Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Megan D. McCurry"'
Autor:
Arijit A. Adhikari, Megan D. McCurry, A. Sloan Devlin, Snehal N. Chaudhari, Deepti Ramachandran, Alexander S. Banks, Chelsea E. Powell, Wei Li
Publikováno v:
ACS Chem Biol
Bile acids play crucial roles in host physiology by acting as both detergents that aid in digestion and as signaling molecules that bind to host receptors. Gut bacterial bile salt hydrolase (BSH) enzymes perform the gateway reaction leading to the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ec86bd02213ac688357aaf7846ad7e
https://doi.org/10.1021/acschembio.1c00192
https://doi.org/10.1021/acschembio.1c00192
Autor:
Snehal N. Chaudhari, Alexander S. Banks, Chelsea E. Powell, Deepti Ramachandran, Megan D. McCurry, Arijit A. Adhikari, A. S. Devlin
Bile acids play crucial roles in host physiology by acting as both detergents that aid in digestion and as signaling molecules that bind to host receptors. Gut bacterial bile salt hydrolase (BSH) enzymes perform the gateway reaction leading to the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55ec71ed019f4a69fdba3d41a4e44c65
https://doi.org/10.1101/2021.03.15.435552
https://doi.org/10.1101/2021.03.15.435552
Autor:
Yancong Zhang, Curtis Huttenhower, Megan D. McCurry, Gang Wang, Wei Li, Munhyung Bae, Yuan Fang, Sena Bae, A. Sloan Devlin, Eric A. Franzosa, Saiyu Hang, Jun R. Huh, Lina Yao
SUMMARYBile acids act as signaling molecules that regulate immune homeostasis, including the differentiation of CD4+T cells into distinct T cell subsets. The bile acid metabolite isoallolithocholic acid (isoalloLCA) enhances the differentiation of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::567c2c0acb2a265cea700bf987d32b5e
https://doi.org/10.1101/2021.01.08.425963
https://doi.org/10.1101/2021.01.08.425963
Publikováno v:
Nat Chem Biol
Human-associated microorganisms play a vital role in human health, and microbial imbalance has been linked to a wide range of disease states. In this Review, we explore recent efforts to progress from correlative studies that identify microorganisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c97648c52867377afa113d8c5a62cd5
https://pubmed.ncbi.nlm.nih.gov/34552222
https://pubmed.ncbi.nlm.nih.gov/34552222
Autor:
Minghao Zhang, Donggi Paik, Saiyu Hang, A. Sloan Devlin, Wei Li, Jun R. Huh, Yancong Zhang, Sena Bae, Fraydoon Rastinejad, Lina Yao, Eric A. Franzosa, Megan D. McCurry, Yuan Fang, Curtis Huttenhower, Munhyung Bae, Gang Wang
Publikováno v:
Cell Host Microbe
Summary Bile acids act as signaling molecules that regulate immune homeostasis, including the differentiation of CD4+ T cells into distinct T cell subsets. The bile acid metabolite isoallolithocholic acid (isoalloLCA) enhances the differentiation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455db662d5ffb03e422fd66b42303467
https://doi.org/10.1016/j.chom.2021.07.013
https://doi.org/10.1016/j.chom.2021.07.013
Autor:
Yanping Wang, Megan D. McCurry, Heer H. Mehta, Yousif Shamoo, Kiran Kumar Pulukuri, Stephan Rigol, Kathryn Beabout, Akshay A. Shah, Kyriacos C. Nicolaou
Publikováno v:
ACS Infectious Diseases. 3:854-865
The continuing rise of multidrug resistant pathogens has made it clear that in the absence of new antibiotics we are moving toward a “postantibiotic” world, in which even routine infections will become increasingly untreatable. There is a clear n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88b5445a05bb882a6c9c3d4fcaafce4
https://doi.org/10.1021/acsinfecdis.7b00135
https://doi.org/10.1021/acsinfecdis.7b00135
Publikováno v:
Journal of the American Chemical Society. 139:3736-3746
A phase transfer catalyzed asymmetric alkylation of anthrones with cyclic allylic bromides using quinidine- or quinine-derived catalysts is described. Utilizing mild basic conditions and as low as 0.5 mol % catalyst loading, and achieving up to >99:1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304b5965fddaf4fe4acd96ebd59ef75f
https://doi.org/10.1021/jacs.6b12654
https://doi.org/10.1021/jacs.6b12654
Autor:
Lina Yao, Scott B. Ficarro, A. Sloan Devlin, Snehal N. Chaudhari, Deepti Ramachandran, Megan D. McCurry, Sula Ndousse-Fetter, Stephen C. Blacklow, Arijit A. Adhikari, Jarrod A. Marto, Tom C. M. Seegar, Alexander S. Banks
Publikováno v:
Nature chemical biology
Bile salt hydrolase (BSH) enzymes are widely expressed by human gut bacteria and catalyze the gateway reaction leading to secondary bile acid formation. Bile acids regulate key metabolic and immune processes by binding to host receptors. There is an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12b37d114606fd6c99dc7a7ac0093d5
Autor:
Megan D. McCurry, Kiran Kumar Pulukuri, Nicholas Cen, Stephan Rigol, Yousif Shamoo, Kathryn Beabout, Akshay A. Shah, Kyriacos C. Nicolaou, Marek Buchman
Publikováno v:
Journal of the American Chemical Society. 139(44)
An improved and enantioselective total synthesis of antibiotic CJ-16,264 through a practical kinetic resolution and an iodolactonization reaction to form the iodo pyrrolizidinone fragment of the molecule is described. A series of racemic and enantiop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037102a37eab2aa97b61da44d12a97e8
https://pubmed.ncbi.nlm.nih.gov/29064688
https://pubmed.ncbi.nlm.nih.gov/29064688
Autor:
Paul Mann, Amy M. Flattery, Hao Wang, Li Xiao, Xinwei Sher, Megan D. McCurry, Nicholas Murgolo, John A. Howe, Juliana C. Malinverni, Terry Roemer, Artjohn Villafania, Andrew Galgoci, Matthias Mack, Charles Gill, Todd Mayhood, Christopher M. Barbieri
Publikováno v:
Cell chemical biology. 24(5)
Riboswitches are bacterial-specific, broadly conserved, non-coding RNA structural elements that control gene expression of numerous metabolic pathways and transport functions essential for cell growth. As such, riboswitch inhibitors represent a new c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af45a3bf918d0ebd9aced48ac9d78bb
https://pubmed.ncbi.nlm.nih.gov/28434876
https://pubmed.ncbi.nlm.nih.gov/28434876