Výsledky vyhledávání - "Megakaryocytes/physiology"

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

Autor: Jan Heyckendorf, Elisa Rosati, Jens Stoye, Andreas Dräger, Alex K. Shalek, Daniela Bezdan, Norbert Frey, Ulisses Nunes da Rocha, Thomas Bahmer, Simon Imm, Antoine-Emmanuel Saliba, Markus Landthaler, Ezio Bonifacio, Maria Colme-Tatche, Annika Schaffarzyk, Alexander Sczyrba, Dora Bordoni, David Ellinghaus, Christoph Lange, Stefan Janssen, Nicholas E. Banovich, Laure-Emmanuelle Zaragosi, Markus M. Nöthen, Anette Friedrichs, Alexander M. Tsankov, Teide Boysen, Andreas Glück, Philipp H. Schiffer, Lena Best, Oliver Eickelberg, Silke Peter, Nathan Baran, Maarten van den Berge, Oliver Kohlbacher, Anna R. Poetsch, Michael Hummel, Ulf Geisen, Dagmar Wieczorek, Alexander T. Dilthey, Burkhard Brandt, Kerstin B. Meyer, Christian Mertes, Jonas Schulte-Schrepping, Florian Tran, Birgit Sawitzki, Hauke Busch, Christoph Klein, Christos Samakovlis, Niklaus Rajewsky, Joachim Schultze, Sören Franzenburg, Jörn Walter, Sina Kaiser, Jörg Vogel, Niklas Bruse, Marc P. Hoeppner, Muzlifa Haniffa, Alina Renz, Purushothama Rao Tata, Stephan Ripke, Ralf Junker, Michael von Papen, Jonathan A. Kropski, Max von Kleist, Oliver Stegle, Neha Mishra, Jörg Overmann, Johanna I. Blase, Nicole Fischer, Jeffrey A. Whitsett, Sarah A. Teichmann, Birte Kehr, Domagoj Schunk, Julia Fischer, Andreas Diefenbach, Joakim Lundeberg, Matthijs Kox, Klaus-Peter Wandinger, Michael Forster, Ingo Kurth, Johannes Zimmermann, Yang Li, René Kallies, Petra Bacher, Torsten Hain, Joachim L. Schultze, Clemens Lier, Klaus Pfeffer, Michael Wittig, Jacob Nattermann, Paul A. Reyfman, Peter Nürnberg, Alfred Pühler, Andre Franke, Markus Ralser, Peter Pickkers, Andreas Keller, Matthias Lindner, Philipp Köhler, Dana Pe'er, Gunnar Elke, Jan Rybniker, Jonathan Josephs-Spaulding, Alexander Goesmann, Anke Becker, Aviv Regev, Ying H. Kan, Alexander Bartholomäus, Rainer Noth, Jonathan Dörr, Julia-Stefanie Frick, Stephan Ossowski, Bimba F. Hoyer, Peter Horvath, Jose Ordovas Montanes, Dirk Skowasch, Philip Rosenstiel, Georg Laue, Oliwia Makarewicz, Stefan Schreiber, Alexander Scheffold, Christoph Röcken, Leif E. Sander, Manja Marz, Joana P. Bernardes, Jörn Kalinowski, Uwe Ohler, Robert Markewitz, Jason R. Spence, Robert Lafyatis, Thomas Ulas, Peer Bork, Tushar J. Desai, Janne Vehreschild, Janina Fuß, Olaf Rieß, Robert Bals, Klaus F. Rabe, Jacob Hamm, Martijn C. Nawijn, John Ziebuhr, Angel Angelov, Fabian J. Theis, Rainer Knoll, Jan O. Korbel, Thomas Clavel, Konrad U. Förstner, Jan Rupp, Sarah Kim-Hellmuth, Christoph Kaleta, Alice C. McHardy, Anna C. Aschenbrenner, Emma L. Rawlins, Douglas P. Shepherd, Julien Gagneur, Marko Nikolic, Georgios Marinos, Jeanette Franzenburg, Eva-Christina Schulte, Axel Künstner, Andreas Walker, Finn Hinrichsen, Kerstin U. Ludwig

Publikováno v: Immunity, 53, 1296-1314.e9
Immunity, 53(6), 1296-1314.e9. CELL PRESS
Immunity 53(6), 1296-1314.e9 (2020). doi:10.1016/j.immuni.2020.11.017
Immunity
Immunity, 53, 6, pp. 1296-1314.e9
1314.e9
United States

Temporal resolution of cellular features associated with a severe COVID-19 disease trajectory is required for understanding skewed immune responses and finding outcome predictors. Here, we performed a longitudinal multi-omics study using a two-centre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9ae7fbbaa61a6ed5bec38333230f7e
https://doi.org/10.1016/j.immuni.2020.11.017

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Rasa3 controls turnover of endothelial cell adhesion and vascular lumen integrity by a Rap1-dependent mechanism

Autor: Molina-Ortiz, Patricia, Orban, Tanguy, Martin, Maud, Habets, Audrey, Dequiedt, Franck, Schurmans, Stéphane

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 14, Iss 1, p e1007195 (2018)
PLOS genetics, 14 (1

Rasa3 is a GTPase activating protein of the GAP1 family which targets R-Ras and Rap1. Although catalytic inactivation or deletion of Rasa3 in mice leads to severe hemorrhages and embryonic lethality, the biological function and cellular location of R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::30f36a0b93b028247f74d9913c0eb9b0
http://europepmc.org/articles/PMC5806903

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Connexin 37 limits thrombus propensity by downregulating platelet reactivity

Autor: Angelillo-Scherrer Anne, Fontana Pierre, Burnier Laurent, Roth Isabelle, Sugamele Rocco, Brisset Anne, Morel Sandrine, Nolli Séverine, Sutter Esther, Chassot Alexandra, Capron Claude, Borgel Delphine, Saller François, Chanson Marc, Kwak Brenda R, Waltenberger Johannes, Weber Christian, Tokgözoglu Lale

Publikováno v: Circulation
Circulation, Vol. 124, No 8 (2011) pp. 930-9

Background— Formation of platelet plug initiates hemostasis after vascular injury and triggers thrombosis in ischemic disease. However, the mechanisms leading to the formation of a stable thrombus are poorly understood. Connexins comprise a family

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b045e2cf5002be404c4f80a56d6620a

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Inhibition of human megakaryocytopoiesis in vitro by platelet factor 4 (PF4) and a synthetic COOH-terminal PF4 peptide

Autor: S Niewiarowski, Alan M. Gewirtz, Bruno Calabretta, W Y Xu, B Rucinski

We report that highly purified human platelet factor 4 (PF4) inhibits human megakaryocytopoiesis in vitro. At greater than or equal to 25 micrograms/ml, PF4 inhibited megakaryocyte colony formation approximately 80% in unstimulated cultures, and appr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b0d4fd46449fa277fb18ce575dba54
https://hdl.handle.net/11380/811511