Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Meera V Singh"'
Autor:
Md Nasir Uddin, Meera V. Singh, Abrar Faiyaz, Filip Szczepankiewicz, Markus Nilsson, Zachary D. Boodoo, Karli R. Sutton, Madalina E. Tivarus, Jianhui Zhong, Lu Wang, Xing Qiu, Miriam T. Weber, Giovanni Schifitto
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Despite advancements, the prevalence of HIV-associated neurocognitive impairment remains at approximately 40%, attributed to factors like pre-cART (combination antiretroviral therapy) irreversible brain injury. People with HIV (PWH) treated
Externí odkaz:
https://doaj.org/article/934e4fff63dc4a0e9c548f79b9dd29e8
Autor:
Meera V. Singh, Md Nasir Uddin, Mae Covacevich Vidalle, Karli R. Sutton, Zachary D. Boodoo, Angelique N. Peterson, Alicia Tyrell, Madalina E. Tivarus, Henry Z. Wang, Bogachan Sahin, Jianhui Zhong, Miriam T. Weber, Lu Wang, Xing Qiu, Sanjay B. Maggirwar, Giovanni Schifitto
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
BackgroundDespite antiretroviral treatment (cART), aging people living with HIV (PWH) are more susceptible to neurocognitive impairment (NCI) probably due to synergistic/additive contribution of traditional cerebrovascular risk factors. Specifically,
Externí odkaz:
https://doaj.org/article/966b402f354c448595e8a92f0ba94bfe
Autor:
Joseph W Jackson, Meera V Singh, Vir B Singh, Letitia D Jones, Gregory A Davidson, Sara Ture, Craig N Morrell, Giovanni Schifitto, Sanjay B Maggirwar
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157115 (2016)
Platelets play an essential role in hemostasis and wound healing by facilitating thrombus formation at sites of injury. Platelets also mediate inflammation and contain several pro-inflammatory molecules including cytokines and chemokines that mediate
Externí odkaz:
https://doaj.org/article/afc10c01c2484776997688e98f8d9a9d
Autor:
Michelle Kiebala, Meera V Singh, Michael S Piepenbrink, Xing Qiu, James J Kobie, Sanjay B Maggirwar
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130061 (2015)
Recent work has indicated that platelets, which are anucleate blood cells, significantly contribute to inflammatory disorders. Importantly, platelets also likely contribute to various inflammatory secondary disorders that are increasingly associated
Externí odkaz:
https://doaj.org/article/804e25646dab45c68cf5a43554a99490
Autor:
Donna C Davidson, Michael P Hirschman, Anita Sun, Meera V Singh, Karl Kasischke, Sanjay B Maggirwar
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51793 (2012)
Despite the use of anti-retroviral therapies, a majority of HIV-infected individuals still develop HIV-Associated Neurocognitive Disorders (HAND), indicating that host inflammatory mediators, in addition to viral proteins, may be contributing to thes
Externí odkaz:
https://doaj.org/article/35ad28c9e9d043f2bef27609a14daead
Autor:
Mukta G. Palshikar, Rohith Palli, Alicia Tyrell, Sanjay Maggirwar, Giovanni Schifitto, Meera V. Singh, Juilee Thakar
Publikováno v:
npj Systems Biology and Applications, Vol 8, Iss 1, Pp 1-15 (2022)
Abstract Atherosclerosis (AS)-associated cardiovascular disease is an important cause of mortality in an aging population of people living with HIV (PLWH). This elevated risk has been attributed to viral infection, anti-retroviral therapy, chronic in
Externí odkaz:
https://doaj.org/article/50363a7200394f4d9c6f1fb1823f2de9
Autor:
Meera V. Singh, Md Nasir Uddin, Vir B. Singh, Angelique N. Peterson, Kyle D. Murray, Yuchuan Zhuang, Alicia Tyrell, Lu Wang, Madalina E. Tivarus, Jianhui Zhong, Xing Qiu, Giovanni Schifitto
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionDue to advances in combined anti-retroviral treatment (cART), there is an increased burden of age-related cerebrovascular disease (CBVD), in people living with HIV (PWH). The underlying CNS injury can be assessed by measuring cerebral blo
Externí odkaz:
https://doaj.org/article/c240987fa02249898f65da6daee56079
Autor:
Adam Cornwell, Rohith Palli, Meera V. Singh, Lauren Benoodt, Alicia Tyrell, Jun-ichi Abe, Giovanni Schifitto, Sanjay B. Maggirwar, Juilee Thakar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract People living with HIV are at higher risk of atherosclerosis (AS). The pathogenesis of this risk is not fully understood. To assess the regulatory networks involved in AS we sequenced mRNA of the peripheral blood mononuclear cells (PBMCs) an
Externí odkaz:
https://doaj.org/article/50c82d93ef8840fd8ec8d9ebf2e6750a
Autor:
Kyle D. Murray, Md Nasir Uddin, Madalina E. Tivarus, Bogachan Sahin, Henry Z. Wang, Meera V. Singh, Xing Qiu, Lu Wang, Pascal Spincemaille, Yi Wang, Sanjay B. Maggirwar, Jianhui Zhong, Giovanni Schifitto
Publikováno v:
NeuroImage: Clinical, Vol 32, Iss , Pp 102786- (2021)
The aim of this study was to assess, in the context of cerebral small vessel disease (CSVD), whether cardiovascular risk factors and white matter hyperintensities (WMHs) were associated with brain tissue susceptibility as measured by quantitative sus
Externí odkaz:
https://doaj.org/article/79807b13a428435d86b533eb16f676c7
Autor:
Kyle D. Murray, Meera V. Singh, Yuchuan Zhuang, Md Nasir Uddin, Xing Qiu, Miriam T. Weber, Madalina E. Tivarus, Henry Z. Wang, Bogachan Sahin, Jianhui Zhong, Sanjay B. Maggirwar, Giovanni Schifitto
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Rationale: We provide an in-depth description of a comprehensive clinical, immunological, and neuroimaging study that includes a full image processing pipeline. This approach, although implemented in HIV infected individuals, can be used in the gener
Externí odkaz:
https://doaj.org/article/666ea52b702e47338d29c9d84ccf95ce