Mutagenic analysis of Hazara nairovirus non-translated regions during single and multi-step growth identifies both attenuating and functionally-critical sequences for virus replication

Autor: Mega, DF, Fuller, J, Álvarez-Rodríguez, B, Mankouri, J, Hewson, R, Barr, JN

Hazara nairovirus (HAZV) is a member of the Nairoviridae family within the Bunyavirales order, and closely-related to Crimean-Congo hemorrhagic fever virus that is responsible for severe and fatal human disease. The HAZV genome comprises three segmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::361986015c853a1dd58c70c3ccdadbdb

Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19.

Autor: Clark JJ; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, UK., Penrice-Randal R; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, UK., Sharma P; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, UK., Dong X; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, UK., Pennington SH; Department of Tropical Disease Biology, Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Marriott AE; Department of Tropical Disease Biology, Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Colombo S; Department of Tropical Disease Biology, Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Davidson A; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol BS8 1QU, UK., Kavanagh Williamson M; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol BS8 1QU, UK., Matthews DA; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol BS8 1QU, UK., Turtle L; Department of Clinical Infection Microbiology and Immunology and NIHR Health Protection Research Unit for Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 3BX, UK.; Tropical & Infectious Disease Unit, Royal Liverpool University Hospital, Liverpool L7 8YE, UK., Prince T; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, UK., Hughes GL; Departments of Vector Biology and Tropical Disease Biology, Centre for Neglected Tropical Disease, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Patterson EI; Departments of Vector Biology and Tropical Disease Biology, Centre for Neglected Tropical Disease, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Shawli G; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, UK., Mega DF; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, UK., Subramaniam K; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, UK., Sharp J; Department of Pharmacology and Therapeutics, Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool L69 3BX, UK., Turner JD; Department of Tropical Disease Biology, Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Biagini GA; Department of Tropical Disease Biology, Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Owen A; Department of Pharmacology and Therapeutics, Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool L69 3BX, UK., Kipar A; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, UK.; Laboratory for Animal Model Pathology, Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, 8057 Zürich, Switzerland., Hiscox JA; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, UK.; College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang 712100, China.; Infectious Diseases Horizontal Technology Centre (ID HTC), Agency for Science, Technology and Research (A*STAR), Singapore 138632, Singapore., Stewart JP; Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, UK.; College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang 712100, China.; Department of Infectious Disease, University of Georgia, Athens, GA 30602, USA.

Publikováno v: Viruses [Viruses] 2024 May 28; Vol. 16 (6). Date of Electronic Publication: 2024 May 28.

Mutagenic Analysis of Hazara Nairovirus Nontranslated Regions during Single- and Multistep Growth Identifies both Attenuating and Functionally Critical Sequences for Virus Replication.

Autor: Mega DF; School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom., Fuller J; School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom., Álvarez-Rodríguez B; School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom., Mankouri J; School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom., Hewson R; National Infection Service, Public Health England, Porton Down, Salisbury, United Kingdom., Barr JN; School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom j.n.barr@leeds.ac.uk.

Publikováno v: Journal of virology [J Virol] 2020 Aug 17; Vol. 94 (17). Date of Electronic Publication: 2020 Aug 17 (Print Publication: 2020).