Scale-up of the manufacturing process to produce docetaxel-loaded mPEG- b-p(HPMA-Bz) block copolymer micelles for pharmaceutical applications

Autor: Bresseleers, Jaleesa, Bagheri, Mahsa, Storm, Gert, Metselaar, Josbert M., Hennink, Wim E., Meeuwissen, Silvie A., Van Hest, Jan C.M., Afd Pharmaceutics, Pharmaceutics

Publikováno v: Organic Process Research and Development, 23(12), 2707-2715. American Chemical Society
Organic Process Research and Development, 23(12), 2707. American Chemical Society
Organic Process Research & Development

An efficient, scalable, and good manufacturing practice (GMP) compatible process was developed for the production of docetaxel-loaded poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) micelles. First, the synthesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb57197b2ceee30c02f2eee3b8e4873
http://www.scopus.com/inward/record.url?scp=85075127594&partnerID=8YFLogxK

Effect of formulation and processing parameters on the size of mPEG-b-p(HPMA-Bz) polymeric micelles

Autor: Bagheri, Mahsa, Bresseleers, Jaleesa, Varela Moreira, Aida, Sandre, Olivier, Meeuwissen, Silvie A, Schiffelers, Raymond M, Metselaar, Josbert M, van Nostrum, Cornelus F, van Hest, Jan C M, Hennink, Wim E, Afd Pharmaceutics, Pharmaceutics

Publikováno v: Langmuir
Langmuir, American Chemical Society, 2018, 34 (50), pp.15495-15506. ⟨10.1021/acs.langmuir.8b03576⟩
Langmuir, 34(50). American Chemical Society : Division of Carbohydrate Chemistry
Langmuir : the ACS journal of surfaces and colloids 34(50), 15495-15506 (2018). doi:10.1021/acs.langmuir.8b03576
Langmuir, 34(50), 15495-15506. American Chemical Society
Langmuir, 2018, 34 (50), pp.15495-15506. ⟨10.1021/acs.langmuir.8b03576⟩

Micelles composed of block copolymers of poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) have shown great promise as drug-delivery carriers due to their excellent stability and high loading capacity. In the prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4fbf9d7c9643b0be792b92e176f29ca
https://doi.org/10.1021/acs.langmuir.8b03576

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