Výsledky vyhledávání - "Megan E. Barefoot"

Akademický článek

Impaired CXCL12 signaling contributes to resistance of pancreatic cancer subpopulations to T cell-mediated cytotoxicity

Autor: Yuan-Na Lin, Marcel O. Schmidt, Ghada M. Sharif, Eveline E. Vietsch, Amber J. Kiliti, Megan E. Barefoot, Anna T. Riegel, Anton Wellstein

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

Pancreatic cancer remains largely unresponsive to immune modulatory therapy attributable in part to an immunosuppressive, desmoplastic tumor microenvironment. Here, we analyze mechanisms of cancer cell-autonomous resistance to T cells. We used a 3D c

Externí odkaz: https://doaj.org/article/2d24f4c980be417c897fa5b984546e5d

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Akademický článek

Cardiomyocyte-Specific Circulating Cell-Free Methylated DNA in Esophageal Cancer Patients Treated with Chemoradiation

Autor: Sarah Martinez Roth, Eveline E. Vietsch, Megan E. Barefoot, Marcel O. Schmidt, Matthew D. Park, Archana Ramesh, Michael R. Lindberg, Giuseppe Giaccone, Anna T. Riegel, Ana Barac, Keith Unger, Anton Wellstein

Publikováno v: Gastrointestinal Disorders, Vol 3, Iss 3, Pp 100-112 (2021)

Thoracic high-dose radiation therapy (RT) for cancer has been associated with early and late cardiac toxicity. To assess altered rates of cardiomyocyte cell death due to RT we monitored changes in cardiomyocyte-specific, cell-free methylated DNA (cfD

Externí odkaz: https://doaj.org/article/44f090ede39b42859e5a5e78d9c4ff96

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Akademický článek

Integrative Analysis of DNA Methylation and microRNA Expression Reveals Mechanisms of Racial Heterogeneity in Hepatocellular Carcinoma

Autor: Rency S. Varghese, Megan E. Barefoot, Sidharth Jain, Yifan Chen, Yunxi Zhang, Amber Alley, Alexander H. Kroemer, Mahlet G. Tadesse, Deepak Kumar, Zaki A. Sherif, Habtom W. Ressom

Publikováno v: Frontiers in Genetics, Vol 12 (2021)

Pathologic alterations in epigenetic regulation have long been considered a hallmark of many cancers, including hepatocellular carcinoma (HCC). In a healthy individual, the relationship between DNA methylation and microRNA (miRNA) expression maintain

Externí odkaz: https://doaj.org/article/ab1d0858489a49eeb721da63471b6e3f

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Akademický článek

Detection of Cell Types Contributing to Cancer From Circulating, Cell-Free Methylated DNA

Autor: Megan E. Barefoot, Netanel Loyfer, Amber J. Kiliti, A. Patrick McDeed, Tommy Kaplan, Anton Wellstein

Publikováno v: Frontiers in Genetics, Vol 12 (2021)

Detection of cellular changes in tissue biopsies has been the basis for cancer diagnostics. However, tissue biopsies are invasive and limited by inaccuracies due to sampling locations, restricted sampling frequency, and poor representation of tissue

Externí odkaz: https://doaj.org/article/50170a9771e946198d3f10eb46b65c3a

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Cell-type Deconvolution and Age Estimation Using DNA Methylation Reveals NK Cell Deficiency in the Hepatocellular Carcinoma Microenvironment

Autor: Sidharth S. Jain, Megan E. Barefoot, Rency S. Varghese, Habtom W. Ressom

Publikováno v: 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77fb5de34d68442f9367ec82ce6c525b
https://doi.org/10.1109/bibm55620.2022.9995041

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Cell-free, methylated DNA in blood samples reveals tissue-specific, cellular damage from radiation treatment

Autor: Megan E. Barefoot, Netanel Loyfer, Amber J. Kiliti, Marcel O. Schmidt, Sapir Shabi-Porat, Sidharth Jain, Sarah Martinez Roth, A. Patrick McDeed, Nesreen Shahrour, Elizabeth Ballew, Yun-Tien Lin, Heng-Hong Li, Anne Deslattes Mays, Sonali Rudra, Anna T. Riegel, Keith Unger, Tommy Kaplan, Anton Wellstein

Radiation therapy is an effective cancer treatment although damage to healthy tissues is common. Here we characterize the methylomes of healthy human and mouse tissues to establish sequencing-based, cell-type specific reference DNA methylation atlase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4cf636d536fd4c82418cea0d19b0e95c
https://doi.org/10.1101/2022.04.12.487966