Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance

Autor: Beverley Robertson, Adam Davie, Stuart M. Haslam, Huan Cao, Wendy J Pickford, Heather M. Wilson, Robert N. Barker, Heather J. Wassall, Gordon D. Brown, Sadie Henderson, Anne Dell, Aristotelis Antonopoulos, Megan A Forrester, J. Alexandra Rowe, Bhinal Patel, Gabriela Konieczny, Mark A. Vickers, Dimitris Tampakis, Michael Moss, Lindsay S Hall, Maria-Louise Williams, Beverley E. Minter, David C. Rees, John N. Brewin, Lars Erwig, Charlotte S. Lennon, Jenna Shepherd, Alanna Masson

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Cao, H, Antonopoulos, A, Henderson, S, Wassall, H, Brewin, J, Masson, A, Shepherd, J, Konieczny, G, Patel, B, Williams, M-L, Davie, A, Forrester, M A, Hall, L, Minter, B, Tampakis, D, Moss, M, Lennon, C, Pickford, W, Erwig, L, Robertson, B, Dell, A, Brown, G D, Wilson, H M, Rees, D C, Haslam, S M, Alexandra Rowe, J, Barker, R N & Vickers, M A 2021, ' Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance ', Nature Communications, vol. 12, no. 1, 1792 . https://doi.org/10.1038/s41467-021-21814

In both sickle cell disease and malaria, red blood cells (RBCs) are phagocytosed in the spleen, but receptor-ligand pairs mediating uptake have not been identified. Here, we report that patches of high mannose N-glycans (Man5-9GlcNAc2), expressed on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd89a3aee2973519b6303389fca5a20d
http://hdl.handle.net/10044/1/89825

Similarities and differences in surface receptor expression by THP-1 monocytes and differentiated macrophages polarized using seven different conditioning regimens

Autor: Huan Cao, Robert N. Barker, Megan A Forrester, Mark A. Vickers, Heather M. Wilson, Heather J. Wassall, Lindsay S Hall

Publikováno v: Cell Immunol

Macrophages are key in orchestrating immune responses to micro-environmental stimuli, sensed by a complex set of surface receptors. The human cell line THP-1 has a monocytic phenotype, including the ability to differentiate into macrophages, providin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c3da4833fc41bf9ea4deffa8a36e4e
https://doi.org/10.1016/j.cellimm.2018.07.008

Exteriorisation of Mannoses on Human Erythrocyte Membrane Skeleton Provides 'Eat Me' Signals for Oxidatively Damaged Cells to be Cleared By Macrophages: A Pathway Mediating Hemolysis in Sickle Cell Disease

Autor: Minter Beverly, Sadie Henderson, Robert N. Barker, Stuart M. Haslam, Michael Moss, Maria-Louise Williams, Dimitrios Tampakis, Heather M. Wilson, Heather J. Wassall, Huan Cao, Jenna Shepherd, Lindsay S Hall, David C. Rees, Megan A Forrester, Gabriela Konieczny, Mark A. Vickers

Publikováno v: Blood. 130:919-919

The disposal of unwanted or dying cells is a key biological process driven by the display of 'eat me' signals that are recognised by phagocytes. Although these markers for uptake are known to include certain lipids and proteins, the role of glycans,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb75ef7d10a5e2707ea3683948b036f
https://doi.org/10.1182/blood.v130.suppl_1.919.919