Zobrazeno 1 - 10
of 386
pro vyhledávání: '"Meenhard M. Herlyn"'
Autor:
Hyungsoo Kim, Dennie T. Frederick, Mitchell P. Levesque, Zachary A. Cooper, Yongmei Feng, Clemens Krepler, Laurence Brill, Yardena Samuels, Nicholas K. Hayward, Ally Perlina, Adriano Piris, Tongwu Zhang, Ruth Halaban, Meenhard M. Herlyn, Kevin M. Brown, Jennifer A. Wargo, Reinhard Dummer, Keith T. Flaherty, Ze’ev A. Ronai
Publikováno v:
Cell Reports, Vol 11, Iss 9, Pp 1458-1473 (2015)
Despite the remarkable clinical response of melanoma harboring BRAF mutations to BRAF inhibitors (BRAFi), most tumors become resistant. Here, we identified the downregulation of the ubiquitin ligase RNF125 in BRAFi-resistant melanomas and demonstrate
Externí odkaz:
https://doaj.org/article/adafe221293748a28456eeb05b0f1a0b
Autor:
Huang L; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Yang J; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania., Zhu J; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Wang H; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Dong L; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Guo Y; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Chen Y; The Wistar Institute, Philadelphia, Pennsylvania., Zhang F; Department of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Xu DJ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Ou L; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Xu JR; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Guan L; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania., Doan QD; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Fan AY; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Zhong W; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania., Ko J; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Liang C; The Wistar Institute, Philadelphia, Pennsylvania., Herlyn M; The Wistar Institute, Philadelphia, Pennsylvania., Guo W; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania., Xu X; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: xug@pennmedicine.upenn.edu., Liu S; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: shujing@pennmedicine.upenn.edu.
Publikováno v:
The American journal of pathology [Am J Pathol] 2024 Oct 29. Date of Electronic Publication: 2024 Oct 29.
Autor:
Vangala V; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States., Chen YC; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States., Dinavahi SS; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States., Gowda K; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States., Lone NA; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States., Herlyn M; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania 19104, United States., Drabick J; Department of Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States., Helm K; Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States., Zhu J; Department of Pharmaceutical Sciences, Washington State University College of Pharmacy and Pharmaceutical Sciences, Spokane, Washington 99202, United States., Neves RI; Department of Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States., Sharma AK; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States., Berg A; Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States., Archetti M; Department of Biology, Pennsylvania State University, State College, Pennsylvania 16802, United States., Amin S; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States., Schell TD; Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States., Robertson GP; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States.; Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States.; Department of Pathology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States.; Department of Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States.; Foreman Foundation for Melanoma Research, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States.; Melanoma Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States.; Melanoma Therapeutics Program, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States.
Publikováno v:
ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2024 Oct 17; Vol. 7 (11), pp. 3573-3584. Date of Electronic Publication: 2024 Oct 17 (Print Publication: 2024).
Autor:
Wei S, Du K, Lan H, Yang Z, Deng Y, Wei Z, Frederick DT, Lee J, Labrie M, Tian T, Moll T, Chen Y, Sullivan RJ, Mills G, Boland GM, Flaherty KT, Liu L, Herlyn M, Zhang G
Publikováno v:
BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 15. Date of Electronic Publication: 2024 Sep 15.
Autor:
Li J; Genetics and Epigenetics, Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ravindran PT; Cancer Biology Program, Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., O'Farrell A; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA., Busch GT; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA., Boe RH; Genetics and Epigenetics, Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Niu Z; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.; Department of Physics and Astronomy, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA, USA., Woo S; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA., Dunagin MC; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Jain N; Genetics and Epigenetics, Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Goyal Y; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center for Synthetic Biology, Northwestern University, Chicago, IL, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Sarma K; The Wistar Institute, Gene Expression and Regulation program, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Herlyn M; The Wistar Institute, Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Philadelphia, PA, USA., Raj A; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Publikováno v:
BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 25. Date of Electronic Publication: 2024 Jul 25.
Autor:
White BS; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Woo XY; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut.; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Koc S; Velsera, Charlestown, Massachusetts., Sheridan T; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Neuhauser SB; The Jackson Laboratory, Bar Harbor, Maine., Wang S; University of Texas Southwestern Medical Center, Dallas, Texas., Evrard YA; Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland., Chen L; Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland., Foroughi Pour A; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Landua JD; Baylor College of Medicine, Houston, Texas., Mashl RJ; Washington University School of Medicine, St. Louis, Missouri., Davies SR; Washington University School of Medicine, St. Louis, Missouri., Fang B; University of Texas MD Anderson Cancer Center, Houston, Texas., Raso MG; University of Texas MD Anderson Cancer Center, Houston, Texas., Evans KW; University of Texas MD Anderson Cancer Center, Houston, Texas., Bailey MH; Simmons Center for Cancer Research, Brigham Young University, Provo, Utah., Chen Y; The Wistar Institute, Philadelphia, Pennsylvania., Xiao M; The Wistar Institute, Philadelphia, Pennsylvania., Rubinstein JC; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Sanderson BJ; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Lloyd MW; The Jackson Laboratory, Bar Harbor, Maine., Domanskyi S; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Dobrolecki LE; Baylor College of Medicine, Houston, Texas., Fujita M; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah., Fujimoto J; University of Texas MD Anderson Cancer Center, Houston, Texas., Xiao G; University of Texas Southwestern Medical Center, Dallas, Texas., Fields RC; Washington University School of Medicine, St. Louis, Missouri., Mudd JL; Washington University School of Medicine, St. Louis, Missouri., Xu X; The Wistar Institute, Philadelphia, Pennsylvania., Hollingshead MG; National Cancer Institute, Bethesda, Maryland., Jiwani S; Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland., Acevedo S; Velsera, Charlestown, Massachusetts., Davis-Dusenbery BN; Velsera, Charlestown, Massachusetts., Robinson PN; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Moscow JA; National Cancer Institute, Bethesda, Maryland., Doroshow JH; National Cancer Institute, Bethesda, Maryland., Mitsiades N; Baylor College of Medicine, Houston, Texas., Kaochar S; Baylor College of Medicine, Houston, Texas., Pan CX; University of California, Davis, Davis, California., Carvajal-Carmona LG; University of California, Davis, Davis, California., Welm AL; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah., Welm BE; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah., Govindan R; Washington University School of Medicine, St. Louis, Missouri., Li S; Washington University School of Medicine, St. Louis, Missouri., Davies MA; University of Texas MD Anderson Cancer Center, Houston, Texas., Roth JA; University of Texas MD Anderson Cancer Center, Houston, Texas., Meric-Bernstam F; University of Texas MD Anderson Cancer Center, Houston, Texas., Xie Y; University of Texas Southwestern Medical Center, Dallas, Texas., Herlyn M; The Wistar Institute, Philadelphia, Pennsylvania., Ding L; Washington University School of Medicine, St. Louis, Missouri., Lewis MT; Baylor College of Medicine, Houston, Texas., Bult CJ; The Jackson Laboratory, Bar Harbor, Maine., Dean DA 2nd; Velsera, Charlestown, Massachusetts., Chuang JH; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut.
