A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome

Autor: Ruud P. H. Raijmakers, Anne F. M. Jansen, Stephan P. Keijmel, Rob ter Horst, Megan E. Roerink, Boris Novakovic, Leo A. B. Joosten, Jos W. M. van der Meer, Mihai G. Netea, Chantal P. Bleeker-Rovers

Publikováno v: Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-10 (2019)

Abstract Background Q fever fatigue syndrome (QFS) is a well-documented state of prolonged fatigue following around 20% of acute Q fever infections. It has been hypothesized that low grade inflammation plays a role in its aetiology. In this study, we

Externí odkaz: https://doaj.org/article/640b12f2af00423eb64f4c3b5ef44c17

No Signs of Neuroinflammation in Women With Chronic Fatigue Syndrome or Q Fever Fatigue Syndrome Using the TSPO Ligand [11C]-PK11195

Autor: Ruud P. H. Raijmakers, Mihai G. Netea, Megan E. Roerink, Jos W. M. van der Meer, Stephan P. Keijmel, Janine Doorduin, Chantal P. Bleeker-Rovers, Leo A. B. Joosten, Hans C. Klein, Hans Knoop

Publikováno v: Neurology-Neuroimmunology & neuroinflammation, 9(1):e1113. LIPPINCOTT WILLIAMS & WILKINS
Neurology® neuroimmunology & neuroinflammation, 9(1). Lippincott Williams and Wilkins
Neurology: Neuroimmunology & Neuroinflammation, 9
Neurology® Neuroimmunology & Neuroinflammation
article-version (Version of Record) 3
Neurology: Neuroimmunology & Neuroinflammation, 9, 1

Background and ObjectivesThe pathophysiology of chronic fatigue syndrome (CFS) and Q fever fatigue syndrome (QFS) remains elusive. Recent data suggest a role for neuroinflammation as defined by increased expression of translocator protein (TSPO). In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a7a709d5a69839f6879382a4a6a4b3
https://research.rug.nl/en/publications/97d91983-910c-486e-bdb6-e4639141dd5f

Multi-omics Examination of Q Fever Fatigue Syndrome Identifies Similarities with Chronic Fatigue Syndrome

Autor: Chantal P. Bleeker-Rovers, Leo A. B. Joosten, Cheng-Jian Xu, Mihai G. Netea, Yang Li, Megan E. Roerink, Anne F.M. Jansen, Jos W. M. van der Meer, Ranko Gacesa, Stephan P. Keijmel, Ruud P. H. Raijmakers

Publikováno v: Journal of Translational Medicine
Journal of Translational Medicine, 18
Journal of translational medicine
England
Journal of translational medicine, 18(1):448, 1-13. BioMed Central Ltd.
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-13 (2020)
Journal of Translational Medicine, 18, 1

Background Q fever fatigue syndrome (QFS) is characterised by a state of prolonged fatigue that is seen in 20% of acute Q fever infections and has major health-related consequences. The molecular mechanisms underlying QFS are largely unclear. In orde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403944b0ef3e2bb5334a91e52fd18131
https://doi.org/10.21203/rs.3.rs-54097/v1

Cytokine profiles in patients with Q fever fatigue syndrome

Autor: Ruud P. H. Raijmakers, Stephan P. Keijmel, Anne F.M. Jansen, Chantal P. Bleeker-Rovers, Megan E. Roerink, Valerie A. C. M. Koeken, Jos W. M. van der Meer, Leo A. B. Joosten, Mihai G. Netea

Publikováno v: Journal of Infection, 78, 349-357
Journal of Infection, 78, 5, pp. 349-357

Summary Background Q fever fatigue syndrome (QFS) is a state of prolonged fatigue following around 20% of acute Q fever cases. It is thought that chronic inflammation plays a role in its etiology. To test this hypothesis we measured circulating cytok

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ef2b32d0a4c9875e347f9a6d47de9d
https://pubmed.ncbi.nlm.nih.gov/30684502

Postural orthostatic tachycardia is not a useful diagnostic marker for chronic fatigue syndrome

Autor: Johannes W. A. Smit, Iris C. Schmits, Hans Knoop, Arthur M.A. Pistorius, J.W.M. van der Meer, Jacques W.M. Lenders, Megan E. Roerink

Publikováno v: Journal of Internal Medicine, 281, 2, pp. 179-188
Journal of Internal Medicine, 281, 179-188
Journal of internal medicine, 281(2), 179-188. Wiley-Blackwell

Item does not contain fulltext BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) is considered a diagnostic marker for chronic fatigue syndrome (CFS). OBJECTIVES: The aims of this study were to (i) compare POTS prevalence in a CFS cohort w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9230e8e0d792b44df46d15f0d3bcb3ee
https://doi.org/10.1111/joim.12564