Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Meenakshisundaram Thiyagarajan"'
Autor:
Zhong Zhao, Stephen T. Talcott, Nelson Humala, Ilana Seror, Giulio Maria Pasinetti, Susan S. Percival, Lap Ho, Jun Wang, Meenakshisundaram Thiyagarajan, Dara L. Dickstein
Publikováno v:
The FASEB Journal. 20:2313-2320
Recent studies suggest that moderate red wine consumption reduces the incidence of Alzheimer's disease (AD) clinical dementia. Using Tg2576 mice, which model AD-type amyloid beta-protein (Abeta) neuropathology, we tested whether moderate consumption
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b040820f1030b763059ec5b5f1810f09
https://doi.org/10.1096/fj.06-6281com
https://doi.org/10.1096/fj.06-6281com
Autor:
Zhihui Zhong, Rashid Deane, Michael Chopp, John H. Griffin, Dong Liu, Zhang Li, Anthony L. Petraglia, Berislav V. Zlokovic, Sanjay B. Maggirwar, Meenakshisundaram Thiyagarajan, Zhenhua Wu, José A. Fernández, Tong Cheng, Barbra LaRue
Publikováno v:
Nature Medicine. 12:1278-1285
Brain hemorrhage is a serious complication of tissue plasminogen activator (tPA) therapy for ischemic stroke. Here we report that activated protein C (APC), a plasma serine protease with systemic anticoagulant, anti-inflammatory and antiapoptotic act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f540a54c277d4e1e58e36dfde393fe7
https://doi.org/10.1038/nm1498
https://doi.org/10.1038/nm1498
Publikováno v:
British Journal of Pharmacology. 142:899-911
Free radicals have been implicated in cerebral ischemia reperfusion (IR) injury. Massive production of nitric oxide and superoxide results in continuous formation of peroxynitrite even several hours after IR insult. This can produce DNA strand nicks,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::050a6d7868c792050edc31864389d4fb
https://doi.org/10.1038/sj.bjp.0705811
https://doi.org/10.1038/sj.bjp.0705811
Publikováno v:
European Journal of Pharmacology. 453:335-344
The present study was undertaken to investigate the effect of testosterone on the alpha-adrenoceptor-mediated contractile responses in ventral lobe of rat prostate. Contractile responses to various alpha-adrenoceptor agonists (phenylephrine, A61603 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62dacc7b7526a9b8ae24b4e18904bbf4
https://doi.org/10.1016/s0014-2999(02)02452-4
https://doi.org/10.1016/s0014-2999(02)02452-4
Publikováno v:
Circulation Research. 100:155-157
See related article, pages 255–262 Endothelial cell protein C receptor (EPCR) is a type 1 transmembrane glycoprotein with homology to the major histocompatibility complex (MHC)-class 1/CD1 family of molecules.1 EPCR was isolated and cloned as an en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acd0864c28ff7e9cd8bfc528a296c296
https://doi.org/10.1161/01.res.0000258167.48227.84
https://doi.org/10.1161/01.res.0000258167.48227.84
Autor:
Lulu Xie, Hongyi Kang, Qiwu Xu, Michael J. Chen, Yonghong Liao, Meenakshisundaram Thiyagarajan, John O’Donnell, Daniel J. Christensen, Charles Nicholson, Jeffrey J. Iliff, Takahiro Takano, Rashid Deane, Maiken Nedergaard
Publikováno v:
Science (New York, N.Y.). 342(6156)
Taking Out the Trash The purpose of sleep remains mysterious. Using state-of-the-art in vivo two-photon imaging to directly compare two arousal states in the same mouse, Xie et al. (p. 373 ; see the Perspective by Herculano-Houzel ) found that metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a762977a98d8cd5c3601339398a8fd9f
https://pubmed.ncbi.nlm.nih.gov/24435147
https://pubmed.ncbi.nlm.nih.gov/24435147
Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain
Autor:
Benjamin A. Plog, Vinita Rangroo Thrane, Meenakshisundaram Thiyagarajan, Erlend A. Nagelhus, Rashid Deane, Jeffrey J. Iliff, Alexander S. Thrane
Publikováno v:
Scientific Reports
In the brain, a paravascular space exists between vascular cells and astroglial end-foot processes, creating a continuous sheath surrounding blood vessels. Using in vivo two-photon imaging we demonstrate that the paravascular circulation facilitates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe221c67b333ebd453fb1304b510412
http://europepmc.org/articles/PMC3761080
http://europepmc.org/articles/PMC3761080
Autor:
Barbra LaRue, Nathan T. Ross, Rachal Love, Günter Fritz, Nicole Paquette, Richard J. Deane, Benjamin L. Miller, Berislav V. Zlokovic, Alan E. Friedman, Meenakshisundaram Thiyagarajan, Abhay P. Sagare, Robert D. Bell, Rashid Deane, Sheldon Perry, Troy J. Zarcone, Itender Singh
Publikováno v:
The Journal of clinical investigation. 122(4)
In Alzheimer disease (AD), amyloid β peptide (Aβ) accumulates in plaques in the brain. Receptor for advanced glycation end products (RAGE) mediates Aβ-induced perturbations in cerebral vessels, neurons, and microglia in AD. Here, we identified a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d7eaa01e33c5f6683113782da500cb
https://pubmed.ncbi.nlm.nih.gov/22691133
https://pubmed.ncbi.nlm.nih.gov/22691133
Autor:
Corey T. Walker, Anthony L. Petraglia, Andrew H. Marky, Berislav V. Zlokovic, Meenakshisundaram Thiyagarajan
Publikováno v:
Neurosurgery. 66(1)
Objective Activated protein C (APC) is neuroprotective in stroke models and promotes postischemic neovascularization and neurogenesis. We used a controlled cortical impact (CCI) in mice to determine the effects of APC on neuroprotection and angiogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9890082c566a409d71ecab628e52654b
https://pubmed.ncbi.nlm.nih.gov/20023547
https://pubmed.ncbi.nlm.nih.gov/20023547
Autor:
Francis J. Castellino, Anna B. Zlokovic, Berislav V. Zlokovic, Don W. Cleveland, Rashid Deane, Nicole Paquette, Todd Liu, Nienwen Chow, Meenakshisundaram Thiyagarajan, Zhihui Zhong, Hristelina Ilieva, Lee Hallagan, Robert D. Bell, José A. Fernández, Itender Singh, John H. Griffin, Steven M. Lane, Konstantin Stojanovic
Publikováno v:
Journal of Clinical Investigation.
Activated protein C (APC) is a signaling protease with anticoagulant activity. Here, we have used mice expressing a mutation in superoxide dismutase-1 (SOD1) that is linked to amyotrophic lateral sclerosis (ALS) to show that administration of APC or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fb9f7b58624fd54a3af3d439b972bb
https://doi.org/10.1172/jci38476
https://doi.org/10.1172/jci38476