Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Megan A Girtman"'
Autor:
Brendan K Reed, Laura B Chopp, Courtney S Malo, Danielle N Renner, Virginia S Van Keulen, Megan A Girtman, Wendy N Nevala, Kevin D Pavelko, Diana Gil, Adam G Schrum, Aaron J Johnson, Larry R Pease
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137984 (2015)
Antigen-specific T cell responses can be visualized using MHC:peptide multimers. In cases where robust T cell controls are not readily available to assess the integrity of multimer reagents prior to analyzing limited sample, the ability to assess the
Externí odkaz:
https://doaj.org/article/1fb448f2255f452cad3fed8f44b99cae
Autor:
Kevin D Pavelko, Megan A Girtman, Yoshihiro Mitsunaga, Yanice V Mendez-Fernandez, Michael P Bell, Michael J Hansen, Kathleen S Allen, Moses Rodriguez, Larry R Pease
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20217 (2011)
The induction of sterilizing T-cell responses to tumors is a major goal in the development of T-cell vaccines for treating cancer. Although specific components of anti-viral CD8+ immunity are well characterized, we still lack the ability to mimic vir
Externí odkaz:
https://doaj.org/article/e5ea32cb816042768471f0c82d886e5e
Publikováno v:
Breast Cancer Research and Treatment. 179:653-660
The epidermal growth factor receptor ligand, Amphiregulin, is a transcriptional target of estrogen receptor alpha and is required for pubertal mammary gland development. Previous studies using immortalized human breast cancer cell line xenografts hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f54f78ce7604158a553d41dce35932
https://doi.org/10.1007/s10549-019-05507-2
https://doi.org/10.1007/s10549-019-05507-2
Autor:
Paraic A. Kenny, Megan A. Girtman, Meagan E. Campbell, William M. Rehrauer, Craig S. Richmond
While considerable success has been achieved with treating BRAF-V600E mutant tumors in several organ systems, tumors expressing non-V600E BRAF mutations remain a significant clinical challenge. Such atypical BRAF mutations are classified based on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1b59c5d17f66d7083ab4485c2dcc799
https://doi.org/10.1101/2021.08.20.457149
https://doi.org/10.1101/2021.08.20.457149
BackgroundBRAF, when mutated at V600E, is a potent oncogenic driver in melanoma, lung and colorectal cancer with well understood signaling mechanisms and established treatment guidelines. Non-V600E mutations are less common, more functionally diverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d313c691f4fe044ae5ec5f153a89015
https://doi.org/10.1101/2021.07.22.453427
https://doi.org/10.1101/2021.07.22.453427
Autor:
Kristopher A. Lofgren, CR Vos, Paraic A. Kenny, Craig S. Richmond, Jake A Deviley, Meier, Megan A. Girtman
Publikováno v:
Cancer Research. 79:P5-10
At our center, a standard 25 gene panel has proved useful for the identification of pathogenic germline mutations in many families with a high penetrance of breast and ovarian cancer, yet there remain several families with very high cancer incidence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c551871d39bb3c9bff5d09be3c1f1cc
https://doi.org/10.1158/1538-7445.sabcs18-p5-10-04
https://doi.org/10.1158/1538-7445.sabcs18-p5-10-04
Autor:
JuneMee Chae, Theodore J. Kottom, Andrew H. Limper, Megan A. Girtman, Michael H Bourne, Paige Jenson, Cassandra M. Braun
AimsSuccessful management of IPF will likely require multi-drug therapy as its pathogenesis is thought to be both driven by both pro-inflammatory and pro-fibrotic pathways. We hypothesized that the available anti-fibrotic agents, pirfenidone and nint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::540f1eedcb48d4e27ca9514d6765cfa3
https://doi.org/10.1101/2020.06.29.178061
https://doi.org/10.1101/2020.06.29.178061
Autor:
Eva M. Carmona, Andrew H. Limper, Megan A. Girtman, Mohamed F. Ali, Andrew J. Haak, Daniel J. Tschumperlin
Pirfenidone recently received FDA approval as one of the first two drugs designed to treat idiopathic pulmonary fibrosis. While the clinical data continues to support the efficacy of pirfenidone, the specific molecular mechanism of action of this dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ee941815b70b3cf58e2e0d11a4a326
https://europepmc.org/articles/PMC5581985/
https://europepmc.org/articles/PMC5581985/
Autor:
Kristopher A. Lofgren, Paraic A. Kenny, Megan A. Girtman, Esther A. Peterson, E. Charles Jenkins, David R. Meier
Publikováno v:
Cancer Research. 78:2522-2522
Amphiregulin (AREG) is an estrogen-responsive ligand of the epidermal growth factor receptor. Mice with germline deletion of AREG are defective in pubertal mammary expansion. Using shRNA, we have previously reported that the estrogen-responsive growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75a51474d8cd94c550dfbe4960f04fcd
https://doi.org/10.1158/1538-7445.am2018-2522
https://doi.org/10.1158/1538-7445.am2018-2522
Autor:
Siaw Li Chan, Michael J. Hansen, Lonn D. Lindquist, Megan A. Girtman, Larry R. Pease, Richard J. Bram
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 195(12)
Calcium-modulating cyclophilin ligand (CAML) is an endoplasmic reticulum resident protein that is widely expressed. Although it has been demonstrated to participate in the tail-anchored protein insertion pathway, its physiological role in the mature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ff59d649b2ef835bf7c0181f69c0b6
https://pubmed.ncbi.nlm.nih.gov/26561552
https://pubmed.ncbi.nlm.nih.gov/26561552