Zobrazeno 1 - 3 of 3 pro vyhledávání: '"Megan D. Lee"'
1
The Use of Flow Cytometry to Assess the State of Chromatin in T Cells
Autor: Kellie N. Bingham, Megan D. Lee, Jason S. Rawlings
Publikováno v: Journal of Visualized Experiments : JoVE
During a proper immune response, quiescent T cells become activated upon antigen presentation to their antigen-specific T cell receptor. This leads to clonal proliferation of only those T cells that bear a receptor that recognizes the antigen. Chroma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5ae38770076c4f9608e07d1ec7bb97
http://europepmc.org/articles/PMC4694037
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2
Calcium mobilization is both required and sufficient for initiating chromatin decondensation during activation of peripheral T-cells
Autor: Jason S. Rawlings, Taylor Y. Mitchell, Megan D. Lee, Jenna L. Meredith, Kellie N. Bingham
Antigen engagement of the T-cell receptor (TCR) induces a rapid and dramatic decondensation of chromatin that is necessary for T-cell activation. This decondensation makes T-cells competent to respond to interleukin-2 providing a mechanism to ensure
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631413ccc4a9249dc17e036ccd4e6f40
https://europepmc.org/articles/PMC4254631/
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