Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Megan D. Maerz"'
Autor:
Cate Speake, Tania Habib, Katharina Lambert, Christian Hundhausen, Sandra Lord, Matthew J. Dufort, Samuel O. Skinner, Alex Hu, MacKenzie Kinsman, Britta E. Jones, Megan D. Maerz, Megan Tatum, Anne M. Hocking, Gerald T. Nepom, Carla J. Greenbaum, Jane H. Buckner
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Therapeutics that inhibit IL-6 at different points in its signaling pathway are in clinical use, yet whether the immunological effects of these interventions differ based on their molecular target is unknown. We performed short-term interventions in
Externí odkaz:
https://doaj.org/article/0d42c57eea354a0694720ed4803ef101
Autor:
Katharina Lambert, Kirsten E. Diggins, Britta E. Jones, Christian Hundhausen, Megan D. Maerz, Anne M. Hocking, Srinath Sanda, Carla J. Greenbaum, Peter S. Linsley, Karen Cerosaletti, Jane H. Buckner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Elevated levels and enhanced sensing of the pro-inflammatory cytokine interleukin-6 (IL-6) are key features of many autoimmune and inflammatory diseases. To better understand how IL-6 signaling may influence human T cell fate, we investigated the rel
Externí odkaz:
https://doaj.org/article/c773700586e44a7c8cb9899ec2c188f9
Autor:
Meagan E. Chriswell, Adam R. Lefferts, Michael R. Clay, Alex Ren Hsu, Jennifer Seifert, Marie L. Feser, Cliff Rims, Michelle S. Bloom, Elizabeth A. Bemis, Sucai Liu, Megan D. Maerz, Daniel N. Frank, M. Kristen Demoruelle, Kevin D. Deane, Eddie A. James, Jane H. Buckner, William H. Robinson, V. Michael Holers, Kristine A. Kuhn
Publikováno v:
Science Translational Medicine. 14
The mucosal origins hypothesis of rheumatoid arthritis (RA) proposes a central role for mucosal immune responses in the initiation or perpetuation of the systemic autoimmunity that occurs with disease. However, the connection between the mucosa and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0fccfa630d531c39b9143ebc18b089b
https://doi.org/10.1126/scitranslmed.abn5166
https://doi.org/10.1126/scitranslmed.abn5166
Autor:
Britta E. Jones, Megan D. Maerz, Henry T. Bahnson, Ashwin Somasundaram, Lucas H. McCarthy, Cate Speake, Jane H. Buckner
Publikováno v:
J Immunol
The coinhibitory receptor lymphocyte activation gene 3 (LAG-3) is an immune checkpoint molecule that negatively regulates T cell activation, proliferation, and homeostasis. Blockade or deletion of LAG-3 in autoimmune-prone backgrounds or induced-dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05b6cb35e9175270110eba218b848e8
https://europepmc.org/articles/PMC8820445/
https://europepmc.org/articles/PMC8820445/
Publikováno v:
The Journal of Immunology. 206:51.10-51.10
The co-inhibitory receptor lymphocyte activation gene 3 (LAG-3) is an immune checkpoint molecule that negatively regulates T cell activation, proliferation, and homeostasis. Blockade or deletion of LAG-3 in autoimmune-prone backgrounds or induced-dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba7fe4f6922818691761021812149ae8
https://doi.org/10.4049/jimmunol.206.supp.51.10
https://doi.org/10.4049/jimmunol.206.supp.51.10
Publikováno v:
Current opinion in immunology. 55
IL-6 is implicated in the development and progression of autoimmune diseases in part by influencing CD4 T cell lineage and regulation. Elevated IL-6 levels drive inflammation in a wide range of autoimmune diseases, some of which are also characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665380bc9d1c1779cd939d7ade6cbeef
https://pubmed.ncbi.nlm.nih.gov/30248523
https://pubmed.ncbi.nlm.nih.gov/30248523