Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Megan C. Sherwood"'
Autor:
Julie R. McMullen, George Thomas, Sarah Longnus, Tetsuo Shioi, Seigo Izumo, Kathleen A. Martin, Oleg Tarnavski, John Blenis, Li Zhang, Mario Pende, Megan C. Sherwood, Adam L. Dorfman
Publikováno v:
Mol Cell Biol
Ribosomal S6 kinases (S6Ks) have been depicted as critical effectors downstream of growth factor pathways, which play an important role in the regulation of protein synthesis by phosphorylating the ribosomal protein, S6. The goal of this study was to
Autor:
Warunee Dansithong, Cordula M Wolf, Partha Sarkar, Sharan Paul, Andy Chiang, Ian Holt, Glenn E Morris, Dorothy Branco, Megan C Sherwood, Lucio Comai, Charles I Berul, Sita Reddy
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3968 (2008)
The genetic basis of myotonic dystrophy type I (DM1) is the expansion of a CTG tract located in the 3' untranslated region of DMPK. Expression of mutant RNAs encoding expanded CUG repeats plays a central role in the development of cardiac disease in
Externí odkaz:
https://doaj.org/article/23a0a9d0035541b38e262cb6854027ff
Autor:
Megan C. Sherwood, Amir Maghsoudi, Supreet P Marathe, Yishay Orr, Geoffrey McCowage, Mani Ram Krishna
Publikováno v:
The Annals of thoracic surgery. 107(3)
Primary cardiac tumors in children are uncommon and rarely demand surgical intervention. We report a malignant tumor arising from the aortic root in a 5-year-old boy presenting with left ventricular outflow tract obstruction and tumor embolism, its s
Publikováno v:
Journal of Paediatrics and Child Health. 49:795-799
Children with corrected common congenital heart lesions are often withheld from regular exercise by their parents. While there are some modest risks with exercise, they should be seen in perspective, and the life-long benefits of regular exercise on
Publikováno v:
The Journal of thoracic and cardiovascular surgery. 152(2)
Publikováno v:
Journal of Paediatrics and Child Health. 48:E156-E160
Sudden cardiac death (SCD) is an uncommon but devastating potential consequence of participation in competitive sport. It is seen in adolescent and young adult athletes. The most common cause of this, hypertrophic cardiomyopathy (HCM), is a genetic d
Autor:
Jonathan R. Egan, Megan C. Sherwood, David S. Winlaw, Carol G. Au, Kathryn N. North, Tanya L. Butler
Publikováno v:
International Journal of Experimental Pathology. 92:57-65
Cardiomyopathy contributes to morbidity and mortality in Duchenne muscular dystrophy (DMD), a progressive muscle-wasting disorder. A major feature of the hearts of DMD patients and the mdx mouse model of the disease is cardiac fibrosis. Connective ti
Autor:
Charles I. Berul, Anne Pizard, Megan C. Sherwood, Libin Wang, Vincent See, Patrick G. Burgon, Cordula M. Wolf, Jonathan G. Seidman, Hiroko Wakimoto, Dorothy M. Branco, Ferhaan Ahmad, Ronny Alcalai, Christine E. Seidman, David A. Conner, Glenn I. Fishman, Colin L. Stewart
Publikováno v:
Journal of Molecular and Cellular Cardiology. 44:293-303
Mutations in the lamin A/C (LMNA) gene, which encodes nuclear membrane proteins, cause a variety of human conditions including dilated cardiomyopathy (DCM) with associated cardiac conduction system disease. To investigate mechanisms responsible for e
Publikováno v:
Paediatric Respiratory Reviews. 8:313-322
The dynamic interaction between the heart and lungs leads to a degree of respiratory co-morbidity including both restrictive and obstructive airway abnormalities, which may be overlooked in children with congenital and acquired heart disease. The imp
Autor:
Richard B. Chard, Nadia Badawi, Gary F. Sholler, Karen Walker, Megan C. Sherwood, Kai C. Lau, David S. Winlaw, Robert Halliday, Peter W. Grant, Richard E. Hawker, Simon J Dimmick, Ian A. Nicholson, Stephen G. Cooper, Owen Jones
Publikováno v:
Journal of Paediatrics and Child Health. 43:370-375
Aim: To describe cardiac surgery, survival and outcomes for low-birthweight (≤2500 g) infants undergoing surgery for congenital heart disease. Methods: Using data from a prospectively collected population-based database of admissions to neonatal in