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pro vyhledávání: '"Megan Cavanaugh"'
Autor:
Serge P. Nana-Sinkam, Yun Wu, Daniel Gallego-Perez, Kwang Joo Kwak, Megan Cavanaugh Terp, L. James Lee
Publikováno v:
Small. 9:2358-2367
Many delivery methods have been developed to improve the therapeutic efficacy and facilitate the clinical translation of nucleic acid-based therapeutics. A facile surface-mediated nucleic acid delivery by lipoplexes is prepared in a microwell array,
Autor:
Finn Bauer, Robert W. Brueggemeier, Robert J. Lee, Megan Cavanaugh Terp, Yasuro Sugimoto, Bo Yu, L. James Lee
Publikováno v:
International Journal of Pharmaceutics. 430:328-334
DOTAP, as a racemic mixture, is a cationic lipid and a widely used transfection reagent. In this study, the effect of DOTAP’s stereochemical structure on transfection efficiency was evaluated in vitro. Racemic and enantiomerically pure DOTAP were u
Autor:
Megan Cavanaugh, Pouyan E. Boukany, Nan-Rong Chiou, Jingjiao Guan, Weibin Zha, Orin Hemminger, L. James Lee
Publikováno v:
Advanced Materials. 22:3997-4001
One-dimensional nanostructures such as nanochannels (and nanotubes) are characterized by extremely small transverse size and resultant high degree of spatial confinement that endow them a unique set of properties. When patterned laterally, these nano
Publikováno v:
Diseases of the Colon & Rectum. 45:349-353
The purpose of this study was to use the Fecal Incontinence Severity Index to assess fecal incontinence after fistulotomy and to correlate the Fecal Incontinence Severity Index score with quality-of-life measures.A retrospective chart review was perf
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 30(10)
Nucleic acid based therapeutics has been widely explored to treat genetic and acquired diseases. However, the clinical translation of nucleic acid based therapies has been challenged by low delivery efficiency, off-target effects, poor cellular uptak
Autor:
Michael Adornato, Ailish Briglin, Kelly Jewett, Megan Cavanaugh, Dean A. Tyrell, Todd Christian, Sue Ann Miller, Julie Tignor, Cheryl L. Michaelson, Frank Price, Tama Monoson
Publikováno v:
Developmental Dynamics. 216:398-410
A profile of proliferative growth assessed with tritium autoradiograms from White Leghorn embryo stages Hamburger–Hamilton 6–21 labeled in ovo presents evidence of hinged folding driven by localized differential cell proliferation in endoderm. Th
Autor:
Terp, Megan Cavanaugh
The field of nucleic acid based therapeutics offers treatments for diseases at the most basic level of cellular biochemistry and its potential is boundless. Oligonucleotide therapeutics is also an invaluable tool in studying cellular processes and th
Externí odkaz:
http://rave.ohiolink.edu/etdc/view?acc_num=osu1338301430
Autor:
Kalpana Ghoshal, Bo Yu, Feng Wang, Shu-Hao Hsu, Megan Cavanaugh Terp, Samson T. Jacob, Lesheng Teng, Chenguang Zhou, Yun Wu, Xinmei Wang, Ly James Lee, Weiming Xue, Robert J. Lee, Yicheng Mao
Publikováno v:
Biomaterials. 33(25)
Clinical application of small interfering RNA (siRNA) requires safe and efficient delivery in vivo. Here, we report the design and synthesis of lipid nanoparticles (LNPs) for siRNA delivery based on cationic lipids with multiple tertiary amines and h
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Akademický článek
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