Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Meenakshisundaram B"'
Publikováno v:
Journal of Contemporary Issues in Business and Government. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc93796194be09404e6a696904a127fe
https://doi.org/10.47750/cibg.2021.27.02.409
https://doi.org/10.47750/cibg.2021.27.02.409
Autor:
Meenakshisundaram Balasubramaniam, Jagadeesh Narasimhappagari, Ling Liu, Akshatha Ganne, Srinivas Ayyadevara, Ramani Atluri, Haarika Ayyadevara, Guy Caldwell, Robert J. Shmookler Reis, Steven W. Barger, W. Sue T. Griffin
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Homozygosity for the ε4 allele of APOE increases the odds of developing Alzheimer’s by 12 to 15 times relative to the most common ε3;ε3 genotype, and its association with higher plaque loads comports with evidence that APOEε4 compromis
Externí odkaz:
https://doaj.org/article/878863e67a6c49fcb866ad33ee0326ad
Akademický článek
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Autor:
Meenakshisundaram Balasubramaniam, Akshatha Ganne, Nirjal Mainali, Sonu Pahal, Srinivas Ayyadevara, Robert J. Shmookler Reis
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108745- (2024)
Summary: Alzheimer’s disease (AD) is characterized by peri-neuronal amyloid plaque and intra-neuronal neurofibrillary tangles. These aggregates are identified by the immunodetection of “seed” proteins (Aβ1–42 and hyperphosphorylated tau, res
Externí odkaz:
https://doaj.org/article/0fe45e0d266e41429a8d9af0ceeefb36
Autor:
Akshatha Ganne, Meenakshisundaram Balasubramaniam, Haarika Ayyadevara, Lily Kiaei, Robert J. Shmookler Reis, Kottayil I. Varughese, Mahmoud Kiaei
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) is an inexorably progressive and degenerative disorder of motor neurons with no currently-known cure. Studies to determine the mechanism of neurotoxicity and the impact of ALS-linked mutations (SOD1, FUS,
Externí odkaz:
https://doaj.org/article/b56051c87f51492fbd433b5492d39207
Autor:
Samuel Kakraba, Srinivas Ayyadevara, Nirjal Mainali, Meenakshisundaram Balasubramaniam, Suresh Bowroju, Narsimha Reddy Penthala, Ramani Atluri, Steven W. Barger, Sue T. Griffin, Peter A. Crooks, Robert J. Shmookler Reis
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1498 (2023)
Chronic, low-grade inflammation has been implicated in aging and age-dependent conditions, including Alzheimer’s disease, cardiomyopathy, and cancer. One of the age-associated processes underlying chronic inflammation is protein aggregation, which
Externí odkaz:
https://doaj.org/article/5ef6117e54514590994189c991ada0a2
Autor:
Akshatha Ganne, Meenakshisundaram Balasubramaniam, Srinivas Ayyadevara, Robert J. Shmookler Reis
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Protein structure is determined by the amino acid sequence and a variety of post-translational modifications, and provides the basis for physiological properties. Not all proteins in the proteome attain a stable conformation; roughly one third of hum
Externí odkaz:
https://doaj.org/article/6fb6c170b8b046ffa7899912d868394c
Autor:
Meenakshisundaram Balasubramaniam, Paul A. Parcon, Chhanda Bose, Ling Liu, Richard A. Jones, Martin R. Farlow, Robert E. Mrak, Steven W. Barger, W. Sue T. Griffin
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-17 (2019)
Abstract Background Neuroinflammation, typified by elevated levels of interleukin-1 (IL-1) α and β, and deficits in proteostasis, characterized by accumulation of polyubiquitinated proteins and other aggregates, are associated with neurodegenerativ
Externí odkaz:
https://doaj.org/article/1228e585af3a4aaaad3af58fadaef37e
Autor:
Meenakshisundaram Balasubramaniam, Srinivas Ayyadevara, Akshatha Ganne, Samuel Kakraba, Narsimha Reddy Penthala, Xiuxia Du, Peter A. Crooks, Sue T. Griffin, Robert J. Shmookler Reis
Publikováno v:
iScience, Vol 20, Iss , Pp 248-264 (2019)
Summary: Diagnosis of neurodegenerative diseases hinges on “seed” proteins detected in disease-specific aggregates. These inclusions contain diverse constituents, adhering through aberrant interactions that our prior data indicate are nonrandom.
Externí odkaz:
https://doaj.org/article/9112be5150c14d7ca547e7c09ae2fb86
Autor:
Akshatha Ganne, Meenakshisundaram Balasubramaniam, W. Sue T. Griffin, Robert J. Shmookler Reis, Srinivas Ayyadevara
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1354 (2022)
Glial fibrillary acidic protein (GFAP) is an intermediate filament structural protein involved in cytoskeleton assembly and integrity, expressed in high abundance in activated glial cells. GFAP is neuroprotective, as knockout mice are hypersensitive
Externí odkaz:
https://doaj.org/article/2807e69812ad4fd2bf3c3ab1a912ce5e