Zobrazeno 1 - 10 of 43 pro vyhledávání: '"Meejeon Roh"'
1
Akademický článek
Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation
Autor: Young A. Yoo, Meejeon Roh, Anum F. Naseem, Barbara Lysy, Mohamed M. Desouki, Kenji Unno, Sarki A. Abdulkadir
Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The polycomb repressor protein Bmi1 has a role in self-renewal and tumorigenesis. Here, the authors use lineage tracing to show that Bmi-expressing cells are a distinct population of cells, primarily found in the luminal compartment, which is castrat
Externí odkaz: https://doaj.org/article/723bb9021c454c7c895f31deacc88d0a
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2
Akademický článek
Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancer.
Autor: Jongchan Kim, Isam-Eldin A Eltoum, Meejeon Roh, Jie Wang, Sarki A Abdulkadir
Publikováno v: PLoS Genetics, Vol 5, Iss 7, p e1000542 (2009)
In human somatic tumorigenesis, mutations are thought to arise sporadically in individual cells surrounded by unaffected cells. This contrasts with most current transgenic models where mutations are induced synchronously in entire cell populations. H
Externí odkaz: https://doaj.org/article/797372ff2c0e49d5a566b0cf8a473a05
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3
Akademický článek
A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells.
Autor: Meejeon Roh, Omar E Franco, Simon W Hayward, Riet van der Meer, Sarki A Abdulkadir
Publikováno v: PLoS ONE, Vol 3, Iss 7, p e2572 (2008)
BackgroundPolyploidy is a prominent feature of many human cancers, and it has long been hypothesized that polyploidy may contribute to tumorigenesis by promoting genomic instability. In this study, we investigated whether polyploidy per se induced by
Externí odkaz: https://doaj.org/article/f7c3d302cc6643d9942ab3d9f8a02b8d
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6
Supplemental Figures from SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth
Autor: David Gius, Athanassios Vassilopoulos, Meejeon Roh, Yong-Il Cha, Daniel R. Principe, Haiyan Jiang, Hong-Jun Kang, Xianghui Zou, Yufan Yan, Yueming Zhu, Ha Yong Song, Guoxiang Liu, Ozkan Ozden, Seong-Hoon Park
Supplemental Figure S1. PKM2 is acetylated by PCAF and Tip60. Supplemental Figure S2. SIRT2-knockdown stable MCF7, MDA-MB-231, and HeLa cell lines showed decreased PK activity and increased glycolysis rate. Supplemental Figure S3. LC-Ms/Ms analysis t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c661d2c76b26d28a8d21b3ef60dae0a
https://doi.org/10.1158/0008-5472.22409460.v1
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7
Data from SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth
Autor: David Gius, Athanassios Vassilopoulos, Meejeon Roh, Yong-Il Cha, Daniel R. Principe, Haiyan Jiang, Hong-Jun Kang, Xianghui Zou, Yufan Yan, Yueming Zhu, Ha Yong Song, Guoxiang Liu, Ozkan Ozden, Seong-Hoon Park
Sirtuins participate in sensing nutrient availability and directing metabolic activity to match energy needs with energy production and consumption. However, the pivotal targets for sirtuins in cancer are mainly unknown. In this study, we identify th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d95cab6d29e79ca02dc77324662406
https://doi.org/10.1158/0008-5472.c.6507786.v1
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8
The von Hippel–Lindau Cullin-RING E3 ubiquitin ligase regulates APOBEC3 cytidine deaminases
Autor: Richard T. D'Aquila, Gaël K. Scholtés, Aubrey M. Sawyer, Cristina C. Vaca, Meejeon Roh, Isabelle Clerc, Chisu Song
Publikováno v: Transl Res
The seven members of the A3 family of cytidine deaminases (A3A to A3H) share a conserved catalytic activity that converts cytidines in single-stranded (ss) DNA into uridines, thereby inducing mutations. After their initial identification as cell-intr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e172cc7ab4b6fef9526b2c4ce626f65b
https://doi.org/10.1016/j.trsl.2021.05.002
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