Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Megan A. Frederick"'
Autor:
Megan A. Frederick, Kaylyn E. Williamson, Meilin Fernandez Garcia, Max B. Ferretti, Ryan L. McCarthy, Greg Donahue, Edgar Luzete Monteiro, Naomi Takenaka, Janice Reynaga, Cigall Kadoch, Kenneth S. Zaret
Publikováno v:
Nature Structural & Molecular Biology. 30:31-37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f9d8687c0c308a0566b15dbc27592d7
https://doi.org/10.1038/s41594-022-00886-5
https://doi.org/10.1038/s41594-022-00886-5
Autor:
Adam J. Getzler, Megan A. Frederick, Justin J. Milner, Thomas Venables, Huitian Diao, Clara Toma, Shashank D. Nagaraja, Dominic S. Albao, Simon Bélanger, Shanel M. Tsuda, Jihye Kim, Shane Crotty, Ananda W. Goldrath, Matthew E. Pipkin
Publikováno v:
bioRxiv
CD8+T cells with stem cell-like properties (TSCM) sustain adaptive immunity to intracellular pathogens and tumors. However, the developmental origins and chromatin regulatory factors (CRFs) that establish their differentiation are unclear. Using an R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d73e585f11a72933734f7f35740eb4
https://doi.org/10.1101/2023.01.18.524461
https://doi.org/10.1101/2023.01.18.524461
Autor:
Megan A, Frederick, Kaylyn E, Williamson, Meilin, Fernandez Garcia, Max B, Ferretti, Ryan L, McCarthy, Greg, Donahue, Edgar, Luzete Monteiro, Naomi, Takenaka, Janice, Reynaga, Cigall, Kadoch, Kenneth S, Zaret
Publikováno v:
Nature structuralmolecular biology.
To determine how different pioneer transcription factors form a targeted, accessible nucleosome within compacted chromatin and collaborate with an ATP-dependent chromatin remodeler, we generated nucleosome arrays in vitro with a central nucleosome co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::178616a782348cc4803dbd4756d3bef2
https://pubmed.ncbi.nlm.nih.gov/36536103
https://pubmed.ncbi.nlm.nih.gov/36536103
Autor:
Jihye Kim, Dapeng Wang, Runqiang Chen, Clara Toma, Huitian Diao, Shane Crotty, Ananda W. Goldrath, Gustavo J. Martinez, Pabalu Karunadharma, Donna M. Martin, J. Justin Milner, Thomas Venables, Shanel Tsuda, Matthew E. Pipkin, Megan A. Frederick, Adam J. Getzler
Individual naive CD8 T cells activated in lymphoid organs differentiate into functionally diverse and anatomically distributed T cell phylogenies in response to intracellular microbes. During infections that resolve rapidly, including live viral vacc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdad561ab24d201361adde2c31ce0001
https://doi.org/10.1101/2021.08.11.456014
https://doi.org/10.1101/2021.08.11.456014
Autor:
Karun Kiani, Sam J. McCright, Maria Fasolino, Weimin Kong, Naomi Goldman, Joseph A. Fraietta, Megan A. Frederick, Wenliang Wang, Benjamin Cattau, Golnaz Vahedi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Chimeric antigen receptors (CARs) have established themselves as a powerful means to redirect the natural properties of T cells against tumors. However, most clinical trials fail due to limited CAR-T cell expansion. Among several factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0969ee09ae0bb671224df10ee6024553
https://pubmed.ncbi.nlm.nih.gov/32094195
https://pubmed.ncbi.nlm.nih.gov/32094195
Autor:
Adam Getzler, Megan A. Frederick, Huitian Diao, Justin Milner, Simon Belanger, Shanel Tsuda, Jihye Kim, Shane Crotty, Ananda W Goldrath, Matthew E. Pipkin
Publikováno v:
The Journal of Immunology. 206:14.08-14.08
CD8+ T cells with stem cell-like qualities (TSTEM) provide central memory following resolved intracellular infections, and serve as progenitor cells that sustain effector-like cell development during chronic infections and tumors, both naturally and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1abfa85acc7522831e47e969db0c4590
https://doi.org/10.4049/jimmunol.206.supp.14.08
https://doi.org/10.4049/jimmunol.206.supp.14.08
Autor:
Megan A. Frederick, Masahide Asano, Ngoc T Ha, Michael Sun, Rani E. George, Duc-Hung Pham, Chie Naruse, To-Ha Thai, Matthew E. Pipkin, Bandana Sharma
Publikováno v:
Scientific Reports
Cbx3/HP1γ is a histone reader whose function in the immune system is not completely understood. Here, we demonstrate that in CD8+ T cells, Cbx3/HP1γ insufficiency leads to chromatin remodeling accompanied by enhanced Prf1, Gzmb and Ifng expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2134bacb69137b58edfea525c028c6f
http://europepmc.org/articles/PMC5318867
http://europepmc.org/articles/PMC5318867
Autor:
Runqiang Chen, Anjana Rao, Simon Bélanger, Nengming Xiao, Yun-Cai Liu, Matthew E. Pipkin, Bin Li, Sonia Sharma, Shane Crotty, Robert J. Johnston, Megan A. Frederick, Bjoern Peters
Publikováno v:
Immunity. 41(2):325-338
Summary Classical genetic approaches to examine the requirements of genes for T cell differentiation during infection are time consuming. Here we developed a pooled approach to screen 30–100+ genes individually in separate antigen-specific T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7955c426cc021ebdb3911e47979c57f
Autor:
Bingfei Yu, Ananda W. Goldrath, Megan A. Frederick, Adam J. Getzler, J. Justin Milner, Dapeng Wang, Walter Rogal, Shane Crotty, Matthew E. Pipkin, Huitian Diao
Publikováno v:
Immunity. 48:659-674.e6
Summary T cell receptor (TCR) stimulation of naive CD8+ T cells initiates reprogramming of cis-regulatory landscapes that specify effector and memory cytotoxic T lymphocyte (CTL) differentiation. We mapped regions of hyper-accessible chromatin in nai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0719d063f47757bec48467feaf61e5
https://doi.org/10.1016/j.immuni.2018.03.028
https://doi.org/10.1016/j.immuni.2018.03.028