi Lourenço
Publikováno v:
Mol Cell
Summary Dysregulation of cellular protein synthesis is linked to a variety of diseases. Mutations in EIF2S3, encoding the γ subunit of the heterotrimeric eukaryotic translation initiation factor eIF2, cause MEHMO syndrome, an X-linked intellectual d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2746f44966b41e628ddaaf94e12bb36
https://doi.org/10.1016/j.molcel.2019.11.008
https://doi.org/10.1016/j.molcel.2019.11.008
Autor:
Bruce G. Mockett, Susanne tom Dieck, Jodi A. Morrissey, Megan K. Elder, Wickliffe C. Abraham, Anurag K. Singh, Karen D. Parfitt, Lisa Kochen, Diane Guévremont, Timothy J. Hintz, Warren P. Tate, Erin M. Schuman, Joanna M. Williams, Katie Peppercorn
Publikováno v:
The Journal of Neuroscience
Secreted amyloid precursor protein-alpha (sAPPα) has growth factor-like properties and can modulate long-term potentiation (LTP) and memory. Here, we demonstrate that exposure to sAPPα converts short-lasting LTP into protein-synthesis-dependent lat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8461172fd5469c1ed857f10fb7965f10
https://pubmed.ncbi.nlm.nih.gov/30804097
https://pubmed.ncbi.nlm.nih.gov/30804097