Publikováno v:
Cancer research [Cancer Res] 2024 Jul 02; Vol. 84 (13), pp. 2060-2072.
Autor:
Domanskyi S; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA. Electronic address: sergii.domanskyi@jax.org., Srivastava A; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Kaster J; The Wistar Institute, Philadelphia, PA 19104, USA., Li H; The Wistar Institute, Philadelphia, PA 19104, USA., Herlyn M; The Wistar Institute, Philadelphia, PA 19104, USA., Rubinstein JC; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Hartford HealthCare Cancer Institute at St. Vincent's Medical Center, Bridgeport, CT 06606, USA., Chuang JH; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; UCONN Health Department of Genetics and Genome Sciences, Farmington, CT 06032, USA. Electronic address: jeff.chuang@jax.org.
Publikováno v:
Cell reports methods [Cell Rep Methods] 2024 May 20; Vol. 4 (5), pp. 100759. Date of Electronic Publication: 2024 Apr 15.
Autor:
Rubinstein JC, Domanskyi S, Sheridan TB, Sanderson B, Park S, Kaster J, Li H, Anczukow O, Herlyn M, Chuang JH
Publikováno v:
BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 05. Date of Electronic Publication: 2024 Feb 05.
Autor:
Jagirdar K; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Portuallo ME; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Wei M; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Wilhide M; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Bravo Narula JA; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Robertson BM; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Alicea GM; Department of Chemical and Biomolecular Engineering, The Johns Hopkins Whiting School of Engineering, Baltimore, MD, USA., Aguh C; Department of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Xiao M; The Wistar Institute, Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Philadelphia, PA, USA., Godok T; The Wistar Institute, Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Philadelphia, PA, USA., Fingerman D; The Wistar Institute, Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Philadelphia, PA, USA., Brown GS; The Wistar Institute, Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Philadelphia, PA, USA., Herlyn M; The Wistar Institute, Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Philadelphia, PA, USA., Elad VM; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Guo X; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Toska E; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Zabransky DJ; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Wubbenhorst B; Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Nathanson KL; Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Kwatra S; Department of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Goyal Y; Department of Cell and Developmental Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA., Ji H; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Liu Q; The Wistar Institute, Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Philadelphia, PA, USA., Rebecca VW; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. vrebecc2@jh.edu.; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA. vrebecc2@jh.edu.
Publikováno v:
Oncogene [Oncogene] 2024 Feb; Vol. 43 (6), pp. 395-405. Date of Electronic Publication: 2023 Dec 08.
Autor:
Zhang X; The Wistar Institute, Philadelphia, PA, USA. xzhan325@jh.edu.; Ludwig Institute for Cancer Research, New York, NY, USA. xzhan325@jh.edu.; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. xzhan325@jh.edu., Pant SM; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Ritch CC; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Tang HY; The Wistar Institute, Philadelphia, PA, USA., Shao H; The Wistar Institute, Philadelphia, PA, USA., Dweep H; The Wistar Institute, Philadelphia, PA, USA., Gong YY; The Wistar Institute, Philadelphia, PA, USA.; Ludwig Institute for Cancer Research, New York, NY, USA., Brooks R; The Wistar Institute, Philadelphia, PA, USA.; Ludwig Institute for Cancer Research, New York, NY, USA., Brafford P; The Wistar Institute, Philadelphia, PA, USA.; Ludwig Institute for Cancer Research, New York, NY, USA., Wolpaw AJ; The Wistar Institute, Philadelphia, PA, USA.; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Center for Childhood Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Lee Y; Department of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA., Weeraratna A; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA., Sehgal A; Howard Hughes Medical Institute, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Herlyn M; The Wistar Institute, Philadelphia, PA, USA., Kossenkov A; The Wistar Institute, Philadelphia, PA, USA., Speicher D; The Wistar Institute, Philadelphia, PA, USA., Sorger PK; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Santagata S; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Dang CV; The Wistar Institute, Philadelphia, PA, USA. cvdang@jhmi.edu.; Ludwig Institute for Cancer Research, New York, NY, USA. cvdang@jhmi.edu.; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. cvdang@jhmi.edu.; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. cvdang@jhmi.edu.
Publikováno v:
Nature communications [Nat Commun] 2024 Jan 20; Vol. 15 (1), pp. 633. Date of Electronic Publication: 2024 Jan 20.