Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Megan D. Hopkins"'
Publikováno v:
ACS Omega, Vol 6, Iss 28, Pp 18333-18343 (2021)
Externí odkaz:
https://doaj.org/article/1c20545866344da5a8142197e566e823
Autor:
Frances M. Potjewyd, Joel K. Annor‐Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L. Conlon, Kevin J. Frankowski, Shiva K. R. Guduru, Brian P. Hardy, Megan D. Hopkins, Chizuru Kinoshita, Dmitri B. Kireev, Emily R. Mason, Charles T. Moerk, Felix Nwogbo, Kenneth H. Pearce Jr., Timothy I. Richardson, David A. Rogers, Disha M. Soni, Michael Stashko, Xiaodong Wang, Carrow Wells, Timothy M. Willson, Stephen V. Frye, Jessica E. Young, Alison D. Axtman
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction A chemogenomic set of small molecules with annotated activities and implicated roles in Alzheimer's disease (AD) called the AD Informer Set was recently developed and made available to the AD research community: https://treatad.
Externí odkaz:
https://doaj.org/article/b33c64d9d5fa4d89ad4554a76c6b0930
Autor:
Frances M. Potjewyd, Joel K. Annor‐Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L. Conlon, Kevin J. Frankowski, Shiva K. R. Guduru, Brian P. Hardy, Megan D. Hopkins, Chizuru Kinoshita, Dmitri B. Kireev, Emily R. Mason, Charles T. Moerk, Felix Nwogbo, Kenneth H. Pearce, Timothy I. Richardson, David A. Rogers, Disha M. Soni, Michael Stashko, Xiaodong Wang, Carrow Wells, Timothy M. Willson, Stephen V. Frye, Jessica E. Young, Alison D. Axtman
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction The portfolio of novel targets to treat Alzheimer's disease (AD) has been enriched by the Accelerating Medicines Partnership Program for Alzheimer's Disease (AMP AD) program. Methods Publicly available resources, such as literat
Externí odkaz:
https://doaj.org/article/e2d6a7a95cd548b0ab470f7102528da7
Autor:
David A. Rogers, Megan D. Hopkins, Nitya Rajagopal, Dhruv Varshney, Haley A. Howard, Gabriel LeBlanc, Angus A. Lamar
Publikováno v:
ACS Omega, Vol 5, Iss 13, Pp 7693-7704 (2020)
Externí odkaz:
https://doaj.org/article/4034b7b04c574f7aa18bc3020703b26a
Autor:
David A. Rogers, Roxanne G. Brown, Zachary C. Brandeburg, Eric Y. Ko, Megan D. Hopkins, Gabriel LeBlanc, Angus A. Lamar
Publikováno v:
ACS Omega, Vol 3, Iss 10, Pp 12868-12877 (2018)
Externí odkaz:
https://doaj.org/article/11f1d6b19f1a40789f83d151f243f71f
Publikováno v:
Molecules, Vol 23, Iss 8, p 1838 (2018)
Alternative synthetic methodology for the direct installation of sulfonamide functionality is a highly desirable goal within the domain of drug discovery and development. The formation of synthetically valuable N-sulfonyl imines from a range of aldeh
Externí odkaz:
https://doaj.org/article/ac9fe94bd41f49a7ad795ff666dbc84a
Autor:
Megan D. Hopkins, Ryan C. Witt, Ann Marie E. Flusche, John E. Philo, Garett L. Ozmer, Gordon H. Purser, Robert J. Sheaff, Angus A. Lamar
Publikováno v:
Organic & Biomolecular Chemistry. 20:6680-6693
New methods for installation of a N-sulfonyl unit into PH scaffolds via a N-centered radical approach have been developed. Synthesized PH sulfonamides have been screened against mammalian cell lines and bacterial strains for biological activity.
Publikováno v:
ACS Omega, Vol 6, Iss 28, Pp 18333-18343 (2021)
ACS Omega
ACS Omega
Traditional long exposure (24-72 h) cell viability assays for identification of potential drug compounds can fail to identify compounds that are: (a) biologically active but not toxic and (b) inactive without the addition of a synergistic additive. H
Autor:
Robert J. Sheaff, Garett L. Ozmer, Claire E Keating, David A. Rogers, Angus A. Lamar, Presley L Petcoff, Megan D. Hopkins, Zachary C. Brandeburg, Ryan C Witt
Publikováno v:
Organic & Biomolecular Chemistry. 19:1133-1144
The development of new approaches toward chemo- and regioselective functionalization of polycyclic aromatic hydrocarbon (PAH) scaffolds will provide opportunities for the synthesis of novel biologically active small molecules that exploit the high de
Autor:
Haley A Howard, Dhruv Varshney, Nitya Rajagopal, David A. Rogers, Angus A. Lamar, Megan D. Hopkins, Gabriel LeBlanc
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 13, Pp 7693-7704 (2020)
ACS Omega, Vol 5, Iss 13, Pp 7693-7704 (2020)
Seven FDA-certified food dyes have been investigated as organocatalysts. As a result, Fast Green FCF and Brilliant Blue FCF have been discovered as catalysts for the chlorination of a wide range of arenes and heteroarenes in moderate to excellent yie