Výsledky vyhledávání - "Megan Crumbaker"

Akademický článek

Circulating Tumour DNA Biomarkers Associated with Outcomes in Metastatic Prostate Cancer Treated with Lutetium-177-PSMA-617

Autor: Megan Crumbaker, Leonard D. Goldstein, David H. Murray, Jiang Tao, Sarennya Pathmanandavel, Nicky Boulter, Lalith Ratnayake, Anthony M. Joshua, Sarah Kummerfeld, Louise Emmett

Publikováno v: European Urology Open Science, Vol 57, Iss , Pp 30-36 (2023)

Background: Lutetium-177-prostate-specific membrane antigen- 617 (Lu-PSMA) is an effective therapy for metastatic castration-resistant prostate cancer (mCRPC). However, treatment responses are heterogeneous despite stringent positron emission tomogra

Externí odkaz: https://doaj.org/article/917bf043cf3d4ac389625c16e394999a

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Akademický článek

The cell-free DNA methylome captures distinctions between localized and metastatic prostate tumors

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Metastatic prostate cancer can be difficult to biopsy and characterise. Here, the authors use cell-free DNA methylation analysis to illustrate changes in hypermethylation in metastatic disease.

Externí odkaz: https://doaj.org/article/7b26255c7880443b834672c94a98b048

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Akademický článek

Patient outcomes following a response biomarker-guided approach to treatment using 177Lu-PSMA-I&T in men with metastatic castrate-resistant prostate cancer (Re-SPECT)

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 15 (2023)

Background: 177 LuPSMA is an effective treatment in metastatic castrate-resistant prostate cancer with trials adopting a standardised dose interval. Adjusting treatment intervals utilising early response biomarkers may improve patient outcomes. Objec

Externí odkaz: https://doaj.org/article/ac05d1fb3eb0484885744861a7656b88

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Akademický článek

Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer

Publikováno v: BMC Medicine, Vol 20, Iss 1, Pp 1-14 (2022)

Abstract Background Both changes in circulating lipids represented by a validated poor prognostic 3-lipid signature (3LS) and somatic tumour genetic aberrations are individually associated with worse clinical outcomes in men with metastatic castratio

Externí odkaz: https://doaj.org/article/0c49ff062a1c4a14adec64ab46d60c0a

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Akademický článek

GUIDE: a randomised non-comparative phase II trial of biomarker-driven intermittent docetaxel standard-of-care docetaxel in metastatic castration-resistant prostate cancer (clinical trial protocol)

Autor: Ciara Conduit, Blossom Mak, Wenjia Qu, Juliana Di Lulio, Ronan Burder, Matthias Bressel, Thomas Cusick, Haryana M. Dhillon, Richard De Abreu Lourenço, Craig Underhill, Javier Torres, Megan Crumbaker, Florian Honeyball, Anthony Linton, Ray Allen, Ian D. Davis, Susan J. Clark, Lisa G. Horvath, Kate L. Mahon

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 14 (2022)

Objective: To determine the efficacy and safety of intermittent docetaxel chemotherapy guided by circulating methylated glutathione S-transferase Pi-1 ( mGSTP1 ) in men with metastatic castration-resistant prostate cancer (CRPC). Patients and Methods

Externí odkaz: https://doaj.org/article/a39320096f8748238086520bc5368c74

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Akademický článek

Expansion of Lymphocytes from Prostatic Adenocarcinoma and Adjacent Nonmalignant Tissue

Autor: Linh T. Nguyen, Charlotte S. Lo, Michael Fyrsta, Jessica Nie, Jennifer Y. Yam, Pei-Hua Yen, Michael X. Le, Karen Hersey, Miran Kenk, Megan Crumbaker, Neil Fleshner, Girish Kulkarni, Robert Hamilton, Michael Jewett, Antonio Finelli, Andrew Evans, Joan Sweet, Pamela S. Ohashi, Anthony M. Joshua

Publikováno v: Prostate Cancer, Vol 2022 (2022)

Background. The evaluation of tumour-infiltrating lymphocytes (TILs) in solid malignancies has yielded insights into immune regulation within the tumour microenvironment and has also led to the development and optimisation of adoptive T cell therapie

Externí odkaz: https://doaj.org/article/c4ca7626d4f24677b4e9214d25a6de45

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Akademický článek

Overcoming enzalutamide resistance in metastatic prostate cancer by targeting sphingosine kinase

Publikováno v: EBioMedicine, Vol 72, Iss , Pp 103625- (2021)

Background: Intrinsic resistance to androgen receptor signalling inhibitors (ARSI) occurs in 20–30% of men with metastatic castration-resistant prostate cancer (mCRPC). Ceramide metabolism may have a role in ARSI resistance. Our study's aim is to i

Externí odkaz: https://doaj.org/article/9cf94dae05774bb884af7691d010665c

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