Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Megan C King"'
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-30 (2024)
Abstract Background Inhomogeneous patterns of chromatin-chromatin contacts within 10–100-kb-sized regions of the genome are a generic feature of chromatin spatial organization. These features, termed topologically associating domains (TADs), have l
Externí odkaz:
https://doaj.org/article/c424b997362a4c11a8b1b8267fdf49cd
Autor:
Luka Maisuradze, Megan C King, Ivan V Surovtsev, Simon G J Mochrie, Mark D Shattuck, Corey S O'Hern
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 7, p e1012221 (2024)
Chromatin is a polymer complex of DNA and proteins that regulates gene expression. The three-dimensional (3D) structure and organization of chromatin controls DNA transcription and replication. High-throughput chromatin conformation capture technique
Externí odkaz:
https://doaj.org/article/a4606330667b41d4995c800ed39bc1ed
Autor:
Jessica F. Williams, Ivan V. Surovtsev, Sarah M. Schreiner, Ziyuan Chen, Gulzhan Raiymbek, Hang Nguyen, Yan Hu, Julie S. Biteen, Simon G.J. Mochrie, Kaushik Ragunathan, Megan C. King
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114373- (2024)
Summary: Biomolecular condensates have emerged as major drivers of cellular organization. It remains largely unexplored, however, whether these condensates can impart mechanical function(s) to the cell. The heterochromatin protein HP1α (Swi6 in Schi
Externí odkaz:
https://doaj.org/article/560c134b16ba4f8898ed966aa2fac233
Autor:
Xiao Hu, Zongzhi Z. Liu, Xinyue Chen, Vincent P. Schulz, Abhishek Kumar, Amaleah A. Hartman, Jason Weinstein, Jessica F. Johnston, Elisa C. Rodriguez, Anna E. Eastman, Jijun Cheng, Liz Min, Mei Zhong, Christopher Carroll, Patrick G. Gallagher, Jun Lu, Martin Schwartz, Megan C. King, Diane S. Krause, Shangqin Guo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
MKL1 is a key transcriptional co-activator of actin cytoskeleton genes. Here the authors show that MKL1 activation in somatic cells reduces chromatin accessibility and hinders full reprogramming to pluripotency. Reduction of MKL1, disruption of actin
Externí odkaz:
https://doaj.org/article/39034a1a1b414222967219825619062a
Autor:
Emma Carley, Rachel M Stewart, Abigail Zieman, Iman Jalilian, Diane E King, Amanda Zubek, Samantha Lin, Valerie Horsley, Megan C King
Publikováno v:
eLife, Vol 10 (2021)
While the mechanisms by which chemical signals control cell fate have been well studied, the impact of mechanical inputs on cell fate decisions is not well understood. Here, using the well-defined system of keratinocyte differentiation in the skin, w
Externí odkaz:
https://doaj.org/article/6e479b27d684427e9a03b610382df86f
Autor:
Hannah L. Klein, Giedrė Bačinskaja, Jun Che, Anais Cheblal, Rajula Elango, Anastasiya Epshtein, Devon M. Fitzgerald, Belén Gómez-González, Sharik R. Khan, Sandeep Kumar, Bryan A. Leland, Léa Marie, Qian Mei, Judith Miné-Hattab, Alicja Piotrowska, Erica J. Polleys, Christopher D. Putnam, Elina A. Radchenko, Anissia Ait Saada, Cynthia J. Sakofsky, Eun Yong Shim, Mathew Stracy, Jun Xia, Zhenxin Yan, Yi Yin, Andrés Aguilera, Juan Lucas Argueso, Catherine H. Freudenreich, Susan M. Gasser, Dmitry A. Gordenin, James E. Haber, Grzegorz Ira, Sue Jinks-Robertson, Megan C. King, Richard D. Kolodner, Andrei Kuzminov, Sarah AE Lambert, Sang Eun Lee, Kyle M. Miller, Sergei M. Mirkin, Thomas D. Petes, Susan M. Rosenberg, Rodney Rothstein, Lorraine S. Symington, Pawel Zawadzki, Nayun Kim, Michael Lisby, Anna Malkova
Publikováno v:
Microbial Cell, Vol 6, Iss 1, Pp 1-64 (2019)
Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These assays have been developed in microbial systems that provide the advantages of genetic and molecular reporters that can readily
Externí odkaz:
https://doaj.org/article/9deb4e4edc524ec78e599b9f614eaef3
Publikováno v:
Trends in Cell Biology. 32:669-680
The large arrays of cell types in a multicellular organism are defined by their stereotypic size and/or morphology, and, for cells in vivo, by their anatomic positions. Historically, this identity-structure-function correlation was conceptualized as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8deebdeef5fa65429ec48db3a23ed454
https://doi.org/10.1016/j.tcb.2022.02.006
https://doi.org/10.1016/j.tcb.2022.02.006
Autor:
Sunyoung Hwang, Jessica F. Williams, Maja Kneissig, Maria Lioudyno, Isabel Rivera, Pablo Helguera, Jorge Busciglio, Zuzana Storchova, Megan C. King, Eduardo M. Torres
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2473-2488.e5 (2019)
Summary: An abnormal number of chromosomes, or aneuploidy, accounts for most spontaneous abortions, causes developmental defects, and is associated with aging and cancer. The molecular mechanisms by which aneuploidy disrupts cellular function remain
Externí odkaz:
https://doaj.org/article/78c6c24f9d924edbbe6dfedfbd9f773e
Autor:
Xavier Lahaye, Takeshi Satoh, Matteo Gentili, Silvia Cerboni, Aymeric Silvin, Cécile Conrad, Abdelhakim Ahmed-Belkacem, Elisa C. Rodriguez, Jean-François Guichou, Nathalie Bosquet, Matthieu Piel, Roger Le Grand, Megan C. King, Jean-Michel Pawlotsky, Nicolas Manel
Publikováno v:
Cell Reports, Vol 15, Iss 4, Pp 879-892 (2016)
During the early phase of replication, HIV reverse transcribes its RNA and crosses the nuclear envelope while escaping host antiviral defenses. The host factor Cyclophilin A (CypA) is essential for these steps and binds the HIV capsid; however, the m
Externí odkaz:
https://doaj.org/article/fe92c4c74c7046739a91e7a5b56b2a1a
Autor:
Hawa-Racine Thiam, Pablo Vargas, Nicolas Carpi, Carolina Lage Crespo, Matthew Raab, Emmanuel Terriac, Megan C. King, Jordan Jacobelli, Arthur S. Alberts, Theresia Stradal, Ana-Maria Lennon-Dumenil, Matthieu Piel
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Cell migration through micrometric constraints is limited by low deformability of the nucleus. Here the authors show that in dendritic cells a perinuclear actin network nucleated by Arp2/3 increases nuclear deformation and allows the cells to pass th
Externí odkaz:
https://doaj.org/article/796be198360b48fbb790124ac2cd0cd1