Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Megan C King"'
Autor:
Luka Maisuradze, Megan C King, Ivan V Surovtsev, Simon G J Mochrie, Mark D Shattuck, Corey S O'Hern
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 7, p e1012221 (2024)
Chromatin is a polymer complex of DNA and proteins that regulates gene expression. The three-dimensional (3D) structure and organization of chromatin controls DNA transcription and replication. High-throughput chromatin conformation capture technique
Externí odkaz:
https://doaj.org/article/a4606330667b41d4995c800ed39bc1ed
Autor:
Emma Carley, Rachel M Stewart, Abigail Zieman, Iman Jalilian, Diane E King, Amanda Zubek, Samantha Lin, Valerie Horsley, Megan C King
Publikováno v:
eLife, Vol 10 (2021)
While the mechanisms by which chemical signals control cell fate have been well studied, the impact of mechanical inputs on cell fate decisions is not well understood. Here, using the well-defined system of keratinocyte differentiation in the skin, w
Externí odkaz:
https://doaj.org/article/6e479b27d684427e9a03b610382df86f
Publikováno v:
eLife, Vol 7 (2018)
Poly(ADP ribose) polymerase inhibitors (PARPi) target cancer cells deficient in homology-directed repair of DNA double-strand breaks (DSBs). In preclinical models, PARPi resistance is tied to altered nucleolytic processing (resection) at the 5’ end
Externí odkaz:
https://doaj.org/article/47216911d4894e1aa2998cb51c89e28c
Autor:
Haiyan Guo, Megan C King
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82758 (2013)
Eukaryotic organisms employ a variety of mechanisms during meiosis to assess and ensure the quality of their gametes. Defects or delays in successful meiotic recombination activate conserved mechanisms to delay the meiotic divisions, but many multice
Externí odkaz:
https://doaj.org/article/2bddd0d7d465466f94b92909e7b8d939
Autor:
Xiao Hu, Zongzhi Z. Liu, Xinyue Chen, Vincent P. Schulz, Abhishek Kumar, Amaleah A. Hartman, Jason Weinstein, Jessica F. Johnston, Elisa C. Rodriguez, Anna E. Eastman, Jijun Cheng, Liz Min, Mei Zhong, Christopher Carroll, Patrick G. Gallagher, Jun Lu, Martin Schwartz, Megan C. King, Diane S. Krause, Shangqin Guo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
MKL1 is a key transcriptional co-activator of actin cytoskeleton genes. Here the authors show that MKL1 activation in somatic cells reduces chromatin accessibility and hinders full reprogramming to pluripotency. Reduction of MKL1, disruption of actin
Externí odkaz:
https://doaj.org/article/39034a1a1b414222967219825619062a
Publikováno v:
Trends in Cell Biology. 32:669-680
The large arrays of cell types in a multicellular organism are defined by their stereotypic size and/or morphology, and, for cells in vivo, by their anatomic positions. Historically, this identity-structure-function correlation was conceptualized as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8deebdeef5fa65429ec48db3a23ed454
https://doi.org/10.1016/j.tcb.2022.02.006
https://doi.org/10.1016/j.tcb.2022.02.006
Autor:
Hawa-Racine Thiam, Pablo Vargas, Nicolas Carpi, Carolina Lage Crespo, Matthew Raab, Emmanuel Terriac, Megan C. King, Jordan Jacobelli, Arthur S. Alberts, Theresia Stradal, Ana-Maria Lennon-Dumenil, Matthieu Piel
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Cell migration through micrometric constraints is limited by low deformability of the nucleus. Here the authors show that in dendritic cells a perinuclear actin network nucleated by Arp2/3 increases nuclear deformation and allows the cells to pass th
Externí odkaz:
https://doaj.org/article/796be198360b48fbb790124ac2cd0cd1
Autor:
Zhanna Hakhverdyan, David J Thaller, Sapan Borah, Megan C. King, Elisa C. Rodriguez, Anthony W Isenhour, C. Patrick Lusk, Michael P. Rout
Publikováno v:
Molecular Biology of the Cell
Integral membrane proteins of the Lap2-emerin-MAN1 (LEM) family have emerged as important components of the inner nuclear membrane (INM) required for the functional and physical integrity of the nuclear envelope. However, like many INM proteins, ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6bc7fa4775e1b7fb6420b9a24e1f11
https://doi.org/10.1091/mbc.e20-09-0584
https://doi.org/10.1091/mbc.e20-09-0584
Autor:
Jing Li, Katelyn Noronha, Parker L. Sulkowski, Sebastian Oeck, Brian Shuch, Megan C. King, Lily Mirfakhraie, Xun Bao, Peter M. Glazer, Jonathan Dow, Nicholas G Economos, Ranjit S. Bindra, Yanfeng Liu
Publikováno v:
Nature
Deregulation of metabolism and disruption of genome integrity are hallmarks of cancer1. Increased levels of the metabolites 2-hydroxyglutarate, succinate and fumarate occur in human malignancies owing to somatic mutations in the isocitrate dehydrogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930f51da546111372a445e8362ccb2f1
http://europepmc.org/articles/PMC7319896
http://europepmc.org/articles/PMC7319896
Publikováno v:
Molecular biology of the cell. 33(4)
Homology-directed repair of DNA double-strand breaks (DSBs) can be a highly faithful pathway. Non-crossover repair dominates in mitotically growing cells, likely through a preference for synthesis-dependent strand annealing (SDSA). While genetic stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1878929620e8549a088e7267969e32
https://pubmed.ncbi.nlm.nih.gov/35080989
https://pubmed.ncbi.nlm.nih.gov/35080989