Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Meera R. Krishnan"'
1
The murine clan VH III related 7183, J606 and S107 and DNA4 families commonly encode for binding to a bacterial B cell superantigen
Autor: Stephen P. Cary, Gregg J. Silverman, Meera R. Krishnan, Tony N. Marion
Publikováno v: Molecular Immunology. 36:769-776
Superantigens, by virtue of their unconventional binding interactions with Ag receptors, can simulate a large subset of mature lymphocytes in the repertoire. Recent studies have documented that in vivo exposure to the model bacterial B cell superanti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7614edef8105021d96805d1f8f3baa7c
https://doi.org/10.1016/s0161-5890(99)00085-1
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2
Monoclonal Anti-DNA Antibodies: Structure, Specificity, and Biology
Autor: Meera R. Krishnan, Nainn-Tsyr Jou, David M. Tillman, Dharmesh D. Desai, Tony N. Marion
Publikováno v: Methods. 11:3-11
Anti-DNA antibodies are a major contributor to the pathogenesis associated with the autoimmune disease systemic lupus erythematosus in mice and human. The accumulation of a large body of structural information on autoimmune anti-DNA antibodies over t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8f0365ca8ffcccd63875068a257a95
https://doi.org/10.1006/meth.1996.0381
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3
Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice
Autor: Tony N. Marion, Meera R. Krishnan, Congmiao Wang
Publikováno v: Kidney international
The strongest serological correlate for lupus nephritis is antibody to double-stranded DNA, although the mechanism by which anti-DNA antibodies initiate lupus nephritis is unresolved. Most recent reports indicate that anti-DNA must bind chromatin in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ab9fbdf74d1bd7176f535c6d1f3928
https://pubmed.ncbi.nlm.nih.gov/22743561
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6
Comparison of the frequencies of arginines in heavy chain CDR3 of antibodies expressed in the primary B-cell repertoires of autoimmune-prone and normal mice
Autor: Meera R. Krishnan, Tony N. Marion
Publikováno v: Scandinavian journal of immunology. 48(3)
Because the pathogenesis of anti-DNA Ab in SLE is correlated to Ab specificity for native DNA (dsDNA), understanding how such specificity is generated is important. The VH structures of most autoimmune anti-DNA antibodies include at least one arginin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106162a4138f9975364bd26c8aaf9a9e
https://pubmed.ncbi.nlm.nih.gov/9743205
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7
Molecular analyses of anti-DNA antibodies induced by polyomavirus BK in BALB/c mice
Autor: Tony N. Marion, Terje Traavik, Ugo Moens, Meera R. Krishnan, K. Hokland, Ole Petter Rekvig, Knut Fredriksen
Publikováno v: Scandinavian journal of immunology. 42(2)
In the present experiments, two groups of BALB/c mice (five individuals in each group) were hyperimmunized through four consecutive immunizations with either BK virus (Group 1) or BK dsDNA complexed with methylated BSA (Group 2). All immune sera take
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0af33f6939226da30365d8fe19d1f3
https://pubmed.ncbi.nlm.nih.gov/7631162
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