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Antagonism of HSV-tk transfection and ganciclovir treatment on chemotherapeutic drug sensitivity

Autor: Van Dillen, IJ, Mulder, NH, Meijer, C, Dam, WA, Kamstra, E, De Vries, L, Meersma, GJ, Van Der Zee, AGJ, De Vries, EFJ, Vaalburg, W, Hospers, GAP

Publikováno v: Journal of chemotherapy, 17(3), 289-296

Our study focused on the influence of herpes simplex virus thymidine kinase (HSV-tk) expression and ganciclovir (GCV) treatment on the sensitivity of C6 glioma cells to frequently used chemotherapeutic drugs, i.e. adriamycin (ADR), cisplatin (CDDP),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d169f9b358ec979ce78f53fc88b20f29
https://www.bib.irb.hr/273065

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Telomerase in (pre)neoplastic cervical disease

Autor: Wisman, Gba, Jong, S., Meersma, Gj, Helder, Mn, Hollema, H., Vries, Ege, Nicol Keith, Zee, Agj

Publikováno v: Human Pathology, 31(10), 1304-1312. W B SAUNDERS CO-ELSEVIER INC
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This study was performed to determine upregulation of the human telomerase RNA component (hTR) and mRNA of the catalytic subunit of telomerase (hTERT) in (pre)malignant cervical lesions, to analyze possible intralesional heterogeneity of hTR expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4ee990a9976217a73847b25259487f6a
https://research.rug.nl/en/publications/b19f26fa-8705-4ad0-bd35-146c9252e4b1

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EFFECTS OF AMIODARONE, CYCLOSPORINE-A, AND PSC-833 ON THE CYTOTOXICITY OF MITOXANTRONE, DOXORUBICIN, AND VINCRISTINE IN NON-P-GLYCOPROTEIN HUMAN SMALL-CELL LUNG-CANCER CELL-LINES

Autor: VANDERGRAAF, WTA, DEVRIES, EGE, TIMMERBOSSCHA, H, MEERSMA, GJ, MESANDER, G, VELLENGA, E, MULDER, NH

Publikováno v: Cancer Research, 54(20), 5368-5373. AMER ASSOC CANCER RESEARCH

The multidrug resistance (MDR) modulators amiodarone (AM), cyclosporin A (CsA), and PSC 833 were tested for their potential to modulate cytotoxicity of doxorubicin (DOX), vincristine (VCR), and mitoxantrone (MX) in a sensitive human small cell lung c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::dc9723e2ce0661257048bde4a99a56db
https://research.rug.nl/en/publications/a98f3ffa-4fed-4060-964d-d9f73b479678

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THYMIDYLATE SYNTHASE LEVELS IN TUMOR-BIOPSIES FROM PATIENTS WITH COLORECTAL-CANCER

Autor: MULDER, NH, TIMMERBOSSCHA, H, MEERSMA, GJ, VERSCHUEREN, RCJ

Publikováno v: Anticancer Research, 14(6B), 2677-2680. INT INST ANTICANCER RESEARCH

Catalytic activity and FdUMP binding characteristics of thymidylate synthase (TS) were determined in 22 rumor biopsies of patients to be treated (15) or just treated (7) for colorectal cancer with 5-fluorouracil and leucovorin. In 19 samples both par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::fc076a3aa51094bafca197a7c2ffe34d
https://research.rug.nl/en/publications/0ade4cfd-da49-4dd6-850b-c70ea85aa6ec

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RELATIONSHIP OF CELLULAR GLUTATHIONE TO THE CYTOTOXICITY AND RESISTANCE OF 7 PLATINUM COMPOUNDS

Autor: MEIJER, C, MULDER, NH, TIMMERBOSSCHA, H, SLUITER, WJ, MEERSMA, GJ, DEVRIES, EGE

Publikováno v: Cancer Research, 52(24), 6885-6889. AMER ASSOC CANCER RESEARCH

The role of glutathione (GSH) in the effectiveness of and resistance to 7 platinum compounds [5 Pt(II) and 2 Pt(IV) drugs] was evaluated in a 8.6-fold cisplatin (CDDP)-resistant human small cell lung cancer cell line (GLC4/CDDP), the parent GLC4 line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::5475f22c095e35e10a2de1da80b60489
https://research.rug.nl/en/publications/5fdf59fd-ebbe-48d9-a858-69bc69df27bb

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