Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Meg L Byrne"'
Autor:
Jong-Eun Park, Meg L. Byrne, Nikolaos Patikas, Stefanie Foskolou, Andrew R. Bassett, Sarah F. Field, Hugo J. R. Fernandes, Emmanouil Metzakopian
Publikováno v:
Cell reports. 33(2)
Summary The advent of induced pluripotent stem cell (iPSC)-derived neurons has revolutionized Parkinson's disease (PD) research, but single-cell transcriptomic analysis suggests unresolved cellular heterogeneity within these models. Here, we perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd643664311ee8ec58ceb464bd9a718
https://pubmed.ncbi.nlm.nih.gov/33053338
https://pubmed.ncbi.nlm.nih.gov/33053338
Publikováno v:
Methods in Molecular Biology ISBN: 9781493991693
Genome editing using the CRISPR/Cas9 system has rapidly established itself as an essential tool in the genetic manipulation of many organisms, including human cell lines. Its application to human induced pluripotent stem cells (hiPSCs) allows for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12caa1ee7e6e4de4eb1116c03ab9d23a
https://doi.org/10.1007/978-1-4939-9170-9_11
https://doi.org/10.1007/978-1-4939-9170-9_11
Autor:
Meg L Byrne, Jennifer L Badger, Chris Mason, Maeve A. Caldwell, Farlan S. Veraitch, Ivan Wall
Aim: Hypoxia is used within in vitro stem cell culture to recreate conditions similar to the in vivo environment surrounding the early blastocyst, from which embryonic stem cells can be isolated. Traditionally, basic research has used a coculture fee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fbe0ca098aa6b985142c6256e3b575
https://doi.org/10.2217/rme.12.55
https://doi.org/10.2217/rme.12.55
Autor:
SJ Tyler, Tilo Kunath, Shelley J Allen, Gilles Bru-Mercier, Jihoon Jo, Lucy A. Crompton, Jennifer L Badger, Maeve A. Caldwell, Kwangwook Cho, Hannah Taylor, Peter A. Barbuti, Talitha L Kerrigan, Meg L Byrne
Basal forebrain cholinergic neurons (bfCNs) which provide innervation to the hippocampus and cortex, are required for memory and learning, and are primarily affected in Alzheimer's Disease (AD), resulting in related cognitive decline. Therefore gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48306af86a6a1f0dfc910fdda9c41ea
https://ora.ox.ac.uk/objects/uuid:2cef6ff4-2d3f-4cd9-a781-7738c7bae684
https://ora.ox.ac.uk/objects/uuid:2cef6ff4-2d3f-4cd9-a781-7738c7bae684