Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Megan J. Heath"'
Autor:
David Venzon, Marjorie Robert-Guroff, David H. O’Connor, Ruth H. Florese, Fausto Titti, Ranajit Pal, L. Jean Patterson, Megan J. Heath, Vaniambadi S. Kalyanaraman, Thorsten Demberg, Aurelio Cafaro, Roger W. Wiseman, Leon Flanary, Julie A. Karl, Kay Larsen, Barbara Ensoli
Publikováno v:
Vaccine. 26:3312-3321
Protection afforded by HIV Tat-based vaccines has differed in Indian rhesus and Mauritian cynomolgus macaques. We evaluated native Tat and Ad-HIVtat priming/Tat-boosting regimens in both species. Both vaccines were immunogenic. Only the Ad-tat regime
Autor:
L. Jean Patterson, Vaniambadi S. Kalyanaraman, Thorsten Demberg, Megan J. Heath, Kay Larsen, Norman L. Letvin, Birgit Korioth-Schmitz, Irene Kalisz, Adam P. Buzby, Eun Mi Lee, David Venzon, Barbara Ensoli, Richard Grant, Ruth H. Florese, Aurelio Cafaro, Dilani Dombagoda, Ranajit Pal, David C. Montefiori, Marjorie Robert-Guroff
Publikováno v:
Journal of Virology. 81:3414-3427
We previously demonstrated that replication-competent adenovirus (Ad)-simian immunodeficiency virus (SIV) recombinant prime/protein boost regimens elicit potent immunogenicity and strong, durable protection of rhesus macaques against SIVmac251. Addit
Publikováno v:
Journal of Biological Chemistry. 278:30755-30763
The replication process of human immunodeficiency virus requires a number of nucleic acid annealing steps facilitated by the hybridization and helix-destabilizing activities of human immunodeficiency virus nucleocapsid (NC) protein. NC contains two C
Publikováno v:
Journal of Biological Chemistry. 278:15702-15712
An in vitro strand transfer assay that mimicked recombinational events occurring during reverse transcription in HIV-1 was used to assess the role of nucleocapsid protein (NC) in strand transfer. Strand transfer in highly structured nucleic acid spec
Autor:
Megan J. Heath, Jeffrey J. DeStefano
Publikováno v:
Biochemistry. 44(10)
Enhancement of strand exchange by nucleocapsid protein (NC) is proposed to occur during retroviral recombination. The mechanism was examined using an RNA (donor)-DNA hybrid that mimicked a retrovirus replication intermediate. This consisted of a 25 b