Comparing deep learning and pathologist quantification of cell-level PD-L1 expression in non-small cell lung cancer whole-slide images.

Autor: van Eekelen L; Department of Pathology, Radboud University Medical Center, P.O.Box 9101, 6500 HB, Nijmegen, The Netherlands. leander.vaneekelen@radboudumc.nl., Spronck J; Department of Pathology, Radboud University Medical Center, P.O.Box 9101, 6500 HB, Nijmegen, The Netherlands., Looijen-Salamon M; Department of Pathology, Radboud University Medical Center, P.O.Box 9101, 6500 HB, Nijmegen, The Netherlands., Vos S; Department of Pathology, Radboud University Medical Center, P.O.Box 9101, 6500 HB, Nijmegen, The Netherlands., Munari E; Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Girolami I; Department of Pathology, Provincial Hospital of Bolzano (SABES-ASDAA), Bolzano-Bozen, Italy., Eccher A; Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy., Acs B; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., Boyaci C; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., de Souza GS; Department of Pathology, Radboud University Medical Center, P.O.Box 9101, 6500 HB, Nijmegen, The Netherlands., Demirel-Andishmand M; Department of Pathology, Radboud University Medical Center, P.O.Box 9101, 6500 HB, Nijmegen, The Netherlands., Meesters LD; Department of Pathology, Radboud University Medical Center, P.O.Box 9101, 6500 HB, Nijmegen, The Netherlands., Zegers D; Department of Pathology, Radboud University Medical Center, P.O.Box 9101, 6500 HB, Nijmegen, The Netherlands., van der Woude L; Department of Pathology, Radboud University Medical Center, P.O.Box 9101, 6500 HB, Nijmegen, The Netherlands., Theelen W; Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., van den Heuvel M; Respiratory Diseases Department, Radboud University Medical Center, Nijmegen, The Netherlands., Grünberg K; Department of Pathology, Radboud University Medical Center, P.O.Box 9101, 6500 HB, Nijmegen, The Netherlands., van Ginneken B; Department of Radiology, Radboud University Medical Center, Nijmegen, The Netherlands., van der Laak J; Department of Pathology, Radboud University Medical Center, P.O.Box 9101, 6500 HB, Nijmegen, The Netherlands., Ciompi F; Department of Pathology, Radboud University Medical Center, P.O.Box 9101, 6500 HB, Nijmegen, The Netherlands.

Publikováno v: Scientific reports [Sci Rep] 2024 Mar 26; Vol. 14 (1), pp. 7136. Date of Electronic Publication: 2024 Mar 26.

Investigations into the FLG Null Phenotype: Showcasing the Methodology for CRISPR/Cas9 Editing of Human Keratinocytes.

Autor: Smits JPH; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Dermatology, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., van den Brink NJM; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Meesters LD; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Molecular Developmental Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Hamdaoui H; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Niehues H; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Jansen PAM; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., van Vlijmen-Willems IMJJ; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Rodijk-Olthuis D; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Evrard C; Molecular Physiology Research Unit, NAmur Research Institute for Life Sciences, University of Namur, Namur, Belgium., Poumay Y; Molecular Physiology Research Unit, NAmur Research Institute for Life Sciences, University of Namur, Namur, Belgium., van Geel M; Department of Dermatology, Maastricht University Medical Center+, Maastricht, The Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands; Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht, The Netherlands., Hendriks WJAJ; Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Schalkwijk J; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Zeeuwen PLJM; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., van den Bogaard EH; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: ellen.vandenbogaard@radboudumc.nl.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2023 Aug; Vol. 143 (8), pp. 1520-1528.e5. Date of Electronic Publication: 2023 Mar 07.

Gram-positive anaerobic cocci guard skin homeostasis by regulating host-defense mechanisms.

Autor: van der Krieken DA; Department of Dermatology, Radboud University Medical Center (Radboudumc), 6500HB Nijmegen, the Netherlands., Rikken G; Department of Dermatology, Radboud University Medical Center (Radboudumc), 6500HB Nijmegen, the Netherlands., Ederveen THA; Center for Molecular and Biomolecular Informatics (CMBI), Radboudumc, 6500HB Nijmegen, the Netherlands., Jansen PAM; Department of Dermatology, Radboud University Medical Center (Radboudumc), 6500HB Nijmegen, the Netherlands., Rodijk-Olthuis D; Department of Dermatology, Radboud University Medical Center (Radboudumc), 6500HB Nijmegen, the Netherlands., Meesters LD; Department of Dermatology, Radboud University Medical Center (Radboudumc), 6500HB Nijmegen, the Netherlands., van Vlijmen-Willems IMJJ; Department of Dermatology, Radboud University Medical Center (Radboudumc), 6500HB Nijmegen, the Netherlands., van Cranenbroek B; Laboratory Medicine, Laboratory of Medical Immunology, Radboudumc, 6500HB Nijmegen, the Netherlands., van der Molen RG; Laboratory Medicine, Laboratory of Medical Immunology, Radboudumc, 6500HB Nijmegen, the Netherlands., Schalkwijk J; Department of Dermatology, Radboud University Medical Center (Radboudumc), 6500HB Nijmegen, the Netherlands., van den Bogaard EH; Department of Dermatology, Radboud University Medical Center (Radboudumc), 6500HB Nijmegen, the Netherlands., Zeeuwen PLJM; Department of Dermatology, Radboud University Medical Center (Radboudumc), 6500HB Nijmegen, the Netherlands.

Publikováno v: IScience [iScience] 2023 Mar 23; Vol. 26 (4), pp. 106483. Date of Electronic Publication: 2023 Mar 23 (Print Publication: 2023).

The mononuclear phagocyte system obscures the accurate diagnosis of infected joint replacements.

Autor: Manasherob, Robert^1,2 (AUTHOR), Warren, Shay I.¹ (AUTHOR), Arora, Prerna¹ (AUTHOR), Heo, Lyong³ (AUTHOR), Haddock, Naomi L.⁴ (AUTHOR), Koliesnik, Ievgen⁵ (AUTHOR), Furukawa, Diasuke⁵ (AUTHOR), Otieno-Ayayo, Z. Ngalo⁶ (AUTHOR), Maloney, William J.¹ (AUTHOR), Lowenberg, David W.¹ (AUTHOR), Goodman, Stuart B.^1,2 (AUTHOR), Amanatullah, Derek F.^1,2 (AUTHOR) dfa@stanford.edu

Publikováno v: Journal of Translational Medicine. 11/19/2024, Vol. 22 Issue 1, p1-19. 19p.

Reverse Signaling by MHC-I Molecules in Immune and Non-Immune Cell Types.

Autor: Muntjewerff EM; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Meesters LD; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands., van den Bogaart G; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Molecular Microbiology and Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, Netherlands., Revelo NH; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.

Publikováno v: Frontiers in immunology [Front Immunol] 2020 Dec 15; Vol. 11, pp. 605958. Date of Electronic Publication: 2020 Dec 15 (Print Publication: 2020).