Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Megan C Wright"'
Autor:
Mark W Urban, Brittany A Charsar, Nicolette M Heinsinger, Shashirekha S Markandaiah, Lindsay Sprimont, Wei Zhou, Eric V Brown, Nathan T Henderson, Samantha J Thomas, Biswarup Ghosh, Rachel E Cain, Davide Trotti, Piera Pasinelli, Megan C Wright, Matthew B Dalva, Angelo C Lepore
Publikováno v:
eLife, Vol 12 (2024)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron loss. Importantly, non-neuronal cell types such as astrocytes also play significant roles in disease pathogenesis. However, mechanisms of astrocyte contr
Externí odkaz:
https://doaj.org/article/018e0a8bf2cb4c7db4d6c298aaf9f962
Autor:
Andrés Fuentes‐Flores, Cristian Geronimo‐Olvera, Karina Girardi, David Necuñir‐Ibarra, Sandip Kumar Patel, Joanna Bons, Megan C Wright, Daniel Geschwind, Ahmet Hoke, Jose A Gomez‐Sanchez, Birgit Schilling, Daniela L Rebolledo, Judith Campisi, Felipe A Court
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp n/a-n/a (2023)
Abstract Following peripheral nerve injury, successful axonal growth and functional recovery require Schwann cell (SC) reprogramming into a reparative phenotype, a process dependent upon c‐Jun transcription factor activation. Unfortunately, axonal
Externí odkaz:
https://doaj.org/article/81de24a7030f424a99feff5a63cbe0ba
Autor:
Sara Bisetto, Megan C. Wright, Romana A. Nowak, Angelo C. Lepore, Tejvir S. Khurana, Emanuele Loro, Nancy J. Philp
Publikováno v:
iScience, Vol 22, Iss , Pp 507-518 (2019)
Summary: Lactate produced by muscle during high-intensity activity is an important end product of glycolysis that supports whole body metabolism. The lactate shuttle model suggested that lactate produced by glycolytic muscle fibers is utilized by oxi
Externí odkaz:
https://doaj.org/article/ce448164eafd4ade9a76cd5e99222414
Autor:
Lan Cheng, Armin Sami, Biswarup Ghosh, Hannah J. Goudsward, George M. Smith, Megan C. Wright, Shuxin Li, Angelo C. Lepore
Publikováno v:
Neurobiology of Disease, Vol 155, Iss , Pp 105389- (2021)
Promoting the combination of robust regeneration of damaged axons and synaptic reconnection of these growing axon populations with appropriate neuronal targets represents a major therapeutic goal following spinal cord injury (SCI). A key impediment t
Externí odkaz:
https://doaj.org/article/07cfdaa0d5654a6b81d0e28709692bdb
Autor:
Biswarup Ghosh, Jia Nong, Zhicheng Wang, Mark W. Urban, Nicolette M. Heinsinger, Victoria A. Trovillion, Megan C. Wright, Angelo C. Lepore, Yinghui Zhong
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 591-604 (2019)
We tested a biomaterial-based approach to preserve the critical phrenic motor circuitry that controls diaphragm function by locally delivering minocycline hydrochloride (MH) following cervical spinal cord injury (SCI). MH is a clinically-available an
Externí odkaz:
https://doaj.org/article/7aceb4f3d7b04b1c9cce4afadb09635c
Autor:
Lan Cheng, Armin Sami, Biswarup Ghosh, Mark W. Urban, Nicolette M. Heinsinger, Sophia S. Liang, George M. Smith, Megan C. Wright, Shuxin Li, Angelo C. Lepore
Publikováno v:
Neurobiology of Disease, Vol 147, Iss , Pp 105153- (2021)
Chondroitin sulfate proteoglycans (CSPGs), up-regulated in and around the lesion after traumatic spinal cord injury (SCI), are key extracellular matrix inhibitory molecules that limit axon growth and consequent recovery of function. CSPG-mediated inh
Externí odkaz:
https://doaj.org/article/8f970bd3288448ba90f5bc173ddf07a0
Autor:
Eduardo D. Gomes, Biswarup Ghosh, Rui Lima, Miguel Goulão, Tiago Moreira-Gomes, Joana Martins-Macedo, Mark W. Urban, Megan C. Wright, Jeffrey M. Gimble, Nuno Sousa, Nuno A. Silva, Angelo C. Lepore, António J. Salgado
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Cervical spinal cord trauma represents more than half of the spinal cord injury (SCI) cases worldwide. Respiratory compromise, as well as severe limb motor deficits, are among the main consequences of cervical lesions. In the present work, a Gellan G
Externí odkaz:
https://doaj.org/article/fa385cee6e824cd9bc277f1f84ddf5d0
Autor:
Andrés Fuentes-Flores, Cristian Gerónimo-Olvera, David S Necuñir-Ibarra, Sandip Kumar Patel, Joanna Bons, Megan C Wright, Daniel Geschwind, Ahmet Höke, Jose A. Gomez-Sanchez, Birgit Schilling, Judith Campisi, Felipe A Court
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ac576129237e7d27e6bfe66d3675192
https://doi.org/10.15252/rc.2023129749
https://doi.org/10.15252/rc.2023129749
Autor:
Andrés Fuentes-Flores, Cristian Geronimo-Olvera, David Ñecuñir, Sandip Kumar Patel, Joanna Bons, Megan C. Wright, Daniel Geschwind, Ahmet Hoke, Jose A. Gomez-Sanchez, Birgit Schilling, Judith Campisi, Felipe A. Court
After peripheral nerve injuries, successful axonal growth and functional recovery requires the reprogramming of Schwann cells into a reparative phenotype, a process dependent on the activation of the transcription factor c-Jun. Nevertheless, axonal r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3beb98dec921d3ff5c9773381325afb
https://doi.org/10.1101/2022.12.07.519441
https://doi.org/10.1101/2022.12.07.519441
Publikováno v:
American journal of veterinary research. 83(11)
OBJECTIVE To determine whether copper oxide wire particles (COWP) administered as an oral bolus effectively decrease fecal gastrointestinal nematode (GIN) egg counts in adult alpacas. ANIMALS 57 adult alpacas. PROCEDURES A double-blind clinical trial