Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Megan J, Larmore"'
1
Neprilysin inhibition improves intravenous but not oral glucose-mediated insulin secretion via GLP-1R signaling in mice with
Autor: Nathalie, Esser, Stephen M, Mongovin, Jacqueline, Parilla, Breanne M, Barrow, Thomas O, Mundinger, Brendy S, Fountaine, Megan J, Larmore, Joseph J, Castillo, Rehana, Akter, Rebecca L, Hull, Sakeneh, Zraika
Publikováno v: Am J Physiol Endocrinol Metab
Type 2 diabetes is associated with the upregulation of neprilysin, a peptidase capable of cleaving glucoregulatory peptides such as glucagon-like peptide-1 (GLP-1). In humans, use of the neprilysin inhibitor sacubitril in combination with an angioten
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c8fb8c338ce71d519f28c580d56881f
https://pubmed.ncbi.nlm.nih.gov/35128957
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2
Neprilysin inhibition improves intravenous but not oral glucose-mediated insulin secretion via GLP-1R signaling in mice with β-cell dysfunction
Autor: Nathalie Esser, Stephen M. Mongovin, Jacqueline Parilla, Breanne M. Barrow, Thomas O. Mundinger, Brendy S. Fountaine, Megan J. Larmore, Joseph J. Castillo, Rehana Akter, Rebecca L. Hull, Sakeneh Zraika
Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 322:E307-E318
The neprilysin inhibitor, sacubitril, improves glycemic status in a mouse model of reduced insulin secretion. Sacubitril enhances intravenous but not oral glucose-mediated insulin secretion. The increased glucose-mediated insulin secretion is GLP-1 r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b7a38cdff715869db9c71f679e2e833
https://doi.org/10.1152/ajpendo.00234.2021
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3
SGLT2-i improves markers of islet endothelial cell function in db/db diabetic mice
Autor: Sakeneh Zraika, Alfred C Aplin, Daryl J. Hackney, Rebecca L. Hull, Joseph J Castillo, Megan J. Larmore, Thomas O. Mundinger, Meghan F Hogan, Nathalie Esser
Publikováno v: J Endocrinol
Islet endothelial cells produce paracrine factors important for islet beta-cell function and survival. Under conditions of type 2 diabetes, islet endothelial cells exhibit a dysfunctional phenotype including increased expression of genes involved in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9abeceb549583f6200e95a9df6c1c1
https://doi.org/10.1530/joe-20-0354
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4
Fibroinflammatory Signatures Increase with Age in the Human Ovary and Follicular Fluid
Autor: Francesca E. Duncan, Michele T. Pritchard, John M. Kelsh, Megan J. Larmore, Seth J. Barishansky, Brian W. Johnson, Jordan H. Machlin, Mary Ellen Pavone
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4902, p 4902 (2021)
The female reproductive system ages before any other organ system in the body. This phenomenon can have tangible clinical implications leading to infertility, miscarriages, birth defects and systemic deterioration due to estrogen loss. “Fibroinflam
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a999664b75717ce07cb74729639ee42
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5
Sphingosine-1-phosphate and its mimetic FTY720 do not protect against radiation-induced ovarian fibrosis in the nonhuman primate†
Autor: Mary B. Zelinski, Francesca E. Duncan, Sharrón L. Manuel, Farners Amargant, Brian W. Johnson, Michele T. Pritchard, Maralee S. Lawson, Megan J. Larmore
Publikováno v: Biol Reprod
Oocytes are highly radiosensitive, so agents that prevent radiation-induced ovarian follicle destruction are important fertility preservation strategies. A previous study in rhesus macaques demonstrated that ovarian treatment with antiapoptotic agent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802a03c1873d7a4d17ec9ab0e818100d
https://pubmed.ncbi.nlm.nih.gov/33524104
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6
Hyaluronan deposition in islets may precede and direct the location of islet immune cell infiltrates
Autor: Pamela Y. Johnson, Thomas N. Wight, Åke Lernmark, Marika Bogdani, Cate Speake, Mathew J. Dufort, Carla J. Greenbaum, Anthony J. Day, Megan J. Larmore
Publikováno v: Bogdani, M, Speake, C, Dufort, M J, Johnson, P Y, Larmore, M J, Day, A, Wight, T N, Lernmark, A & Greenbaum, C J 2020, ' Hyaluronan deposition in islets may precede and direct the location of islet immune cell infiltrates ', Diabetologia . https://doi.org/10.1007/s00125-019-05066-7
Diabetologia
AIMS/HYPOTHESIS: Substantial deposition of the extracellular matrix component hyaluronan (HA) is characteristic of insulitis in overt type 1 diabetes. We investigated whether HA accumulation is detectable in islets early in disease pathogenesis and h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd20a18bb2f3519af7aabdb62be51f92
https://www.research.manchester.ac.uk/portal/en/publications/hyaluronan-deposition-in-islets-may-precede-and-direct-the-location-of-islet-immune-cell-infiltrates(e2c28047-c006-4afa-9313-4dad04a89936).html
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7
Ovulation and ovarian wound healing are impaired with advanced reproductive age
Autor: Francesca E. Duncan, Michele T. Pritchard, Jamie N. Mara, Rebecca Ayiku, Megan J. Larmore, Brian Johnson, Luhan T. Zhou, Farners Amargant
Publikováno v: Aging (Albany NY)
Aging is associated with reduced tissue remodeling efficiency and increased fibrosis, characterized by excess collagen accumulation and altered matrix degradation. Ovulation, the process by which an egg is released from the ovary, is one of the most
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da09a7150ea89d074af0f08c9948ea3
https://pubmed.ncbi.nlm.nih.gov/32407290
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