Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Meera T. Saxena"'
Autor:
Kevin Emmerich, David T. White, Siva P. Kambhampati, Grace L. Casado, Tian-Ming Fu, Zeeshaan Chunawala, Arpan Sahoo, Saumya Nimmagadda, Nimisha Krishnan, Meera T. Saxena, Steven L. Walker, Eric Betzig, Rangaramanujam M. Kannan, Jeff S. Mumm
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Retinal Müller glia function as injury-induced stem-like cells in zebrafish but not mammals. However, insights gleaned from zebrafish have been applied to stimulate nascent regenerative responses in the mammalian retina. For instance, micro
Externí odkaz:
https://doaj.org/article/0098c0b5f2dd4606b3cf44ca818c8a43
Autor:
Arife Unal Eroglu, Timothy S. Mulligan, Liyun Zhang, David T. White, Sumitra Sengupta, Cathy Nie, Noela Y. Lu, Jiang Qian, Lisha Xu, Wuhong Pei, Shawn M. Burgess, Meera T. Saxena, Jeff S. Mumm
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Thousands of genes have been implicated in retinal regeneration, but only a few have been shown to impact the regenerative capacity of Müller glia—an adult retinal stem cell with untapped therapeutic potential. Similarly, among nearly 300 genetic
Externí odkaz:
https://doaj.org/article/26f4e85cc8724161b9abfd475abe72c6
Autor:
Meera T. Saxena, Sara J. Aton, Charles Hildebolt, Julie L. Prior, Ute Abraham, David Piwnica-Worms, Erik D. Herzog
Publikováno v:
Molecular Imaging, Vol 6 (2007)
The use of real-time reporters has accelerated our understanding of gene expression in vivo. This study examined the feasibility of a luciferase-based reporter to image spatiotemporal changes in fetal gene expression in utero. We chose to monitor Per
Externí odkaz:
https://doaj.org/article/4d68cd531c5a4d24a367116b18e312ae
Autor:
Liyun Zhang, Conan Chen, Jie Fu, Brendan Lilley, Cynthia Berlinicke, Baranda Hansen, Ding Ding, Guohua Wang, Tao Wang, Daniel Shou, Ying Ye, Timothy Mulligan, Kevin Emmerich, Meera T Saxena, Kelsi R Hall, Abigail V Sharrock, Carlene Brandon, Hyejin Park, Tae-In Kam, Valina L Dawson, Ted M Dawson, Joong Sup Shim, Justin Hanes, Hongkai Ji, Jun O Liu, Jiang Qian, David F Ackerley, Baerbel Rohrer, Donald J Zack, Jeff S Mumm
Publikováno v:
eLife, Vol 10 (2021)
Retinitis pigmentosa (RP) and associated inherited retinal diseases (IRDs) are caused by rod photoreceptor degeneration, necessitating therapeutics promoting rod photoreceptor survival. To address this, we tested compounds for neuroprotective effects
Externí odkaz:
https://doaj.org/article/ae361e62a3fd4acc8161a7ed3eae9011
Autor:
Michelle H Rich, Abigail V Sharrock, Timothy S Mulligan, Frazer Matthews, Alistair S Brown, Hannah R Lee-Harwood, Elsie M Williams, Janine N Copp, Rory F Little, Jenni JB Francis, Claire N Horvat, Luke J Stevenson, Jeremy G Owen, Meera T Saxena, Jeff S Mumm, David F Ackerley
Publikováno v:
bioRxiv
SummaryFunctional screening of environmental DNA (eDNA) libraries is a potentially powerful approach to discover enzymatic “unknown unknowns”, but is usually heavily biased toward the tiny subset of genes preferentially transcribed and translated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a912240b02a0284245439c0f64bc50dc
https://doi.org/10.1101/2023.03.24.534183
https://doi.org/10.1101/2023.03.24.534183
Autor:
Abigail V. Sharrock, Timothy S. Mulligan, Kelsi R. Hall, Elsie M. Williams, David T. White, Liyun Zhang, Kevin Emmerich, Frazer Matthews, Saumya Nimmagadda, Selena Washington, Katherine D. Le, Danielle Meir-Levi, Olivia L. Cox, Meera T. Saxena, Anne L. Calof, Martha E. Lopez-Burks, Arthur D. Lander, Ding Ding, Hongkai Ji, David F. Ackerley, Jeff S. Mumm
Publikováno v:
Nature methods, vol 19, iss 2
Transgenic expression of bacterial nitroreductase (NTR) enzymes sensitizes eukaryotic cells to prodrugs such as metronidazole (MTZ), enabling selective cell-ablation paradigms that have expanded studies of cell function and regeneration in vertebrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fc22cea9ed01529cf478d87a37f105
https://escholarship.org/uc/item/1fn995n4
https://escholarship.org/uc/item/1fn995n4
Autor:
Ding Ding, Hyejin Park, Jeff S. Mumm, Conan Chen, Tae In Kam, Jiang Qian, Brendan Lilley, Valina L. Dawson, Baranda Hansen, Liyun Zhang, Carlene Brandon, Joong Sup Shim, Baerbel Rohrer, Ying Ye, Kevin Emmerich, Kelsi R. Hall, Jie Fu, Ted M. Dawson, Abigail V. Sharrock, Donald J. Zack, Guohua Wang, Meera T. Saxena, Daniel Shou, Jun O. Liu, David F. Ackerley, Justin Hanes, Tao Wang, Timothy Mulligan, Hongkai Ji, Cynthia Berlinicke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c69cbae701d04e068fd7fc0de67f867
https://doi.org/10.7554/elife.57245.sa2
https://doi.org/10.7554/elife.57245.sa2
Publikováno v:
Adv Drug Deliv Rev
Several key attributes of zebrafish make them an ideal model system for the discovery and development of regeneration promoting therapeutics; most notably their robust capacity for self-repair which extends to the central nervous system. Further, by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d48ddc43d977f6dd75fb4f58c82b29
https://doi.org/10.1016/j.addr.2019.01.011
https://doi.org/10.1016/j.addr.2019.01.011
Autor:
Jeff S. Mumm, Rangaramanujam M. Kannan, Eric Betzig, Tian-Ming Fu, David T. White, Arpan Sahoo, Grace Y. Lee, Kevin Emmerich, Meera T. Saxena, Siva P. Kambhamptati
Müller glia (MG) function as injury-induced retinal stem cells in zebrafish but not mammals. Insights from zebrafish, however, have been used to stimulate limited regenerative responses from mammalian MG. Microglia/macrophages regulate MG stem cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e91d32c9473d726d800e3f54f4c1965
https://doi.org/10.1101/2020.08.05.238352
https://doi.org/10.1101/2020.08.05.238352
Autor:
Kevin B. Emmerich, Steven L. Walker, Guohua Wang, David T. White, Fang Wang, Yong Teng, Anneliese Ceisel, Zeeshaan Chunawala, Gianna Graziano, Saumya Nimmagadda, Meera T. Saxena, Jiang Qian, Jeff S. Mumm
Retinal Müller glia (MG) can act as stem-like cells to generate new neurons in both zebrafish in mice. In zebrafish, retinal regeneration is innate and robust, resulting in the replacement of lost neurons and restoration of visual function. In mice,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fd9ddbbcd6c4976bef764af2591d8fe
https://doi.org/10.1101/2020.08.04.236299
https://doi.org/10.1101/2020.08.04.236299