Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Meegan Howlett"'
Autor:
Jacqueline P. Whitehouse, Hilary Hii, Chelsea Mayoh, Marie Wong, Pamela Ajuyah, Paulette Barahona, Louise Cui, Hetal Dholaria, Christine L. White, Molly K. Buntine, Jacob Byrne, Keteryne Rodrigues da Silva, Meegan Howlett, Emily J. Girard, Maria Tsoli, David S. Ziegler, Jason M. Dyke, Sharon Lee, Paul G. Ekert, Mark J. Cowley, Nicholas G. Gottardo, Raelene Endersby
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionEpendymomas (EPN) are the third most common malignant brain cancer in children. Treatment strategies for pediatric EPN have remained unchanged over recent decades, with 10-year survival rates stagnating at just 67% for children aged 0-14
Externí odkaz:
https://doaj.org/article/009c2573d20c46b8a58d763a746781a4
Autor:
Zahra Abbas, Courtney George, Mathew Ancliffe, Meegan Howlett, Anya C. Jones, Mani Kuchibhotla, Robert J. Wechsler-Reya, Nicholas G. Gottardo, Raelene Endersby
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Medulloblastoma is the most common childhood brain cancer. Mainstay treatments of radiation and chemotherapy have not changed in decades and new treatment approaches are crucial for the improvement of clinical outcomes. To date, immunotherapies for m
Externí odkaz:
https://doaj.org/article/444717f125444b249523592585e3f8d3
Autor:
Jessica Buck, Patrick J. C. Dyer, Hilary Hii, Brooke Carline, Mani Kuchibhotla, Jacob Byrne, Meegan Howlett, Jacqueline Whitehouse, Martin A. Ebert, Kerrie L. McDonald, Nicholas G. Gottardo, Raelene Endersby
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Medulloblastoma is the most common malignant childhood brain tumor, and 5-year overall survival rates are as low as 40% depending on molecular subtype, with new therapies critically important. As radiotherapy and chemotherapy act through the inductio
Externí odkaz:
https://doaj.org/article/84c2daf88f7a475d8429aa6028e5b6ae
Autor:
Laurence C. Cheung, Deborah H. Strickland, Meegan Howlett, Jette Ford, Adrian K. Charles, Karen M. Lyons, David R. Brigstock, Roel Goldschmeding, Catherine H. Cole, Warren S. Alexander, Ursula R. Kees
Publikováno v:
Haematologica, Vol 99, Iss 7 (2014)
Hematopoiesis occurs in a complex bone marrow microenvironment in which bone marrow stromal cells provide critical support to the process through direct cell contact and indirectly through the secretion of cytokines and growth factors. We report that
Externí odkaz:
https://doaj.org/article/69074d34281e41a8860bb989935e774c
Autor:
Louise M Judd, Treve R Menheniott, Hui Ling, Cameron B Jackson, Meegan Howlett, Anastasia Kalantzis, Waldemar Priebe, Andrew S Giraud
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e95993 (2014)
Signal Transducer and Activator of Transcription-3 (STAT3) is constitutively activated in many cancers where it promotes growth, inflammation, angiogenesis and inhibits apoptosis. We have shown that STAT3 is constitutively activated in human gastric
Externí odkaz:
https://doaj.org/article/76c9ab94703544b984388bd5f71fe4a5
Autor:
Evangeline R. Jackson, Ryan J. Duchatel, Dilana E. Staudt, Mika L. Persson, Abdul Mannan, Sridevi Yadavilli, Sarah Parackal, Shaye Game, Wai Chin Chong, W. Samantha N. Jayasekara, Marion Le Grand, Padraic S. Kearney, Alicia M. Douglas, Izac J. Findlay, Zacary P. Germon, Holly P. McEwen, Tyrone S. Beitaki, Adjanie Patabendige, David A. Skerrett-Byrne, Brett Nixon, Nathan D. Smith, Bryan Day, Neevika Manoharan, Sumanth Nagabushan, Jordan R. Hansford, Dinisha Govender, Geoff B. McCowage, Ron Firestein, Meegan Howlett, Raelene Endersby, Nicholas G. Gottardo, Frank Alvaro, Sebastian M. Waszak, Martin R. Larsen, Yolanda Colino-Sanguino, Fatima Valdes-Mora, Andria Rakotomalala, Samuel Meignan, Eddy Pasquier, Nicolas André, Esther Hulleman, David D. Eisenstat, Nicholas A. Vitanza, Javad Nazarian, Carl Koschmann, Sabine Mueller, Jason E. Cain, Matthew D. Dun
Publikováno v:
Cancer Research. :OF1-OF17
Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the most lethal of childhood cancers. Palliative radiotherapy is the only established treatment, with median patient survival of 9 to 11 months. ONC201 is a DRD2 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00455c41f4c2b9385b8b6d6009aa81b3
https://doi.org/10.1158/0008-5472.can-23-0186
https://doi.org/10.1158/0008-5472.can-23-0186
Autor:
Matthew D. Dun, Jason E. Cain, Sabine Mueller, Carl Koschmann, Javad Nazarian, Nicholas A. Vitanza, David D. Eisenstat, Esther Hulleman, Nicolas André, Eddy Pasquier, Samuel Meignan, Andria Rakotomalala, Fatima Valdes-Mora, Yolanda Colino-Sanguino, Martin R. Larsen, Sebastian M. Waszak, Frank Alvaro, Nicholas G. Gottardo, Raelene Endersby, Meegan Howlett, Ron Firestein, Geoff B. McCowage, Dinisha Govender, Jordan R. Hansford, Sumanth Nagabushan, Neevika Manoharan, Bryan Day, Nathan D. Smith, Brett Nixon, David A. Skerrett-Byrne, Adjanie Patabendige, Tyrone S. Beitaki, Holly P. McEwen, Zacary P. Germon, Izac J. Findlay, Alicia M. Douglas, Padraic S. Kearney, Marion Le Grand, W. Samantha N. Jayasekara, Wai Chin Chong, Shaye Game, Sarah Parackal, Sridevi Yadavilli, Abdul Mannan, Mika L. Persson, Dilana E. Staudt, Ryan J. Duchatel, Evangeline R. Jackson
All Supplementary Figures and their captions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9e68dc3c6f26e99f51f1fbaa7e5b3a
https://doi.org/10.1158/0008-5472.22892044
https://doi.org/10.1158/0008-5472.22892044
Autor:
Matthew D. Dun, Jason E. Cain, Sabine Mueller, Carl Koschmann, Javad Nazarian, Nicholas A. Vitanza, David D. Eisenstat, Esther Hulleman, Nicolas André, Eddy Pasquier, Samuel Meignan, Andria Rakotomalala, Fatima Valdes-Mora, Yolanda Colino-Sanguino, Martin R. Larsen, Sebastian M. Waszak, Frank Alvaro, Nicholas G. Gottardo, Raelene Endersby, Meegan Howlett, Ron Firestein, Geoff B. McCowage, Dinisha Govender, Jordan R. Hansford, Sumanth Nagabushan, Neevika Manoharan, Bryan Day, Nathan D. Smith, Brett Nixon, David A. Skerrett-Byrne, Adjanie Patabendige, Tyrone S. Beitaki, Holly P. McEwen, Zacary P. Germon, Izac J. Findlay, Alicia M. Douglas, Padraic S. Kearney, Marion Le Grand, W. Samantha N. Jayasekara, Wai Chin Chong, Shaye Game, Sarah Parackal, Sridevi Yadavilli, Abdul Mannan, Mika L. Persson, Dilana E. Staudt, Ryan J. Duchatel, Evangeline R. Jackson
Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the most lethal of childhood cancers. Palliative radiotherapy is the only established treatment, with median patient survival of 9 to 11 months. ONC201 is a DRD2 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2ec734b3b0e0b8ca6a532d4cfa2040
https://doi.org/10.1158/0008-5472.c.6651055.v1
https://doi.org/10.1158/0008-5472.c.6651055.v1
Autor:
Jacqueline Whitehouse, Meegan Howlett, Jessica Buck, Kale Somers, Jessica Lawler, Hilary Hii, Brooke Carline, Mani Kuchibhotla, Bhedita Sewoo, Tim Rosenow, Kirk Feindel, Martin Ebert, Andrew Mehnert, Nicholas Gottardo, Raelene Endersby
Publikováno v:
Neuro-Oncology. 24:i177-i178
Pediatric brain cancer patients treated with fractionated radiotherapy commonly develop long-term late side-effects including cognitive deficits. Many preclinical models of late effects have been developed that use a single, high dose of radiotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::852bc7bda20e2aa76f7bb2fd1016ea20
https://doi.org/10.1093/neuonc/noac079.661
https://doi.org/10.1093/neuonc/noac079.661
Autor:
Zahra Abbas, Jessica Buck, Mathew Ancliffe, Clara Andradas Arias, Meegan Howlett, Hilary Hii, Terrance Johns, Siddhartha Mitra, Nicholas Gottardo, Raelene Endersby
Publikováno v:
Neuro-Oncology. 24:i172-i173
Medulloblastoma is the most common paediatric brain cancer. Standard treatment approaches, including craniospinal irradiation (CSI), can result in severe lifelong side effects and have not changed for decades resulting in a stagnation of survival out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14c2eccee208ea29c066affa178f57b8
https://doi.org/10.1093/neuonc/noac079.641
https://doi.org/10.1093/neuonc/noac079.641