Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Megan Carver"'
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
RNA interference (RNAi) has potential to become a major tool for integrated management of insect pests of agricultural crops based on sequence-specificity and low doses of rapidly biodegradable dsRNA. Deploying ‘environmental RNAi’ for control of
Externí odkaz:
https://doaj.org/article/1618f0545f2a4f2cb5980ba290e42a1e
Publikováno v:
Biochimica et biophysica acta. General subjects. 1862(4)
Background While the most stable G-quadruplex formed in the human PDGFR-β promoter nuclease hypersensitive element (NHE) is the 5′-mid G-quadruplex, the 3′-end sequence that contains a 3′-GGA run forms a less stable G-quadruplex. Recently, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1028c4806fcd0af8d2c11c8ac0056e
https://pubmed.ncbi.nlm.nih.gov/29288770
https://pubmed.ncbi.nlm.nih.gov/29288770
Autor:
Salil Kalarn, Guanhui Wu, Buket Onel, Daria Timonina, Megan Carver, Marti Larriva, Danzhou Yang
Publikováno v:
Journal of the American Chemical Society. 138(8)
The abnormal over-expression of the BCL2 gene is associated with many human tumors. We found a new 28-mer G-quadruplex-forming sequence, P1G4, immediately upstream of the human BCL2 gene P1 promoter. The P1G4 is shown to be a transcription repressor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33cecc983d68db77a790ed9737d7959
https://pubmed.ncbi.nlm.nih.gov/26841249
https://pubmed.ncbi.nlm.nih.gov/26841249
Publikováno v:
Journal of the American Chemical Society
The human BCL-2 gene contains a 39-bp GC-rich region upstream of the P1 promoter that has been shown to be critically involved in the regulation of BCL-2 gene expression. Inhibition of BCL-2 expression can decrease cellular proliferation and enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74cdb9c3f39fc7f2308f30554e77c319
https://doi.org/10.1021/ja4118945
https://doi.org/10.1021/ja4118945
Publikováno v:
Nucleic Acids Research
Vascular endothelial growth factor (VEGF) proximal promoter region contains a poly G/C-rich element that is essential for basal and inducible VEGF expression. The guanine-rich strand on this tract has been shown to form the DNA G-quadruplex structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ea02d315213e532470dc9ec271e0f1
https://doi.org/10.1093/nar/gkt784
https://doi.org/10.1093/nar/gkt784
Publikováno v:
Protein Science. 18:1326-1331
In probing the mechanism of inhibition of hypoxia inducible factor (HIF-1) by campothecins, we investigated the ability of human topoisomerase I to bind and cleave HIF-1 response element (HRE), which contains the known camptothecin-mediated topoisome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e091cb526ff12dc80fc641eb201faeb6
https://doi.org/10.1002/pro.138
https://doi.org/10.1002/pro.138
Publikováno v:
Journal of Structural Biology. 159:111-121
Human topoisomerase I (topo I) is an essential cellular enzyme that relaxes DNA supercoiling. The 6.3 kDa C-terminal domain of topo I contains the active site tyrosine (Tyr723) but lacks enzymatic activity by itself. Activity can be fully reconstitut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26a86252689a3159ae3720d67fb35e9
https://doi.org/10.1016/j.jsb.2007.03.001
https://doi.org/10.1016/j.jsb.2007.03.001
Publikováno v:
Cancer Research. 77:5230-5230
Aberrant expression of PDGFR-β promotes multiple hallmarks of cancer, and its transcriptional regulation provides an attractive means to inhibit the PDGFR-β signaling pathway. The nuclease hypersensitive element (NHE) region of the human PDGFR-β c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d98854864c61e675b28beb0849fc0c88
https://doi.org/10.1158/1538-7445.am2017-5230
https://doi.org/10.1158/1538-7445.am2017-5230
Autor:
Jixun Dai, Roger A. Jones, Danzhou Yang, Attila Ambrus, Megan Carver, Ding Chen, Thomas S. Dexheimer
Publikováno v:
Journal of the American Chemical Society. 128:1096-1098
We report the first G-quadruplex structure formed in the promoter region of the human bcl-2. Bcl-2 is a potent oncoprotein that functions as an inhibitor of cell apoptosis and has been found to be aberrantly overexpressed in a wide range of human tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108d041e140dbc717d65d4b656def22d
https://doi.org/10.1021/ja055636a
https://doi.org/10.1021/ja055636a
Autor:
Prashansa Agrawal, Robert H. Brown, Buket Onel, Laurence H. Hurley, Megan Carver, Danzhou Yang
Publikováno v:
Cancer Research. 76:3089-3089
Abnormal expression of PDGFR-β protein contributes to several malignancies. PDGFR-β has become increasingly attractive therapeutic target in the treatments of certain cancers. A G-quadruplex-forming nuclease hypersensitive element (NHE) in the huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecc0a4cd7ca112e013ce1d50d1f1f7c5
https://doi.org/10.1158/1538-7445.am2016-3089
https://doi.org/10.1158/1538-7445.am2016-3089