Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Megan E. Crowe"'
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145270 (2015)
PURPOSE:RGC-5 cells undergo differentiation into a neuronal phenotype with low concentrations of staurosporine. Although the RGC-5 cell line was initially thought to be of retinal ganglion cell origin, recent evidence suggests that the RGC-5 line cou
Externí odkaz:
https://doaj.org/article/fe3255355c464bf389bad8ffe18d984a
Autor:
Richard T. Libby, Leonard A. Levin, Paul A. Sieving, Alfred Sommer, Robert W. Nickells, Y. Joyce Liao, Larry A. Donoso, Harry A. Quigley, Megan E. Crowe, Richard H. Masland, M Francesca Cordeiro
Publikováno v:
Experimental Eye Research. 157:34-37
Within the field of glaucoma research, neuroprotection is defined as slowing the functional loss in glaucoma by a mechanism independent of lowering of intraocular pressure. There is currently a great potential for research surrounding neuroprotection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ecc06ecaa35c3046ee55a308a9063f
https://doi.org/10.1016/j.exer.2016.12.005
https://doi.org/10.1016/j.exer.2016.12.005
Publikováno v:
Pharmaceutical development and technology. 23(9)
Phosphine-borane complexes are recently developed redox-active drugs that are neuroprotective in models of optic nerve injury and radioprotective in endothelial cells. However, a single dose of these compounds is short-lived, necessitating the develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7264d813cd691e147d226b718be229
https://pubmed.ncbi.nlm.nih.gov/28524719
https://pubmed.ncbi.nlm.nih.gov/28524719
Autor:
Nicholas J. Niemuth, Megan E. Crowe, Leonard A. Levin, Alex F. Thompson, Christopher J. Lieven
Publikováno v:
Neurochemistry international. 99
Phosphine-borane complexes are novel cell-permeable drugs that protect neurons from axonal injury in vitro and in vivo. These drugs activate the extracellular signal-regulated kinases 1/2 (ERK1/2) cell survival pathway and are therefore neuroprotecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f3dd67c5542a4471b73c6632c4abef
https://pubmed.ncbi.nlm.nih.gov/27264910
https://pubmed.ncbi.nlm.nih.gov/27264910
Publikováno v:
Redox Biology
Exposure to radiation can damage endothelial cells in the irradiated area via the production of reactive oxygen species. We synthesized phosphine–borane complexes that reduce disulfide bonds and had previously been shown to interfere with redox-med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276f95c385cfebee3589949816f48b97
https://pubmed.ncbi.nlm.nih.gov/26188467
https://pubmed.ncbi.nlm.nih.gov/26188467
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145270 (2015)
PLoS ONE
PLoS ONE
Purpose RGC-5 cells undergo differentiation into a neuronal phenotype with low concentrations of staurosporine. Although the RGC-5 cell line was initially thought to be of retinal ganglion cell origin, recent evidence suggests that the RGC-5 line cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787e529a5454cde75a5b4fb1b859fc7c
http://europepmc.org/articles/PMC4684327?pdf=render
http://europepmc.org/articles/PMC4684327?pdf=render
PURPOSE. Light-induced oxidative stress is an important risk factor for age-related macular degeneration, but the downstream mediators of photoreceptor and retinal pigment epithelium cell death after photic injury are unknown. Given our previous iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8762e2ee839571c25f3b32f4c6aea0c9
https://europepmc.org/articles/PMC4453105/
https://europepmc.org/articles/PMC4453105/
