Imaging conditioned fear circuitry using awake rodent fMRI.

Autor: Nichola M Brydges, Heather C Whalley, Maurits A Jansen, Gavin D Merrifield, Emma R Wood, Stephen M Lawrie, Sara-Madge Wynne, Mark Day, Sue Fleetwood-Walker, Douglas Steele, Ian Marshall, Jeremy Hall, Megan C Holmes

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e54197 (2013)

Functional magnetic resonance imaging (fMRI) is a powerful method for exploring emotional and cognitive brain responses in humans. However rodent fMRI has not previously been applied to the analysis of learned behaviour in awake animals, limiting its

Externí odkaz: https://doaj.org/article/b30e294a49534872a55dd1317e784fbb

Circadian control of mouse heart rate and blood pressure by the suprachiasmatic nuclei: behavioral effects are more significant than direct outputs.

Autor: W John Sheward, Erik Naylor, Seymour Knowles-Barley, J Douglas Armstrong, Gillian A Brooker, Jonathan R Seckl, Fred W Turek, Megan C Holmes, Phyllis C Zee, Anthony J Harmar

Publikováno v: PLoS ONE, Vol 5, Iss 3, p e9783 (2010)

Diurnal variations in the incidence of events such as heart attack and stroke suggest a role for circadian rhythms in the etiology of cardiovascular disease. The aim of this study was to assess the influence of the suprachiasmatic nucleus (SCN) circa

Externí odkaz: https://doaj.org/article/efa5db9a9e8a4907a509ef1e5861b364

High salt intake activates the hypothalamic-pituitary-adrenal axis, amplifies the stress response, and alters tissue glucocorticoid exposure in mice

Autor: Hannah M Costello, Georgios Krilis, Celine Grenier, David Severs, Alicja Czopek, Jessica R Ivy, Mark Nixon, Megan C Holmes, Dawn E W Livingstone, Ewout J Hoorn, Neeraj Dhaun, Matthew A Bailey

Publikováno v: Costello, H, Krilis, G, Grenier, C, Severs, D, Czopek, A, Ivy, J R, Nixon, M, Holmes, M C, Livingstone, D E W, Hoorn, E J, Dhaun, N & Bailey, M A 2022, ' High salt intake activates the hypothalamic-pituitary-adrenal axis, amplifies the stress response, and alters tissue glucocorticoid exposure in mice ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvac160

Aims High salt intake is common and contributes to poor cardiovascular health. Urinary sodium excretion correlates directly with glucocorticoid excretion in humans and experimental animals. We hypothesized that high salt intake activates the hypothal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96df43a514d5a254e7661b3ca6a200a1
https://pubmed.ncbi.nlm.nih.gov/36368681

Editorial overview: Neuroendocrine response to stress

Autor: Ferenc A. Antoni, Megan C. Holmes

Publikováno v: Current Opinion in Endocrine and Metabolic Research. 27:100422

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87c642fbb1a242b5fe03a65af5a86776
https://doi.org/10.1016/j.coemr.2022.100422

Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task

Autor: Kristoffer Højgaard, Betina Elfving, Ove Wiborg, Megan C. Holmes, Lena-Sophie Martis

Publikováno v: Martis, L, Højgaard, K, Holmes, M C, Elfving, B & Wiborg, O 2021, ' Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task ', Scientific Reports . https://doi.org/10.1038/s41598-021-88462-7
Martis, L-S, Højgaard, K, Holmes, M C, Elfving, B & Wiborg, O 2021, ' Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task ', Scientific Reports, vol. 11, 9113 . https://doi.org/10.1038/s41598-021-88462-7
Scientific Reports
Martis, L-S, Højgaard, K, Holmes, M C, Elfving, B & Wiborg, O 2021, ' Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task ', Scientific Reports, vol. 11, no. 1, 9113 . https://doi.org/10.1038/s41598-021-88462-7
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Depression-associated cognitive impairments are among the most prevalent and persistent symptoms during remission from a depressive episode and a major risk factor for relapse. Consequently, development of antidepressant drugs, which also alleviate c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2065b6ab8bb3f449172be8472542b961
https://hdl.handle.net/20.500.11820/f620d8bf-e672-4fbd-ae42-b3223f066970