Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Megan D, Lenardon"'
Autor:
Sebastian Schaefer, Raghav Vij, Jakob L. Sprague, Sophie Austermeier, Hue Dinh, Peter R. Judzewitsch, Sven Müller-Loennies, Taynara Lopes Silva, Eric Seemann, Britta Qualmann, Christian Hertweck, Kirstin Scherlach, Thomas Gutsmann, Amy K. Cain, Nathaniel Corrigan, Mark S. Gresnigt, Cyrille Boyer, Megan D. Lenardon, Sascha Brunke
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract More than two million people worldwide are affected by life-threatening, invasive fungal infections annually. Candida species are the most common cause of nosocomial, invasive fungal infections and are associated with mortality rates above 4
Externí odkaz:
https://doaj.org/article/4855006eb2384c85b16fca8c8d5c88bf
Publikováno v:
The Cell Surface, Vol 6, Iss , Pp 100047- (2020)
Despite the importance of fungal cell walls as the principle determinant of fungal morphology and the defining element determining fungal interactions with other cells, few scalar models have been developed that reconcile chemical and microscopic att
Externí odkaz:
https://doaj.org/article/80826c8b6e6640ed99a91343fbc24b1b
Autor:
Louise Walker, Prashant Sood, Megan D. Lenardon, Gillian Milne, Jon Olson, Gerard Jensen, Julie Wolf, Arturo Casadevall, Jill Adler-Moore, Neil A. R. Gow
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
ABSTRACT The fungal cell wall is a critically important structure that represents a permeability barrier and protective shield. We probed Candida albicans and Cryptococcus neoformans with liposomes containing amphotericin B (AmBisome), with or withou
Externí odkaz:
https://doaj.org/article/1d4cb09fdbb94153b48f0ccb07f36441
Autor:
Sarah L Sherrington, Eleanor Sorsby, Nabeel Mahtey, Pizga Kumwenda, Megan D Lenardon, Ian Brown, Elizabeth R Ballou, Donna M MacCallum, Rebecca A Hall
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006403 (2017)
Candida albicans is able to proliferate in environments that vary dramatically in ambient pH, a trait required for colonising niches such as the stomach, vaginal mucosal and the GI tract. Here we show that growth in acidic environments involves cell
Externí odkaz:
https://doaj.org/article/145beb5482ce4248b3639c5171e302e9
Autor:
Neil A R, Gow, Megan D, Lenardon
Publikováno v:
Nature reviews. Microbiology.
The fungal cell wall is essential for growth and survival, and is a key target for antifungal drugs and the immune system. The cell wall must be robust but flexible, protective and shielding yet porous to nutrients and membrane vesicles and receptive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ce7941bc50babef96fd08a08341cdb8
https://pubmed.ncbi.nlm.nih.gov/36266346
https://pubmed.ncbi.nlm.nih.gov/36266346
Autor:
Delma S Childers, Ingrida Raziunaite, Gabriela Mol Avelar, Joanna Mackie, Susan Budge, David Stead, Neil A R Gow, Megan D Lenardon, Elizabeth R Ballou, Donna M MacCallum, Alistair J P Brown
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005566 (2016)
Efficient carbon assimilation is critical for microbial growth and pathogenesis. The environmental yeast Saccharomyces cerevisiae is "Crabtree positive", displaying a rapid metabolic switch from the assimilation of alternative carbon sources to sugar
Externí odkaz:
https://doaj.org/article/480c42f57b65432d93a7ba882d68edff
Autor:
Liviana Ricci, Joanna Mackie, Gillian E Donachie, Ambre Chapuis, Kristýna Mezerová, Megan D Lenardon, Alistair J P Brown, Sylvia H Duncan, Alan W Walker
The human gut microbiota protects the host from invading pathogens and the overgrowth of indigenous opportunistic species via mechanisms such as competition for nutrients and by production of antimicrobial compounds. Here, we investigated the antagon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd239ad793b5ef0a620989c5b6fdc787
https://doi.org/10.1101/2021.12.21.473717
https://doi.org/10.1101/2021.12.21.473717
Autor:
Neil A. R. Gow, Filomena Nogueira, Alessandra da Silva Dantas, Megan D. Lenardon, Louise A. Walker, Keunsook K. Lee, Alexandra C. Brand, Matt Edmondson
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Echinocandins such as caspofungin are frontline antifungal drugs that compromise β-1,3 glucan synthesis in the cell wall. Recent reports have shown that fungal cells can resist killing by caspofungin by upregulation of chitin synthesis, thereby sust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66cfe37285c62b839c25760eb52391f3
https://doi.org/10.1242/jcs.258889
https://doi.org/10.1242/jcs.258889
Autor:
Jeanette Wagener, R K Subbarao Malireddi, Megan D Lenardon, Martin Köberle, Simon Vautier, Donna M MacCallum, Tilo Biedermann, Martin Schaller, Mihai G Netea, Thirumala-Devi Kanneganti, Gordon D Brown, Alistair J P Brown, Neil A R Gow
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004050 (2014)
Chitin is an essential structural polysaccharide of fungal pathogens and parasites, but its role in human immune responses remains largely unknown. It is the second most abundant polysaccharide in nature after cellulose and its derivatives today are
Externí odkaz:
https://doaj.org/article/896f903ec14a425089cb1524216b009c
Autor:
Sebastian Schaefer, Megan D. Lenardon, Bernhard Hube, Sascha Brunke, Cyrille Boyer, Thi Thu Phuong Pham, Kenward Jung
Publikováno v:
ACS applied materialsinterfaces. 13(23)
Life-threatening invasive fungal infections represent an urgent threat to human health worldwide. The limited set of antifungal drugs has critical constraints such as resistance development and/or adverse side effects. One approach to overcome these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9232bc0abdde9b60865de7ea69a37f
https://pubmed.ncbi.nlm.nih.gov/34060800
https://pubmed.ncbi.nlm.nih.gov/34060800