Výsledky vyhledávání - "Megan E. Hardie"

The sequence preference of gamma radiation-induced DNA damage as determined by a polymerase stop assay

Publikováno v: International Journal of Radiation Biology. 95:1613-1626

Purpose: The aim of this paper was to investigate the sequence preference of ionizing radiation (IR)-induced DNA damage as assessed by a linear amplification/polymerase stop (LA/PS) assay. The LA/PS assay is able to detect a wide range of IR-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea01159413bd7b65da019fd652d2254e
https://doi.org/10.1080/09553002.2019.1665216

Zobrazit plný text záznamu

Plný text ve formátu HTML

The genome-wide sequence preference of ionising radiation-induced cleavage in human DNA

Autor: Megan E. Hardie, Shweta D. Gautam, Vincent Murray

Publikováno v: Molecular Biology Reports. 46:3731-3745

For ionising radiation (IR)-induced cellular toxicity, DNA cleavage is thought to be a crucial step. In this paper, the genome-wide DNA sequence preference of gamma radiation-induced cleavage was investigated in purified human DNA. We utilised Illumi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5858ff2bf0cd638591fb0970b207f3
https://doi.org/10.1007/s11033-019-04815-6

Zobrazit plný text záznamu

The Sequence Preference of Gamma-Radiation-Induced Damage in End-Labeled DNA after Heat Treatment

Autor: Shweta D. Gautam, Megan E. Hardie, Vincent Murray

Publikováno v: Radiation Research. 189:238-250

In this work, we examined the DNA sequence preference of gamma-radiation-induced DNA damage in purified DNA sequences after heat treatment. DNA was fluorescently end-labeled and gamma-radiation-induced DNA cleavage was examined using capillary electr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ac7bdb5f58de162cf5edc2d27061ce
https://doi.org/10.1667/rr14886.1

Zobrazit plný text záznamu

Comparison of Different Methods to Determine the DNA Sequence Preference of Ionising Radiation-Induced DNA Damage

Autor: Shweta D. Gautam, Megan E. Hardie, Vincent Murray

Publikováno v: Genes
Volume 11
Issue 1

Ionising radiation (IR) is known to induce a wide variety of lesions in DNA. In this review, we compared three different techniques that examined the DNA sequence preference of IR-induced DNA damage at nucleotide resolution. These three techniques we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fb21ea5862e1be6b83e7ed0681a607
https://pubmed.ncbi.nlm.nih.gov/31861886

Zobrazit plný text záznamu

Cisplatin Analogues with an Increased Interaction with DNA: Prospects for Therapy

Autor: Hieronimus W. Kava, Vincent Murray, Megan E. Hardie

Publikováno v: Current Pharmaceutical Design. 22:6645-6664

Cisplatin is widely used as a cancer chemotherapeutic agent and this review covers the mechanism of action of cisplatin, cellular resistance to cisplatin, the genomic location of cisplatin adducts and the properties of DNA-targeted Pt complexes. A pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5874e9adc87beffe68a666185e57c42e
https://doi.org/10.2174/1381612822666160831101529

Zobrazit plný text záznamu

The sequence preference of DNA cleavage by T4 endonuclease VII

Autor: Megan E. Hardie, Vincent Murray

Publikováno v: Biochimie. 146

The enzyme T4 endonuclease VII is a resolvase that acts on branched DNA intermediates during genetic recombination, by cleaving DNA with staggered cuts approximately 3–6 bp apart. In this paper, we investigated the sequence preference of this cleav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c222abd87aca603b7fb24c802f881959
https://pubmed.ncbi.nlm.nih.gov/29129742

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání