Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Megan D. Hoban"'
Autor:
Caroline Y. Kuo, Joseph D. Long, Beatriz Campo-Fernandez, Satiro de Oliveira, Aaron R. Cooper, Zulema Romero, Megan D. Hoban, Alok V. Joglekar, Georgia R. Lill, Michael L. Kaufman, Sorel Fitz-Gibbon, Xiaoyan Wang, Roger P. Hollis, Donald B. Kohn
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2606-2616 (2018)
X-linked hyper-immunoglobulin M (hyper-IgM) syndrome (XHIM) is a primary immunodeficiency due to mutations in CD40 ligand that affect immunoglobulin class-switch recombination and somatic hypermutation. The disease is amenable to gene therapy using r
Externí odkaz:
https://doaj.org/article/a9f7ea463fcd4ac88ca63a2c49143223
Autor:
Alok V. Joglekar, Sorel Fitz-Gibbon, Zulema Romero, Caroline Y. Kuo, Georgia R. Lill, Joseph Long, Aaron R. Cooper, Beatriz Campo-Fernandez, Satiro N. De Oliveira, Xiaoyan Wang, Roger P. Hollis, Megan D. Hoban, Donald B. Kohn, Michael L. Kaufman
Publikováno v:
Cell reports, vol 23, iss 9
Cell Reports, Vol 23, Iss 9, Pp 2606-2616 (2018)
Cell Reports, Vol 23, Iss 9, Pp 2606-2616 (2018)
X-linked hyper-immunoglobulin M (hyper-IgM) syndrome (XHIM) is a primary immunodeficiency due to mutations in CD40 ligand that affect immunoglobulin class-switch recombination and somatic hypermutation. The disease is amenable to gene therapy using r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec0b2de7307a0060619ed6080cfd1eb
https://doi.org/10.1016/j.celrep.2018.04.103
https://doi.org/10.1016/j.celrep.2018.04.103
Autor:
Eric Miyahira, Donald B. Kohn, Danielle N. Clark, Joseph Long, Caroline Y. Kuo, Katelyn E. Masiuk, Zulema Romero, Yerbol Z. Kurmangaliyev, Beatriz Campo-Fernandez, Julie M. Sanchez, Ruixue Zhang, Suzanne Said, Anastasia Lomova, Alexandra Miggelbrink, Megan D. Hoban, Xiaoyan Wang, Roger P. Hollis, Devin Brown, Miriam Velez
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy, vol 27, iss 8
Mol Ther
Mol Ther
Site-specific correction of a point mutation causing a monogenic disease in autologous hematopoietic stem and progenitor cells (HSPCs) can be used as a treatment of inherited disorders of the blood cells. Sickle cell disease (SCD) is an ideal model t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562e02d2604c4665940c8b4a73f1699e
https://escholarship.org/uc/item/6802h9n8
https://escholarship.org/uc/item/6802h9n8
Autor:
Kevin A. Goncalves, Megan D. Hoban, Jennifer L. Proctor, Sharon L. Hyzy, Hillary L. Adams, Jason P. Gardner, Anthony E. Boitano, Michael P. Cooke
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7092642cd82398c34f70f9bf0bbbb5ef
https://doi.org/10.2139/ssrn.3151988
https://doi.org/10.2139/ssrn.3151988
Autor:
Zulema Romero, Edward J. Rebar, Andrew Wilber, Roger P. Hollis, Matthew C. Mendel, Lei Zhang, Fabrizia Urbinati, David Gray, Alok V. Joglekar, Michael L. Kaufman, Allen Zhu, Shantha Senadheera, Michael C. Holmes, Aaron R. Cooper, Philip D. Gregory, David Paschon, Michelle Ho, Megan D. Hoban, Dianne Lumaquin, Donald B. Kohn, Gregory J. Cost, Andreas Reik, Georgia R. Lill, Xiaoyan Wang, Pei-Qi Liu
Publikováno v:
Blood. 125:2597-2604
Sickle cell disease (SCD) is characterized by a single point mutation in the seventh codon of the β-globin gene. Site-specific correction of the sickle mutation in hematopoietic stem cells would allow for permanent production of normal red blood cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7456de13001543a5d1c22eb7deeb9f43
https://doi.org/10.1182/blood-2014-12-615948
https://doi.org/10.1182/blood-2014-12-615948
Autor:
Xiaoyan Wang, Beatriz Campo-Fernandez, Megan D. Hoban, Michael L. Kaufman, Caroline Y. Kuo, Roger P. Hollis, Dianne Lumaquin, Donald B. Kohn, Zulema Romero, Joseph Long, Aaron R. Cooper
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 26(2)
The use of engineered nucleases combined with a homologous DNA donor template can result in targeted gene correction of the sickle cell disease mutation in hematopoietic stem and progenitor cells. However, because of the high homology between the adj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf99bd8042b58866ad392a7337b2d1e
https://pubmed.ncbi.nlm.nih.gov/29221806
https://pubmed.ncbi.nlm.nih.gov/29221806
Publikováno v:
Human gene therapy, vol 25, iss 7
Integrase-defective lentiviral vectors (IDLVs) have been of limited success in the delivery of zinc finger nucleases (ZFNs) to human cells, due to low expression. A reason for reduced gene expression has been proposed to involve the epigenetic silenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfa85257f68079840e1260eea3d9766
https://doi.org/10.1089/hum.2013.211
https://doi.org/10.1089/hum.2013.211
Autor:
Katia S. George, Anthony E. Boitano, Jennifer L. Proctor, Megan D. Hoban, Kevin A. Goncalves, Sharon L. Hyzy, Michael P. Cooke
Publikováno v:
Biology of Blood and Marrow Transplantation. 24:S115-S116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28ece91aa359cebe93e6b98f1208c79c
https://doi.org/10.1016/j.bbmt.2017.12.031
https://doi.org/10.1016/j.bbmt.2017.12.031
Autor:
Brad R. Pearse, Michael P. Cooke, Rahul Palchaudhuri, Sharon L. Hyzy, Kevin A. Goncalves, Jennifer L. Proctor, Hillary L. Adams, Megan D. Hoban, Anthony E. Boitano, Rajiv Panwar, Sean McDonough, Adam J. Hartigan, Molly A McShea
Publikováno v:
Biology of Blood and Marrow Transplantation. 24:S47-S48
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d0210a88de589cf9e5aca4c9e68ad8e
https://doi.org/10.1016/j.bbmt.2017.12.598
https://doi.org/10.1016/j.bbmt.2017.12.598
Autor:
Daniel E. Bauer, Megan D. Hoban
Gene editing enables the site-specific modification of the genome. These technologies have rapidly advanced such that they have entered common use in experimental hematology to investigate genetic function. In addition, genome editing is becoming inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6574d6a8b9130d4f6584f55f226f9cd5
https://europepmc.org/articles/PMC4882802/
https://europepmc.org/articles/PMC4882802/