Zobrazeno 1 - 10
of 1 412
pro vyhledávání: '"Megakaryocytic"'
Autor:
Xin Yuan, Pengcong Liu, Lei Xu, Liqing Liang, Qian Dong, Tao Fan, Wen Yue, Mingyi Qu, Xuetao Pei, Xiaoyan Xie
Publikováno v:
Thrombosis Journal, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background Proper control of the lineage bias of megakaryocytic and erythroid progenitor cells (MEPs) is of significant importance, the disorder of which will lead to abnormalities in the number and function of platelets and erythrocytes. Un
Externí odkaz:
https://doaj.org/article/ebe30320e04c4b4f8d56f918d1b1637d
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Background Megakaryocytic differentiation is a complicated process regulated by a series of transcription factors in a context- and stage-dependent manner. Recent studies have suggested that krüppel-like transcription factor 2 (KLF2) is inv
Externí odkaz:
https://doaj.org/article/006725ce268042638058018c3814d204
Autor:
Yuki Tanaka, Yuri Nakanishi, Erina Furuhata, Ken-ichi Nakada, Rino Maruyama, Harukazu Suzuki, Takahiro Suzuki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Familial platelet disorder with associated myeloid malignancies (FPDMM) is an autosomal dominant disease caused by heterozygous germline mutations in RUNX1. It is characterized by thrombocytopenia, platelet dysfunction, and a predisposition
Externí odkaz:
https://doaj.org/article/a8d345d8c8054bdaa2f92711c813a6b2
Publikováno v:
Global Medical Genetics, Vol 11, Iss 02, Pp 159-166 (2024)
Purpose To analyze the factors affecting the mobilization efficiency of hematopoietic stem cells and hematopoietic reconstruction indicators during autologous peripheral hematopoietic stem cell transplantation.
Externí odkaz:
https://doaj.org/article/a86ebad1f9f04174808e16c12f4dba3d
Publikováno v:
Journal of Clinical and Diagnostic Research, Vol 18, Iss 04, Pp 07-12 (2024)
Introduction: The spectrum of haematological and non haematological disorders is vast in various age groups. Complete blood counts and other routine laboratory tests are not always sufficient to diagnose these diseases. Bone marrow examination plays
Externí odkaz:
https://doaj.org/article/77eb19567685424e912705ef45d7f2e4
Autor:
Seonhwa Hwang, Min-Seo Park, Anthony Junhoe Koo, Eunsoo Yoo, Seh-Hyon Song, Hye-Kyung Kim, Min-Hi Park, Jae-Seon Kang
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1257 (2024)
Platelets are essential blood components that maintain hemostasis, prevent excessive bleeding, and facilitate wound healing. Reduced platelet counts are implicated in various diseases, including leukemia, hepatitis, cancer, and Alzheimer’s disease.
Externí odkaz:
https://doaj.org/article/5dc79d4015ab4f1dbc1fe77378f6efe3
Autor:
Jae-Hyun Jo, Jong-Uk Park, Yeong-Mu Kim, Seon-Mi Ok, Dong-Kyu Kim, Dong-Hyun Jung, Hye-Ji Kim, Hyun-A Seong, Hyo Je Cho, Jihoon Nah, Sangjune Kim, Haiqing Fu, Christophe E. Redon, Mirit I. Aladjem, Sang-Min Jang
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background Megakaryocytes (MKs) are platelet precursors, which arise from hematopoietic stem cells (HSCs). While MK lineage commitment and differentiation are accompanied by changes in gene expression, many factors that modulate megakaryopoi
Externí odkaz:
https://doaj.org/article/491ba279b8ea4325a3b65829219d8458
Autor:
Valérian Rivet, Vincent Sibaud, Jérémie Dion, Thibaut Volosov, Mélanie Biteau, Andréa Pastissier, Karen Delavigne, Pierre Cougoul, Odile Rauzy, Thibault Comont
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionImmune checkpoint inhibitors (ICIs) are used in several advanced malignancies and may cause various immune-related adverse events (irAEs). Among them, hematological irAEs are less described. Acquired amegakaryocytic thrombocytopenia (AAT)
Externí odkaz:
https://doaj.org/article/bba72c905eee4b4facc38b47d1aad356
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Peripheral circadian clocks control cell proliferation and survival, but little is known about their role and regulation in megakaryocytic cells. N-methyl-D-aspartate receptor (NMDAR) regulates the central clock in the brain. The purpose of this stud
Externí odkaz:
https://doaj.org/article/afeb4773c4bc4f6b93c64575c2ed336c
Autor:
Wenzhi Zhang, Jianxin Dun, Hui Li, Jingzhen Liu, Hongbo Chen, Hui Yu, Jiawei Xu, Fen Zhou, Yining Qiu, Jinjin Hao, Qun Hu, Xiaoyan Wu
Publikováno v:
Hematology, Vol 28, Iss 1 (2023)
ABSTRACTBackground Acute megakaryoblastic leukemia (AMKL) without Down syndrome (non-DS-AMKL) usually a worse outcome than DS-AMKL. Acquired trisomy 21(+21) was one of the most common cytogenetic abnormalities in non-DS-AMKL. Knowledge of the differe
Externí odkaz:
https://doaj.org/article/81afff584e404d77b621a39760d1809e